Electroencephalographic Sleep in Mania

Hudson, James I.; Lipinski, Joseph F.; Frankenburg, Frances R.; Grochocinski, Victoria J.; Kupfer, David J.

doi:10.1001/archpsyc.1988.01800270085010

Cited by 109 publications

(45 citation statements)

References 32 publications

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“…[35][36][37][38][39][40][41] The reports of persisting sleep EEG changes in remitted patients point to a comorbidity of depression or anamnesis of depression as an explanation for shortened REM latency in these disorders. 24,25 The latter view is supported by two studies.…”

Section: Controlsmentioning

confidence: 99%

Sleep electroencephalography as a biomarker in depression

Steiger¹,

Pawlowski²,

Kimura³

2015

CPT

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Abstract:The sleep electroencephalogram (EEG) provides biomarkers of depression, which may help with diagnosis, prediction of therapy response, and prognosis in the treatment of depression. In patients with depression, characteristic sleep EEG changes include impaired sleep continuity, disinhibition of rapid-eye-movement (REM) sleep, and impaired non-REM sleep. Most antidepressants suppress REM sleep in depressed patients, healthy volunteers, and in animal models. REM suppression appears to be an important, but not an absolute requirement, for antidepressive effects of a substance. Enhanced REM density, a measure for frequency of REM, characterizes high-risk probands for affective disorders. REM-sleep changes were also found in animal models of depression. Sleep-EEG variables were shown to predict the response to treatment with antidepressants. Furthermore, certain clusters of sleep EEG variables predicted the course of the disorder for several years. Some of the predicted sleep EEG markers appear to be related to hypothalamic-pituitary-adrenal system activity.

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Section: Controlsmentioning

confidence: 99%

Sleep electroencephalography as a biomarker in depression

Steiger¹,

Pawlowski²,

Kimura³

2015

CPT

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“…An SWS deficit has been described in mania, although this finding has not been confirmed in studies with a greater number of patients (6,10). Lithium carbonate did not affect delta sleep in manic or normal individuals (9), but was reported to be increased in depressed patients after lithium treatment (31).…”

Section: Discussionmentioning

confidence: 95%

“…www.bjournal.com.br shortened rapid eye movement (REM) latency, and increased REM density compared to their pre-morbid state (4)(5)(6)(7)(8) and compared to controls (9,10).…”

Section: Introductionmentioning

confidence: 99%

“…There is also some evidence that olanzapine is effective in some bipolar patients who are refractory to other conventional treatments (15). The favorable tolerability profile of olanzapine might be due to its affinity at dopaminergic D 1 -D 4 , serotonergic (5-HT 2,3,6 ), muscarinic (subtypes [1][2][3][4][5], adrenergic (α-1), and histaminergic (H 1 ) binding sites (11). The main PSG finding for olanzapine tested on healthy subjects is an increase of slow-wave sleep (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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A double-blind comparison of the effect of the antipsychotics haloperidol and olanzapine on sleep in mania

Moreno

Hanna²,

Tavares³

et al. 2007

Braz J Med Biol Res

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The effects of haloperidol and olanzapine on polysomnographic measures made in bipolar patients during manic episodes were compared. Twelve DSM-IV mania patients were randomly assigned to receive either haloperidol (mean ± SD final dosage: 5.8 ± 3.8 mg) or olanzapine (mean ± SD final dosage: 13.6 ± 6.9 mg) in a 6-week, double-blind, randomized, controlled clinical trial. One-night polysomnographic evaluation was performed before and after the haloperidol or olanzapine treatment. Psychopathology and illness severity were rated respectively with the Young Mania Rating Scale (YMRS) and the Clinical Global Impressions -Bipolar version (CGI-BP). There was a significant improvement in the YMRS and CGI-BP scores at the end of the study for both groups. Mixed ANOVA used to compare the polysomnographic measures of both drugs demonstrated significant improvement in sleep measures with olanzapine. In the olanzapine group, statistically significant time-drug interaction effects on sleep continuity measures were observed: sleep efficiency (mean ± SEM pre-treatment value: 6.7 ± 20.3%; after-treatment: 85.7 ± 10.9%), total wake time (pre-treatment: 140.0 ± 92.5 min; aftertreatment: 55.2 ± 44.2 min), and wake time after sleep onset (pretreatment: 109.7 ± 70.8 min; after-treatment: 32.2 ± 20.7 min). Conversely, improvement of polysomnographic measures was not observed for the haloperidol group (P > 0.05). These results suggest that olanzapine is more effective than haloperidol in terms of sleeppromoting effects, although olanzapine is comparatively as effective as haloperidol in treating mania. Polysomnography records should provide useful information on how manic states can be affected by psychopharmacological agents.

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“…In another study drawing attention to the relation between negative family history and abnormal EEG (electroencephalography), small sharp spikes were demonstrated in nearly half of these cases (Kano, Nakamura, & Matsuoka, 1992). In some studies, relation was found between being refractory to treatment and some disorders in the form of sleep spindles detected in the awake EEG of some patients (Hudson, Lipinski, & Frankenburg, 1988). In another study, in BD, temporal epileptic discharges and absence episodes correlating with episodic psychiatric symptoms in BD were found (Field & Diego, 2008).…”

Section: Introductionmentioning

confidence: 98%

EEG (Electroencephalography) Abnormality in First Episode Mania: Is It Trait or State?

Kesebir¹,

Güven²,

Yaylacı³

et al. 2013

JPR

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The aim of this study is to investigate the frequency of abnormal EEG (electroencephalography) findings in first episode mania and to determine whether EEG abnormality improves at the subsequent remission period. The secondary, to compare cases with or without abnormal EEG findings with regard to clinical characteristics of BD (bipolar disorder). In the present study, 86 consecutive first attack mania cases between the ages of 18-65 diagnosed as BD, manic episode according to DSM-IV who referred to our outpatient clinic or emergency service whose informed consent form was signed by first degree relatives were evaluated. Inclusion criteria were not having previous depressive episode, absence of any neurologic disorder, especially epilepsy, absence of history head trauma, and/or loss of consciousness and were not using any drugs which can influence electroenecepholafraphic activity before EEG (antiepileptic, anxiolytic, antidepressant, and antipsychotics). Diagnostic interviews were made with SCID-I (DSM-IV Structured Clinical Interview) and information on disease was recorded with SKIP-TURK (Mood Disorder Diagnosis and Follow-up Form). EEG recordings were made withdigital EEG device in 16 channels. EEG abnormality is more frequent in mania than remission period (p = 0.022) and occurs at the rate of 28.7%. All cases with continuing abnormal EEG findings in remission period are women.In cases with continuing EEG abnormality, the age of menarche is smaller (p = 0.032) but family history is less frequent (p = 0.008). Childhood trauma and history of suicide attempt is more frequent in cases with abnormal EEG in remission period as well (p < 0.001 and 0.005). Of the cases, whose abnormal EEG improved in remission period, 83.3% were treated with anticonvulsants. In some bipolar cases, abnormal EEG is present from the onset of disease and it is associated with some clinical characteristics. Abnormal EEG returns to normal in half of the cases in remission period.

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Electroencephalographic Sleep in Mania

Cited by 109 publications

References 32 publications

Sleep electroencephalography as a biomarker in depression

Sleep electroencephalography as a biomarker in depression

A double-blind comparison of the effect of the antipsychotics haloperidol and olanzapine on sleep in mania

EEG (Electroencephalography) Abnormality in First Episode Mania: Is It Trait or State?

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