Electromagnetic Fields and Neurodegenerative Diseases

Wyszkowska, Joanna; Jankowska, Milena; Gas, Pacific

doi:10.15199/48.2019.01.33

Cited by 22 publications

(16 citation statements)

References 45 publications

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“…Some of these important factors include modulating waveform (potential excitation signal, Ψ), time interval, frequency, and amplitude of the triggering waveform 17 . At this condition, every arrhythmia and deviation from the normal characteristics of this harmony can be considered as the risk factors about the neuronal diseases via the neuronal electrical regulation process 18 .…”

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confidence: 99%

Mechanism behind the neuronal ephaptic coupling during synchronizing by specific brain-triggered wave as neuronal motor toolkit

Karami

Doroodmand

Taherianfar

et al. 2021

Sci Rep

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Probable mechanism behind the neuronal ephaptic coupling is investigated based on the introduction of “Brain”-triggered potential excitation signal smartly with a specific very low frequency (VLF) waves as a neuronal motor toolkit. Detection of this electric motor toolkit is attributed to in-vitro precise analyses of a neural network of snail, along to the disconnected snail’s neuronal network as a control. This is achieved via rapid (real-time) electrical signals acquisition by blind patch-clamp method during micro-electrode implanting in the neurons at the gigaseal conditions by the surgery operations. This process is based on its waveform (potential excitation signal) detection by mathematical curve fitting process. The characterized waveform of this electrical signal is “Saw Tooth” that is smartly stimulated, alternatively, by the brain during triggering the action potential’s (AP’s) hyperpolarization zone at a certain time interval at the several µs levels. Triggering the neuron cells results in (1) observing a positive shift (10.0%, depending on the intensity of the triggering wave), and (2) major promotion in the electrical current from sub nano (n) to micro (µ) amper (nA, µA) levels. Direct tracing the time domain (i.e., electrical signal vs. time) and estimation of the frequency domain (diagram of electrical response vs. the applied electrical frequencies) by the “Discrete Fast Fourier Transform” algorithm approve the presence of bilateral and reversible electrical currents between axon and dendrite. This mechanism therefore opens a novel view about the neuronal motor toolkit mechanism, versus the general knowledge about the unilateral electrical current flow from axon to dendrite operations in as neural network. The reliability of this mechanism is evaluated via (1) sequential modulation and demodulation of the snail’s neuron network by a simulation electrical functions and sequentially evaluation of the neuronal current sensitivity between pA and nA (during the promotion of the signal-to-noise ratio, via averaging of 30 ± 1 (n = 15) and recycling the electrical cycles before any neuronal response); and (2) operation of the process on the differentiated stem cells. The interstice behavior is attributed to the effective role of Ca2+ channels (besides Na+ and K+ ionic pumping), during hyper/hypo calcium processes, evidenced by inductively coupled plasma as the selected analytical method. This phenomenon is also modeled during proposing quadrupole well potential levels in the neuron systems. This mechanism therefore points to the microprocessor behavior of neuron networks. Stimulation of the neuronal system based on this mechanism, not only controls the sensitivity of neuron electrical stimulation, but also would open a light window for more efficient operating the neuronal connectivity during providing interruptions by phenomena such as neurolysis as well as an efficient treatment of neuron-based disorders.

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confidence: 99%

Mechanism behind the neuronal ephaptic coupling during synchronizing by specific brain-triggered wave as neuronal motor toolkit

Karami

Doroodmand

Taherianfar

et al. 2021

Sci Rep

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show abstract

“…Nevertheless, several studies have reported that EMF could affect brain function leading to mental and various types of neurological disorders (Pall, 2016;Terzi, Ozberk, Deniz, & Kaplan, 2016;Wyszkowska, Jankowska, & Gas, 2019). Moreover, in our previous studies, we have shown the deleterious effects of exposure to 900 MHz radiofrequency waves (RFW) on brain function including memory impairment and oxidative damage (Akbari, Jelodar, & Nazifi, 2014;Azimzadeh et al, 2018).…”

