Electron beam intraoperative radiation therapy (EBIORT) for localized pancreatic carcinoma

Kawamura, Masashi; Kataoka, Makoto; Fujii, Takashi; Itoh, Hisao; Ishine, Masahiro; Hamamoto, Ken; Yokoyama, Shinji; Takashima, Shigemitsu; Satoh, Motomichi; Inoue, Kenji

doi:10.1016/0360-3016(92)90648-2

Cited by 20 publications

(11 citation statements)

References 23 publications

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“…Considering that EBRT alone was insufficient to achieve local control, IORT + EBRT is an attractive treatment modality to reduce local failure in patients with unresectable pancreatic cancer. Although the efficacy of IORT for favorable local control, the optimal use of IORT, such as doses and the combination of EBRT, has not been clarified (7,(19)(20)(21). For unresectable pancreatic cancer, IORT has generally been used as a boost to EBRT because the results of IORT alone are not encouraging (19,20).…”

Section: Discussionmentioning

confidence: 98%

“…Although the efficacy of IORT for favorable local control, the optimal use of IORT, such as doses and the combination of EBRT, has not been clarified (7,(19)(20)(21). For unresectable pancreatic cancer, IORT has generally been used as a boost to EBRT because the results of IORT alone are not encouraging (19,20). In the current study, patients treated with IORT, with or without, EBRT (median IORT dose, 25 Gy) had a statistically significantly higher local control than those treated with IORT alone (median IORT dose, 25 Gy) and the 2-year local control rates in patients treated with IORT, with or without, EBRT was 50.9% (Table 5).…”

Section: Discussionmentioning

confidence: 99%

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Intraoperative Radiotherapy for Unresectable Pancreatic Cancer: A Multi-Institutional Retrospective Analysis of 144 Patients

Ogawa¹,

Kiura²,

Ito³

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Intraoperative Radiotherapy for Unresectable Pancreatic Cancer: A Multi-Institutional Retrospective Analysis of 144 Patients

Ogawa¹,

Kiura²,

Ito³

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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“…Fifteen independent eligible studies [10,14,15,[22][23][24][25][26][27][28][29][30][31][32][33] were included in the analysis, these studies included 834 patients who underwent pancreatic resection with IORT (n = 401) or without IORT (n = 433). The studies were published between January 1971 and February 2019.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

The role of intraoperative radiation therapy in resectable pancreatic cancer: a systematic review and meta-analysis

et al. 2020

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Purpose: Several studies investigating the role of intraoperative radiotherapy (IORT) in the treatment of resectable pancreatic cancer (PC) have been published; however, their results remain inconsistent. By conducting a systematic review and meta-analysis, this study aimed to compare clinical outcomes in patients with resectable PC who underwent surgery with or without IORT. Methods and materials:The MEDLINE/PubMed, EMBASE, and Cochrane Library databases were searched to identify relevant studies published up to February 28, 2019. The main outcome measures included median survival time (MST), local recurrence (LR), postoperative complications, and operation-related mortality. Pooled effect estimates were obtained by performing a random-effects meta-analysis. Results: A total of 1095 studies were screened for inclusion, of which 15 studies with 834 patients were included in the meta-analysis. Overall, 401 patients underwent pancreatic resection with IORT and 433 underwent surgery without IORT. The pooled analysis revealed that IORT group experienced favorable overall survival (median survival rate [MSR], 1.20; 95% confidence interval [CI], 1.06-1.37, P = 0.005), compared with patients who did not receive IORT. Additionally, the pooled data showed a significantly reduced LR rate in the IORT group compared with that in the non-IORT group (relative risk [RR], 0.70; 95% CI, 0.51-0.97, P = 0.03). The incidences of postoperative complications (RR, 0.95; 95% CI, 0.73-1.23) and operation-related mortality (RR, 1.07; 95% CI, 0.44-2.63) were similar between the IORT and non-IORT groups.Conclusion: IORT significantly improved locoregional control and overall survival in patients with resectable PC, without increasing postoperative complications and operation-related mortality rates.

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“…Despite advances in diagnostic modalities and surgical techniques, most pancreatic cancers are unresectable because of either local tumor invasion or metastatic disease. Intraoperative radiotherapy (IORT) combined with external beam radiotherapy (EBRT) is a promising treatment for unresectable but localized pancreatic cancer (1)(2)(3)(4)(5)(6)(7). Although pancreatic cancer is considered radioresistant, computed tomography (CT) of some unresectable pancreatic tumors has revealed significant regression following radiotherapy.…”

Section: Original Articlementioning

confidence: 99%

Tumor Response and Patterns of Failure Following Intraoperative Radiotherapy for Unresectable Pancreatic Cancer: Evaluation by Computed Tomography

et al. 1999

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Tumor response and patterns of failure following intraoperative radiotherapy (IORT) of 42 patients with unresectable pancreatic cancers were evaluated by computed tomography (CT). At the time of maximum tumor regression, the tumor response rate following IORT was 52%, with three tumors showing CR. The median time of maximum tumor regression was 3 months after IORT. When tumor response was evaluated within 2 months of IORT, no significant difference in survival rate between responders and non-responders was noted. However, when tumor response was evaluated 3-6 months after IORT, the responders showed a significantly better survival rate than the non-responders. Local tumor recurrence, liver metastasis, and peritoneal dissemination were major causes of failure after IORT for unresectable pancreatic cancers. In addition, the median time of detection of these findings by CT was 2-3 months after IORT. Thus, our results indicate that CT performed 3-4 months after IORT is most important for predicting clinical outcome.

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Electron beam intraoperative radiation therapy (EBIORT) for localized pancreatic carcinoma

Cited by 20 publications

References 23 publications

Intraoperative Radiotherapy for Unresectable Pancreatic Cancer: A Multi-Institutional Retrospective Analysis of 144 Patients

Intraoperative Radiotherapy for Unresectable Pancreatic Cancer: A Multi-Institutional Retrospective Analysis of 144 Patients

The role of intraoperative radiation therapy in resectable pancreatic cancer: a systematic review and meta-analysis

Tumor Response and Patterns of Failure Following Intraoperative Radiotherapy for Unresectable Pancreatic Cancer: Evaluation by Computed Tomography

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