This article examines the tensions, communal processes, and narrative frameworks behind producing collective racial politics across differences. As digital media objects, the Asian American Feminist Collective’s zine Asian American Feminist Antibodies: Care in the Time of Coronavirus and corresponding #FeministAntibodies Tweetchat responds directly to and anticipates a social media and information environment that has racialized COVID-19 in the language of Asian-ness. Writing from an autoethnographical perspective and using collaborative methods of qualitative discourse analysis as feminist scholars, media-makers, and interlocuters, this article looks toward the technological infrastructures, social economies, and material forms of Asian American digital media-making in the midst of the COVID-19 pandemic.