Electromagnetic Field Effect or Simply Stress? Effects of UMTS Exposure on Hippocampal Longterm Plasticity in the Context of Procedure Related Hormone Release

Prochnow, Nora; Gebing, Tina; Ladage, Kerstin; Krause-Finkeldey, Dorothee; Ouardi, A. El; Bitz, Andreas K.; Streckert, Joachim; Hansen, V.; Dermietzel, Rolf

doi:10.1371/journal.pone.0019437

Cited by 26 publications

(15 citation statements)

References 73 publications

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“…The increased CORT levels found in GSM-exposed 6 week-old rats were not in accordance with the literature showing the absence of a CORT levels modification relative to EMF exposure in in vivo studies in adult Fischer 344 and Wistar rats (Prochnow et al, 2011;Stagg et al, 2001). However, previous studies showed middle-aged related differences in plasmatic CORT or corticotropin-releasing factor responses to different types of stress when compared to young animals (Nolan et al, 1991;Pisarska et al, 2000).…”

Section: Gsm Exposure Stress and Emotional Memorycontrasting

confidence: 76%

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Bouji¹,

Lecomte²,

Hode³

et al. 2012

Experimental Gerontology

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. Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats. Experimental Gerontology, Elsevier, 2012, 47 (6) ABSTRACTThe widespread use of mobile phones raises the question of the effects of electromagnetic fields (EMF, 900 MHz) on the brain. Previous studies reported increased levels of the glial fibrillary acidic protein (GFAP) in the rat's brain after a single exposure to 900 MHz global system for mobile (GSM) signal, suggesting a potential inflammatory process. While this result was obtained in adult rats, no data is currently available in older animals. Since the transition from middle-age to senescence is highly dependent on environment and lifestyle, we studied the reactivity of middle-aged brains to EMF exposure. We assessed the effects of a single 15 min GSM exposure (900MHz; specific absorption rate (SAR) = 6 W/kg) on GFAP expression in young adults (6 week-old) and middle-aged rats (12 month-old). Brain interleukin (IL)-1β and IL-6, plasmatic levels of corticosterone (CORT), and emotional memory were also assessed.Our data indicated that, in contrast to previously published work, acute GSM exposure did not induce astrocytes activation. Our results showed an IL-1β increase in the olfactory bulb and enhanced contextual emotional memory in GSM-exposed middle-aged rats, and increased plasmatic levels of CORT in GSM-exposed young adults. Altogether, our data showed an age dependency of reactivity to GSM exposure in neuroimmunity, stress and behavioral parameters. Reproducing these effects and studying their mechanisms may allow a better understanding of mobile phone EMF effects on neurobiological parameters.

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Section: Gsm Exposure Stress and Emotional Memorycontrasting

confidence: 76%

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Bouji¹,

Lecomte²,

Hode³

et al. 2012

Experimental Gerontology

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“…and summarized in table S1. LTP responses were analyzed as described [26]. All values are expressed as mean ± standard error of the mean (s.e.m.).…”

