Electrokinetic behavior of two touching inhomogeneous biological cells and colloidal particles: Effects of multipolar interactions

Huang, Jue; Karttunen, Mikko; Yu, K. W.; Dong, Lei; Gu, G. Q.

doi:10.1103/physreve.69.051402

Cited by 27 publications

(30 citation statements)

References 36 publications

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“…The DEP force between two lossy particles in a lossy medium, incorporating multipoles polarized by an external field, has been treated by Sancho et al 54 A multiple image approximation has been employed to study the polarization spectra of a pair of touching cells and colloidal particles. 55 These studies were restricted to plain spherical particles, aligned with the direction of the electric field. The practical calculation of the interaction requires truncation of expansions at some finite number of terms and is affected by convergence problems when particles have high permittivity or they are closely spaced.…”

Section: Presence Of Perturbing Boundaries or Particlesmentioning

confidence: 99%

Review Article—Dielectrophoresis: Status of the theory, technology, and applications

2010

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A review is presented of the present status of the theory, the developed technology and the current applications of dielectrophoresis ͑DEP͒. Over the past 10 years around 2000 publications have addressed these three aspects, and current trends suggest that the theory and technology have matured sufficiently for most effort to now be directed towards applying DEP to unmet needs in such areas as biosensors, cell therapeutics, drug discovery, medical diagnostics, microfluidics, nanoassembly, and particle filtration. The dipole approximation to describe the DEP force acting on a particle subjected to a nonuniform electric field has evolved to include multipole contributions, the perturbing effects arising from interactions with other cells and boundary surfaces, and the influence of electrical double-layer polarizations that must be considered for nanoparticles. Theoretical modelling of the electric field gradients generated by different electrode designs has also reached an advanced state. Advances in the technology include the development of sophisticated electrode designs, along with the introduction of new materials ͑e.g., silicone polymers, dry film resist͒ and methods for fabricating the electrodes and microfluidics of DEP devices ͑photo and electron beam lithography, laser ablation, thin film techniques, CMOS technology͒. Around three-quarters of the 300 or so scientific publications now being published each year on DEP are directed towards practical applications, and this is matched with an increasing number of patent applications. A summary of the US patents granted since January 2005 is given, along with an outline of the small number of perceived industrial applications ͑e.g., mineral separation, micropolishing, manipulation and dispensing of fluid droplets, manipulation and assembly of micro components͒. The technology has also advanced sufficiently for DEP to be used as a tool to manipulate nanoparticles ͑e.g., carbon nanotubes, nano wires, gold and metal oxide nanoparticles͒ for the fabrication of devices and sensors. Most efforts are now being directed towards biomedical applications, such as the spatial manipulation and selective separation/enrichment of target cells or bacteria, high-throughput molecular screening, biosensors, immunoassays, and the artificial engineering of three-dimensional cell constructs. DEP is able to manipulate and sort cells without the need for biochemical labels or other bioengineered tags, and without contact to any surfaces. This opens up potentially important applications of DEP as a tool to address an unmet need in stem cell research and therapy.

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Section: Presence Of Perturbing Boundaries or Particlesmentioning

confidence: 99%

Review Article—Dielectrophoresis: Status of the theory, technology, and applications

2010

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“…The similar approach may also be extended to anisotropic medium with different radial and tangential conductivities [22]. Similar work can be extended to ac electrokinetics of graded cells [23]. We can also study the interparticle force between graded particles [24].…”

Section: Discussionmentioning

confidence: 99%

Effective conductivity of composites of graded spherical particles

2005

Physics Letters A

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We have employed the first-principles approach to compute the effective response of composites of graded spherical particles of arbitrary conductivity profiles. We solve the boundary-value problem for the polarizability of the graded particles and obtain the dipole moment as well as the multipole moments. We provide a rigorous proof of an ad hoc approximate method based on the differential effective multipole moment approximation (DEMMA) in which the differential effective dipole approximation (DEDA) is a special case.The method will be applied to an exactly solvable graded profile. We show that DEDA and DEMMA are indeed exact for graded spherical particles. PACS Number(s): 77.84.Lf, 42.79.Ry, 41.20.Cv

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“…To this end, reasonable criteria of the trapping conditions for isolated particles with idealized geometries can be formulated by using simplified hydrodynamics [14,16]. However, in the event of particle aggregation the situation becomes much more complicated [21,22].…”

Section: Introductionmentioning

confidence: 99%

Dielectrophoresis of nanocolloids: A molecular dynamics study

et al. 2005

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Abstract. Dielectrophoresis (DEP), the motion of polarizable particles in non-uniform electric fields, has become an important tool for the transport, separation, and characterization of microparticles in biomedical and nanoelectronics research. In this article we present, to our knowledge, the first molecular dynamics simulations of DEP of nanometersized colloidal particles. We introduce a simplified model for polarizable nanoparticles, consisting of a large charged macroion and oppositely charged microions, in an explicit solvent. The model is then used to study DEP motion of the particle at different combinations of temperature and electric field strength. In accord with linear response theory, the particle drift velocities are shown to be proportional to the DEP force. Analysis of the colloid DEP mobility shows a clear time dependence, demonstrating the variation of friction under non-equilibrium. The time dependence of the mobility further results in an apparent weak variation of the DEP displacements with temperature.

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Electrokinetic behavior of two touching inhomogeneous biological cells and colloidal particles: Effects of multipolar interactions

Cited by 27 publications

References 36 publications

Review Article—Dielectrophoresis: Status of the theory, technology, and applications

Review Article—Dielectrophoresis: Status of the theory, technology, and applications

Effective conductivity of composites of graded spherical particles

Dielectrophoresis of nanocolloids: A molecular dynamics study

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