Electron tomography and nano-diffraction enabling the investigation of individual magnetic nanoparticles inside fibers of MR visible implants

Slabu, Ioana; Wirch, N.; Caumanns, Tobias; Theissmann, Ralf; Krüger, Michael; Weirich, Thomas E.

doi:10.1088/1361-6463/aa77e8

Cited by 7 publications

(6 citation statements)

References 40 publications

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“…Similar to magnetic scaffolds, immobilization and agglomeration of MNP inside hybrid materials and filaments used for the design of implants change their heating properties. The presence of MNP agglomerates inside filaments after a melt-spinning process was reported before [18]. In this case, MNP are fully immobilized, and Brownian rotation can be considered as blocked.…”

Section: Introductionmentioning

confidence: 66%

“…An investigation of the crystal structure of MNP inside the polymer matrix by XRD measurements is not possible. For that, extensive electron energy loss measurements are necessary [ 18 ]. However, the Bragg angles and their corresponding FWHM values were used to determine a weighted average of the crystal size d cryst = (9.5 ± 0.4) nm (see Supplementary Materials S4 Table S4 ).…”

Section: Resultsmentioning

confidence: 99%

“…The technology of nanoparticle incorporation into textiles enhancing their functionality such as UV resistance, antimicrobial properties, or magnetic guidance was reported previously [ 15 , 16 , 17 ]. MNP inside implant materials were used before as contrast agents to visualize implant structure and functionality with magnetic resonance imaging (MRI) [ 18 , 19 , 20 ]. Such engineered materials loaded with MNP are also known as magnetic scaffolds.…”

Section: Introductionmentioning

confidence: 99%

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Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors

et al. 2021

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This paper describes a magnetic nanotechnology that locally enables hyperthermia treatment of hollow organ tumors by using polymer hybrid stents with incorporated magnetic nanoparticles (MNP). The hybrid stents are implanted and activated in an alternating magnetic field to generate therapeutically effective heat, thereby destroying the tumor. Here, we demonstrate the feasibility of nanomagnetic actuation of three prototype hybrid stents for hyperthermia treatment of hollow organ tumors. The results show that the heating efficiency of stent filaments increases with frequency from approximately 60 W/gFe (95 kHz) to approximately 250 W/gFe (270 kHz). The same trend is observed for the variation of magnetic field amplitude; however, heating efficiency saturates at approximately 30 kA/m. MNP immobilization strongly influences heating efficiency showing a relative difference in heating output of up to 60% compared to that of freely dispersed MNP. The stents showed uniformly distributed heat on their surface reaching therapeutically effective temperatures of 43 °C and were tested in an explanted pig bile duct for their biological safety. Nanomagnetic actuation of hybrid stents opens new possibilities in cancer treatment of hollow organ tumors.

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Section: Introductionmentioning

confidence: 66%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors

et al. 2021

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“…Because of their superior magnetic properties, MNMPs were used as additives for the development of smart implants with advanced sensing and actuator characteristics. − …”

Section: Assembly Of Mnmps For Theranostic Applicationsmentioning

confidence: 99%

“…Hence, MNMPs can facilitate a multifunctional approach toward different disease pathologies, such as cancer, providing accurate information for tumor diagnosis and precise treatment. , In addition, MNMPs have tremendously contributed to the design of stimuli-responsive materials for medical applications. Because of their superior magnetic properties, MNMPs have been used as additives for the development of smart implants with advanced sensing and actuator characteristics. − …”

Section: Introductionmentioning

confidence: 99%

Recent Advancements of Specific Functionalized Surfaces of Magnetic Nano- and Microparticles as a Theranostics Source in Biomedicine

Zheng

Schumacher

et al. 2021

ACS Biomater. Sci. Eng.

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Magnetic nano-and microparticles (MNMPs) belong to a highly versatile class of colloids with actuator and sensor properties that have been broadly studied for their application in theranostics such as molecular imaging and drug delivery. The use of advanced biocompatible, biodegradable polymers and polyelectrolytes as MNMP coating materials is essential to ensure the stability of MNMPs and enable efficient drug release while at the same time preventing cytotoxic effects. In the past years, huge progress has been made in terms of the design of MNMPs. Especially, the understanding of coating formation with respect to control of drug loading and release kinetics on the molecular level has significantly advanced. In this review, recent advancements in the field of MNMP surface engineering and the applicability of MNMPs in research fields of medical imaging, diagnosis, and nanotherapeutics are presented and discussed. Furthermore, in this review the main emphasis is put on the manipulation of biological specimens and cell trafficking, for which MNMPs represent a favorable tool enabling transport processes of drugs through cell membranes. Finally, challenges and future perspectives for applications of MNMPs as theranostic nanomaterials are discussed.

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Magnetic Force Microscopy and Magnetic Nanoparticles: Perspectives and Challenges

Passeri

Angeloni

Rossi

2021

Springer Series in Materials Science

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Electron tomography and nano-diffraction enabling the investigation of individual magnetic nanoparticles inside fibers of MR visible implants

Cited by 7 publications

References 40 publications

Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors

Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors

Recent Advancements of Specific Functionalized Surfaces of Magnetic Nano- and Microparticles as a Theranostics Source in Biomedicine

Magnetic Force Microscopy and Magnetic Nanoparticles: Perspectives and Challenges

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