“…The earliest implication of mononuclear cell involvement in some forms of glomerulonephritis emerged from electron microscopic observations of cells resembling monocytes and macrophages in a variety of human glomerulonephritides [26,35,38,39,51] and in experimental nephritis in the rabbit [25,27,43,50], rat [49], and mouse [28,40]. Such cells were particularly prominent in glomerular crescents.…”