Electrodialytic Extraction in Drug Analysis. III. Some Practical Applications of the Electrodialytic Extraction Method

Tsunakawa, Nobutaka

doi:10.1248/cpb.19.2585

Cited by 6 publications

(5 citation statements)

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“…Tsunakawa performed a comprehensive study on electrodialytic behavior of a range of pharmaceutical compounds [42][43][44] in a flow-through ED cell with subsequent spectrophotometric determination of dialysates. Sample (1 mL) in sample compartment was stagnant while the extraction solution was propelled through the ED cell at given flow rates on application of a d.c. voltage.…”

Section: Edmentioning

confidence: 99%

“…Generally, recoveries close to 100% were achieved for optimized experimental conditions and for majority of the compounds tested; note however that some analytes were not amenable to ED and significantly lower recovery values were obtained for example for caffeine [43]. The method was also applied to analyses of real samples, such as milk powder and pharmaceutical preparations; the experimental arrangement was, however, not fully compatible with trace analysis demands for up-to-date analytical instrumentation [44]. ED in analytical scale was later also used for preconcentration and separation of metal ions prior to their spectrophotometric determination [45] and for separation of alanine and aspartic acid [46].…”

Section: Edmentioning

confidence: 99%

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Electric field‐enhanced transport across phase boundaries and membranes and its potential use in sample pretreatment for bioanalysis

2010

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Separation techniques, such as electrodialysis, electroextraction, electro-membrane extraction and extraction across phase interfaces, are reviewed and discussed as methods for sample cleanup and preconcentration. This survey clearly shows that electromigration of ionic species across phase interfaces, especially across supported liquid membranes, may be very selective and is strongly dependent on the chemical composition of these interfaces. Thus, electric field-enhanced transport across chemically tailored liquid membranes may open new perspectives in preparative analytical chemistry. This review offers comprehensive survey of related literature and discussion of the topic, which may stimulate interest of experts and practitioners in bioanalysis.

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Section: Edmentioning

confidence: 99%

Section: Edmentioning

confidence: 99%

Electric field‐enhanced transport across phase boundaries and membranes and its potential use in sample pretreatment for bioanalysis

2010

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“…Surprisingly, there has not been a continuous and particular interest in using ED in analytical applications and such applications are rare. One of the first applications was described in a series of papers by Tsunakawa 7–9, in which various pharmaceutical compounds from model tablet formulations were electrodialyzed through a cellulose‐type membrane. Although these papers provide a wide range of data on various compounds of pharmaceutical interest, only one compound at a time was analyzed using a simple flow injection analysis (FIA) system.…”

Section: Introductionmentioning

confidence: 99%

Analysis of inorganic cations in biological samples by the combination of micro‐electrodialysis and capillary electrophoresis with capacitively coupled contactless conductivity detection

Doan

Kubáň

et al. 2011

Electrophoresis

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Micro-electrodialysis (μED) and CE were combined for rapid pretreatment and subsequent determination of inorganic cations in biological samples. Combination of μED with CE greatly improved the analytical performance of the latter as the adsorption of high molecular weight compounds present in real samples on the inner capillary wall was eliminated. Fifty microliter of 80-fold diluted human body fluids such as plasma, serum and whole blood was used in the donor compartment of the μED system requiring less than 1 μL of the original body fluid per analysis. Inorganic cations that migrated through a cellulose acetate dialysis membrane with molecular weight cut-off value of 500 Da were collected in the acceptor solution and were then analyzed using CE-C⁴D. Baseline separation of inorganic cations was achieved in a BGE solution consisting of 12.5 mM maleic acid, 15 mM L-arginine and 3 mM 18-crown-6 at pH 5.5. Repeatability of the CE-C⁴D method was better than 0.5% and 2.5% for migration times and peak areas, respectively; limits of detection of all inorganic cations in the presence of 2 mM excess of Na(+) were around 1 μM and calibration curves were linear with correlation coefficients better than 0.998. Repeatability of the sample pretreatment procedure was calculated for six independent electrodialysis runs of artificial and real samples and was better than 11.8%. Recovery values between 96.3 and 110% were achieved for optimized electrodialysis conditions of standard solutions and real samples; lifetime of the dialysis membranes for pretreatment of real samples was estimated to 100 runs.

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“…Nowadays important industrial applications are in the desalination of brackish water, brine production and in the food industry. Electrodialysis has only rarely been used for analytical-scale work [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Several separation principles have beeO utilised in on-line sample treatment techniques, such as solid-phase extraction [7], zone electrophoresis [8][9][10][11] and dialysis [12][13][14][15][16][17]. First studies on electrodialysis as an extraction technique showed adequate separation of drugs from cellulose mixtures and solubilised milk powder [3][4][5]. Apart from sample clean-up, electrodial" ysis can also provide enrichment of ions from a flowing (sample) donor solution into a stagnant acceptor solution.…”

Section: Introductionmentioning

confidence: 99%

Theoretical models for electrodialytic sample treatment in trace analysis by liquid chromatography

et al. 1994

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Theoretical models for electrodialytic sample treatment in trace analysis by liquid chromatography. Debets, A.J.J.; van Wier, P.; Brinkman, U.A.Th.; Kok, W.T. Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Key WordsColumn liquid chromatography Electrodialytic sample treatment Computer models Analyte enrichment SummaryBasic considerations for analyte enrichment and recovery obtainable by electrodialysis as a sample treatment method are given. Equations are derived which describe the dependence of the concentration profiles of ionic compounds on the electric field strength in a set-up with stagnant donor and acceptor solutions. It is shown that analyte recovery increases when less ion-selective membranes are used in the electrodialysis cell. Computer models are used to estimate the analyte enrichment for a flowing donor (sample) and a stagnant acceptor phase. About 10-fold enrichment can be obtained in an electrodialytic sample treatment system within 20 min under maximum current conditions. A compromise has to be found between analyte recovery and the donor (sample) flow rate.

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Electrodialytic Extraction in Drug Analysis. III. Some Practical Applications of the Electrodialytic Extraction Method

Cited by 6 publications

References 0 publications

Electric field‐enhanced transport across phase boundaries and membranes and its potential use in sample pretreatment for bioanalysis

Electric field‐enhanced transport across phase boundaries and membranes and its potential use in sample pretreatment for bioanalysis

Analysis of inorganic cations in biological samples by the combination of micro‐electrodialysis and capillary electrophoresis with capacitively coupled contactless conductivity detection

Theoretical models for electrodialytic sample treatment in trace analysis by liquid chromatography

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