Electrocortical activity in freely walking rats varies with environmental conditions

Li, Bo; Liu, Sican; Hu, Dingyin; Li, Guanghui; Tang, Rongyu; Song, Da; Lang, Yiran; He, Jiping

doi:10.1016/j.brainres.2020.147188

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…One self-developed 32-channel EEG electrode was used to acquire EEG signals. Previous studies have reported on the effectiveness and safety of electrode use [ 47 , 51 ]. The size of the electrode is shown in Figure 3 A.…”

Section: Methodsmentioning

confidence: 99%

Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory

Zhang

Liu

et al. 2021

Micromachines

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Epilepsy is common brain dysfunction, where abnormal synchronized activities can be observed across multiple brain regions. Low-frequency focused pulsed ultrasound has been proven to modulate the epileptic brain network. In this study, we used two modes of low-intensity focused ultrasound (pulsed-wave and continuous-wave) to sonicate the brains of KA-induced epileptic rats, analyzed the EEG functional brain connections to explore their respective effect on the epileptic brain network, and discuss the mechanism of ultrasound neuromodulation. By comparing the brain network characteristics before and after sonication, we found that two modes of ultrasound both significantly affected the functional brain network, especially in the low-frequency band below 12 Hz. After two modes of sonication, the power spectral density of the EEG signals and the connection strength of the brain network were significantly reduced, but there was no significant difference between the two modes. Our results indicated that the ultrasound neuromodulation could effectively regulate the epileptic brain connections. The ultrasound-mediated attenuation of epilepsy was independent of modes of ultrasound.

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Section: Methodsmentioning

confidence: 99%

Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory

Zhang

Liu

et al. 2021

Micromachines

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“…This may be because the animals needed to walk with their hind limbs on the treadmill and maintain a rear position of the body, so the multimodal nerve signals showed a temporal repeated pattern [ 59 ]. On the wheel, the rats walked with all four limbs, so the pressure on each limb was relatively dispersed, which invokes less strength in the downhill phase [ 30 ], so the fluctuation of signals was relatively weak. In the open field task, the neural activities of the motor cortex and spinal cord ceased while the trunk movements stopped, but the sciatic nerve activities and EMG signals remained active.…”

Section: Discussionmentioning

confidence: 99%

“…Cortical neuron recording has been extensively applied in neuroscience research [ 19 , 20 ]. Various electrodes have also been developed, such as the most commonly used microwire electrode [ 21 ], silicon probe [ 22 ], floating or adjustable microelectrode array [ 23 , 24 , 25 ], electrode combined with optogenetic fibers [ 26 , 27 , 28 , 29 ], and EEG electrode [ 30 , 31 ]. Among them, the electrode array with an adjustable shaft can continuously adjust the depth of the tip of the electrode and obtain a good-quality signal for a long time.…”

Section: Introductionmentioning

confidence: 99%

Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats

et al. 2021

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Neural interfaces typically focus on one or two sites in the motoneuron system simultaneously due to the limitation of the recording technique, which restricts the scope of observation and discovery of this system. Herein, we built a system with various electrodes capable of recording a large spectrum of electrophysiological signals from the cortex, spinal cord, peripheral nerves, and muscles of freely moving animals. The system integrates adjustable microarrays, floating microarrays, and microwires to a commercial connector and cuff electrode on a wireless transmitter. To illustrate the versatility of the system, we investigated its performance for the behavior of rodents during tethered treadmill walking, untethered wheel running, and open field exploration. The results indicate that the system is stable and applicable for multiple behavior conditions and can provide data to support previously inaccessible research of neural injury, rehabilitation, brain-inspired computing, and fundamental neuroscience.

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“…It is likely that the unexpected terrain change increased the difficulty of movement in rats, which made the sensory cortex more involved in the processing of sensory information. Other studies have also reported that as the difficulty of the task increases, there is a significant desynchronization of the power in the γ band [ 18 , 73 ], and the involvement of the cortex also increases [ 74 ]. However, under the FU condition, the γ band of the right S1 showed a significant ERS, which was opposite to those of the other conditions ( Figure 4 H and Figure 5 D).…”

Section: Discussionmentioning

confidence: 99%

Unexpected Terrain Induced Changes in Cortical Activity in Bipedal-Walking Rats

Liu

Zhang

et al. 2021

Biology

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Humans and other animals can quickly respond to unexpected terrains during walking, but little is known about the cortical dynamics in this process. To study the impact of unexpected terrains on brain activity, we allowed rats with blocked vision to walk on a treadmill in a bipedal posture and then walk on an uneven area at a random position on the treadmill belt. Whole brain EEG signals and hind limb kinematics of bipedal-walking rats were recorded. After encountering unexpected terrain, the θ band power of the bilateral M1, the γ band power of the left S1, and the θ to γ band power of the RSP significantly decreased compared with normal walking. Furthermore, when the rats left uneven terrain, the β band power of the bilateral M1 and the α band power of the right M1 decreased, while the γ band power of the left M1 significantly increased compared with normal walking. Compared with the flat terrain, the θ to low β (3–20 Hz) band power of the bilateral S1 increased after the rats contacted the uneven terrain and then decreased in the single- or double- support phase. These results support the hypothesis that unexpected terrains induced changes in cortical activity.

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Electrocortical activity in freely walking rats varies with environmental conditions

Cited by 6 publications

References 37 publications

Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory

Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory

Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats

Unexpected Terrain Induced Changes in Cortical Activity in Bipedal-Walking Rats

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