Section: Methodsmentioning

confidence: 99%

Pannexin1 Stabilizes Synaptic Plasticity and Is Needed for Learning

et al. 2012

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Pannexin 1 (Panx1) represents a class of vertebrate membrane channels, bearing significant sequence homology with the invertebrate gap junction proteins, the innexins and more distant similarities in the membrane topologies and pharmacological sensitivities with gap junction proteins of the connexin family. In the nervous system, cooperation among pannexin channels, adenosine receptors, and KATP channels modulating neuronal excitability via ATP and adenosine has been recognized, but little is known about the significance in vivo. However, the localization of Panx1 at postsynaptic sites in hippocampal neurons and astrocytes in close proximity together with the fundamental role of ATP and adenosine for CNS metabolism and cell signaling underscore the potential relevance of this channel to synaptic plasticity and higher brain functions. Here, we report increased excitability and potently enhanced early and persistent LTP responses in the CA1 region of acute slice preparations from adult Panx1−/− mice. Adenosine application and N-methyl-D-aspartate receptor (NMDAR)-blocking normalized this phenotype, suggesting that absence of Panx1 causes chronic extracellular ATP/adenosine depletion, thus facilitating postsynaptic NMDAR activation. Compensatory transcriptional up-regulation of metabotropic glutamate receptor 4 (grm4) accompanies these adaptive changes. The physiological modification, promoted by loss of Panx1, led to distinct behavioral alterations, enhancing anxiety and impairing object recognition and spatial learning in Panx1−/− mice. We conclude that ATP release through Panx1 channels plays a critical role in maintaining synaptic strength and plasticity in CA1 neurons of the adult hippocampus. This result provides the rationale for in-depth analysis of Panx1 function and adenosine based therapies in CNS disorders.

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“…In our study we found the level of this hormone to increase considerably in both, embryos as well as in the newly hatched chicks exposed to electromagnetic field during incubation (Figure 4). The stress-inducing action of electromagnetic field was implicated in the studies with rats, where corticosterone concentrations were also observed to increase as a response to RF-EMF [17,28,29].…”

Section: Discussionmentioning

confidence: 99%

Plasma thyroid hormones and corticosterone levels in blood of chicken embryos and post hatch chickens exposed during incubation to 1800 MHz electromagnetic field

Pawlak¹,

Sechman²,

Nieckarz³

2014

International Journal of Occupational Medicine and Environmental Health

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Introduction: This study attempted to determine the effect of a 1800 MHz electromagnetic field (EMF) (only carrier frequency) on thyroxine (T 4 ), triiodothyronine (T 3 ) and corticosterone (CORT) concentrations in the blood plasma of chick embryos, and to investigate the effect of electromagnetic field (EMF) exposure during embryogenesis on the level of these hormones in birds that are ready for slaughter. Material and Methods: Throughout the incubation period, embryos from the experimental group were exposed to a 1800 MHz EMF with power density of 0.1 W/m 2 , 10 times during 24 h for 4 min. Blood samples were collected to determine T 4 , T 3 and CORT concentrations on the 12th (E12) and 18th (E18) day of incubation, from newly hatched chicks (D1) and from birds ready for slaughter (D42). Results: The experiment showed that T 4 and T 3 concentrations decreased markedly and CORT levels increased in the embryos and in the newly hatched chicks exposed to EMF during embryogenesis. However, no changes were found in the level of the analyzed hormones in the birds ready for slaughter. Differences in T 4 and T 3 plasma concentrations between the EMF-exposed group and the embryos incubated without additional EMF were the highest in the newly hatched chicks, which may be indicative of the cumulative effect of electromagnetic field on the hypothalamo-pituitary-thyroid axis (HPT). Discussion: The obtained results suggest that additional 1800 MHz radio frequency electromagnetic field inhibits function of HPT axis, however, it stimulates hypothalamo-pituitary-adrenal axis by inducing adrenal steroidogenic cells to synthesize corticosterone. Further investigations are needed to elucidate the mechanisms by which radio EMFs affect HPT and HPA axis function in the chicken embryos. Key words: Electromagnetic fields, Mobile phone, Thyroid hormone, Corticosterone, Chicken embryoThis study was performed under the project NN311536340 Chicken embryo as a model in the studies on the influence of radio frequency electromagnetic fields on the embryogenesis process and DS 3210/KHDZFiZ. Manager of project: Krzysztof Pawlak, PhD.

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Electromagnetic Field Effect or Simply Stress? Effects of UMTS Exposure on Hippocampal Longterm Plasticity in the Context of Procedure Related Hormone Release

Cited by 26 publications

References 73 publications

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Effects of 900MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

Pannexin1 Stabilizes Synaptic Plasticity and Is Needed for Learning

Plasma thyroid hormones and corticosterone levels in blood of chicken embryos and post hatch chickens exposed during incubation to 1800 MHz electromagnetic field

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