Section: Introductionmentioning

confidence: 94%

Trace elements homeostasis in brain exposed to 900 MHz RFW emitted from a BTS‐antenna model and the protective role of vitamin E

Azimzadeh

Jelodar

2020

Animal Physiology Nutrition

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Advances in telecommunication and their broad usage in the community have become a great concern from the health aspect. The object of the present study was to examine the effects of exposure to 900 MHz RFW on brain Iron (Fe), Copper (Cu), Zinc (Zn) and Manganese (Mn) concentration, and the protective role of pre‐treatment of vitamin E on mentioned elements homoeostasis. Twenty adult male Sprague–Dawley rats (200 ± 20 g) randomly were divided into four groups. Control group (without any exposure, received distilled water), treatment control group (orally received 250 mg/kg BW/d vitamin E), treatment group (received 250 mg/kg BW/d vitamin E and exposed to 900 MHz RFW) and sham‐exposed group (exposed to 900 MHz RFW). Animals (with freely moving in the cage) were exposed to RFW for 30 consecutive days (4 hr/day). The levels of the above mentioned elements in the brain tissue were determined on the last day using atomic absorption spectrophotometry. Exposure to 900 MHz RFW induced a significant increase in the Fe, Cu, Mn levels and Cu/Zn ratio accompanied by a significant decrease in Zn level in the sham‐exposed group compare to control group. Vitamin E pre‐treatment improved the level of Fe, Cu, Mn and Cu/Zn ratio, except in the Zn concentration. Exposure to 900 MHz RFW caused disrupted trace elements homoeostasis in the brain tissue and administration of vitamin E as an antioxidant and neuroprotective agent improved the situation.

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“…Stimulation of the deep brain has shown outstanding performance for people with neurological problems such as Parkinson’s disease, essential tremor and so on [1]. Currently, the simulation method has been deployed using permanently implanted electrodes [2] and chemicals [3], acoustic [4], electromagnetic [5], or optical [6] signals.…”

Section: Introductionmentioning

confidence: 99%

Theoretical Analysis for Wireless Magnetothermal Deep Brain Stimulation Using Commercial Nanoparticles

Bui

Yoon

2019

IJMS

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A wireless magnetothermal stimulation (WMS) is suggested as a fast, tetherless, and implanted device-free stimulation method using low-radio frequency (100 kHz to 1 MHz) alternating magnetic fields (AMF). As magnetic nanoparticles (MNPs) can transduce alternating magnetic fields into heat, they are targeted to a region of the brain expressing the temperature-sensitive ion channel (TRPV1). The local temperature of the targeted area is increased up to 44 °C to open the TRPV1 channels and cause an influx of Ca2+ sensitive promoter, which can activate individual neurons inside the brain. The WMS has initially succeeded in showing the potential of thermomagnetics for the remote control of neural cell activity with MNPs that are internally targeted to the brain. In this paper, by using the steady-state temperature rise defined by Fourier’s law, the bio-heat equation, and COMSOL Multiphysics software, we investigate most of the basic parameters such as the specific loss power (SLP) of MNPs, the injection volume of magnetic fluid, stimulation and cooling times, and cytotoxic effects at high temperatures (43–44 °C) to provide a realizable design guideline for WMS.

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Electromagnetic Fields and Neurodegenerative Diseases

Cited by 22 publications

References 45 publications

Mechanism behind the neuronal ephaptic coupling during synchronizing by specific brain-triggered wave as neuronal motor toolkit

Mechanism behind the neuronal ephaptic coupling during synchronizing by specific brain-triggered wave as neuronal motor toolkit

Trace elements homeostasis in brain exposed to 900 MHz RFW emitted from a BTS‐antenna model and the protective role of vitamin E

Theoretical Analysis for Wireless Magnetothermal Deep Brain Stimulation Using Commercial Nanoparticles

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