Electron microscopic study of signet-ring cells in diffuse carcinoma of the human stomach

Yamashiro, Kazuyoshi; Suzuki, Harumi; Nagayo, Takeo

doi:10.1007/bf00432651

Cited by 44 publications

(16 citation statements)

References 9 publications

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“…This finding is also consistent with a recent report that ANXA10 is downregulated in esophageal adenocarcinoma compared with Barrett's esophagus, 51 in which the esophageal mucosa is replaced by gastric mucosa. Our findings support the concept of two distinct histogenetic pathways of GC 47–49 . We suggest that ANXA10 can serve as a marker of a subset of GC, in particular, DGC, and its loss correlates with the deviation of tumor cells from gastric differentiation.…”

Section: Discussionsupporting

confidence: 86%

Expression and prognostic significance of gastric‐specific annexin A10 in diffuse‐ and intestinal‐type gastric carcinoma

Chen

Shun

et al. 2010

J of Gastro and Hepatol

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Section: Discussionsupporting

confidence: 86%

Expression and prognostic significance of gastric‐specific annexin A10 in diffuse‐ and intestinal‐type gastric carcinoma

Chen

Shun

et al. 2010

J of Gastro and Hepatol

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“…It showed a rate of lymph node metastasis similar to or higher than other types of gastric carcinoma [7,9], unlike advanced cancer, early gastric carcinoma with SRC has a significantly lower lymph node metastasis rate than other histology [11].…”

Section: Discussionmentioning

confidence: 77%

“…Advanced gastric carcinoma with SRC is characterized by the potential to infiltrate the gastric wall diffusely, and a higher rate of peritoneal dissemination than non-SRC [9,10]. It showed a rate of lymph node metastasis similar to or higher than other types of gastric carcinoma [7,9], unlike advanced cancer, early gastric carcinoma with SRC has a significantly lower lymph node metastasis rate than other histology [11].…”

Section: Discussionmentioning

confidence: 96%

Complete Pathologic Response in Advanced Primary Gastric Signet-Ring Cell Carcinoma: A Case Report

Akasbi¹,

Arifi²,

Ousadden³

et al. 2011

JCST

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Background: Gastric signet ring cell carcinoma (SRC) is a poorly differentiated adenocarcinoma in which the tumour cells invade singly or in small groups.The incidence of SRC has been reported in china as 13.9% (662 patients of 4,759) [1]. It is reported to occur more frequent among women and young patients.A regimen of epirubicin, cisplatin, and infused fluorouracil (ECF) improves survival among patients with incurable locally advanced or metastatic gastric adenocarcinoma. Case presentation:A 38-year-old female presented with a 3 weeks history of epigastralgia. Her medical history was unremarkable. The endoscopic findings of the stomach revealed an infiltrative lesion, which the guided biopsy yielded a positive pathologic diagnosis of signet ring cell carcinoma. Diagnostic imaging with an abdominal computed tomography (CT) scan revealed a gastric thickening, with lymph nodes. Induction chemotherapy was recommended, based on 6 cycles of ECX (Epirubicin 50 mg/m 2 , Cisplatin 60 mg/m 2 , Capecitabine 625 mg/m 2 ). The total gastrectomy specimen showed a pathological complete response.The patient, who is always followed in consultation, is in complete remission 19 months after the diagnosis. Conclusion:SRC is a distinctive histological type of gastric cancer. The ECX or EOX (epirubicin, oxaliplatine, capecitabine) remains the standard treatment of advanced primary gastric signet-ring cell carcinoma.Our case illustrates a complete pathologic response to ECX, which confirmed the effectiveness of this protocol on this histology.

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“…SRCC is usually presented with infiltration of the gastric wall diffusely. It also has a tendency for more extensive and infiltrative growth, lymph node and distant metastasis including peritoneal dissemination [9,10]. It is usually classified as poorly-differentiated tumor.It is most commonly located in antral region.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of the Gastric Signet Ring Cell Carcinoma Including CA 19-9, CEA and CRP Levels

Abuoglu¹

2015

J Cancer Sci Ther

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Aim: The aim of this study was to evaluate the clinicopathological features and prognosis of gastric Signet Ring Cell Carcinoma (SRCC) including measurement of tumor markers (CEA, CA 19-9) and CRP. Material and method:There were 19 patients with histopathological diagnosis of signet ring cell carcinoma of the stomach. Clinicopathological parameters, including gender and age of the patients, duration of symptoms, size and location of tumors, depth of invasion (T stage), lymph node metastasis status (N stage), distant metastasis (M status) and operative details, were collected retrospectively. CEA, CA 19-9 and CRP levels were measured in all patients. Results:The mean age of the patients was 63.74 ± 15.07 (range 37-90 years). Median survival time was 17.4 ± 10.7 month (range 4-48 months). The mean CA 19-9 level was 14.4 ± 23.1 (0.8-101.6), CEA level was 91.9 ± 227.2 (0.46-989) and CRP level was 1.79 ± 1.19 (0.3-3.7). Sixteen patients were classified as stage III or IV disease. Five patients were operated with total gastrectomy and 9 patients with gastroenterostomy due to unresectable tumor. Conclusion:Clinicopathological behavior of gastric SRCC is still debated. In this serial, most of the patients with gastric SRCC were diagnosed and treated in last stages of their diseases. Although CA 19-9 and CEA levels were inceased in some patients with SRCC, diagnostic value of these markers is debated.Another marker CRP was found normal in most of the patients with gastric SRCC in this serial.

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Electron microscopic study of signet-ring cells in diffuse carcinoma of the human stomach

Cited by 44 publications

References 9 publications

Expression and prognostic significance of gastric‐specific annexin A10 in diffuse‐ and intestinal‐type gastric carcinoma

Expression and prognostic significance of gastric‐specific annexin A10 in diffuse‐ and intestinal‐type gastric carcinoma

Complete Pathologic Response in Advanced Primary Gastric Signet-Ring Cell Carcinoma: A Case Report

Clinical Features of the Gastric Signet Ring Cell Carcinoma Including CA 19-9, CEA and CRP Levels

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