Electron transfer studies on cholesterol LB films assembled on thiophenol and 2-naphthalenethiol self-assembled monolayers

Pandey, Rakesh K.; Suresh, K. A.; Lakshminarayanan, V.

doi:10.1016/j.jcis.2007.07.044

Cited by 15 publications

(9 citation statements)

References 34 publications

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“…2-Naphthalenethiol (2-NT), composed of two consecutive benzene rings (hydrophobic unit) with a thiol side group, is soluble and can self-assemble on a Au surface through the chemisorption of thiols. 24 This aromatic thiol has been used as a capping ligand on Au nanoparticles in fabricating memory devices and the device shows a less abrupt switching behavior than the one capped with an insulating ligand due to its conductive property. 25 Compared with other self-assembled molecules reported for organic layer deposition, 22,23,26,27 2-NT has a relatively simple chemical structure, is less costly, has a small molecular size and, most importantly, it is conductive.…”

Section: Introductionmentioning

confidence: 99%

Enhanced charge transport in hybrid polymer/ZnO-nanorod solar cells assisted by conductive small molecules

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Enhanced charge transport in hybrid polymer/ZnO-nanorod solar cells assisted by conductive small molecules

et al. 2012

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“…The PyTp film was deposited on unmodified gold and also on thiophenol self‐assembled monolayer (TP SAM) modified gold. In our earlier studies, we have shown that TP SAM surface was an ideal hydrophobic platform for the deposition of the Langmuir‐Blodgett film . The LB film of PyTp on unmodified gold does not show any barrier property towards the electron transfer reaction of potassium ferrocyanide and ferricyanide (Figure a, 4a).…”

Section: Resultsmentioning

confidence: 91%

“…The superior LB deposition on TP SAM is because of the hydrophobic nature of the TP SAM which is a suitable platform for the deposition of the hydrophobic PyTp. TP SAM is useful in the electrochemical point of view also because it does not show any electron transfer barrier property in potassium ferrocyanide/ferricyanide, therefore, we can study the electron transfer barrier property of the subsequently deposited films on TP SAM …”

Section: Resultsmentioning

confidence: 99%

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Electrochemical Charge Transfer Through the Supramolecular Discogen‐DNA Hybrid Multi‐layered Assembly

Pandey

Pandey²,

Nayak

2018

ChemistrySelect

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In the present work, charge transfer phenomenon through the films of an ionic discotic liquid crystal (discogen) that is pyridinium tethered with hexaalkoxytriphenylene (PyTp) and its complex with DNA (PyTp-DNA) was studied by using electrochemical methods. The PyTp and PyTp-DNA hybrid films were first formed at the air-water interface and then transferred onto the gold substrates by Langmuir-Blodgett (LB) technique. Electrochemical measurements carried out on these films in three different redox systems, namely, ferrocene, hexaammineruthenium (III), and ferrocyanide, revealed that the ferrocene and the hexaammineruthenium (III) systems allow the electron transfer reaction between redox probes and metal, whereas the ferrocyanide system completely blocks it. The electrochemical response of the films, in the former two systems, has been attributed to the bridge mediated electron transfer process, whereas, in the ferrocyanide system, the impermeability of redox ions through these LB films is responsible for the complete blocking of electron transfer. Based on the observed results, this work highlights the possibility of novel charge transfer properties of discogen-DNA type hybrid films for applications in molecular electronics.

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“…The cholesterol-based multilayer structure of amphiphilic molecules was also reported in the literature report. 50 Additionally, it should be noted that LDN swells by 92% rather than 100%, which possibly implies a complicated process, including the cross-talk of DNA components between layers. The measured data of DLS and macroscopic images clearly indicate that LDN is successfully constructed and does swell upon target-induced conformational rearrangement of Chol-DPs.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Swelling of Serum-Stable DNA Nanoparticles upon Target-Induced Conformational Rearrangement of Sensing Probes for the Signal-On Detection of Cancer-Related Genes

et al. 2022

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Nuclease-resistant assay probes are of significant importance for biochemical analysis and disease diagnosis. In this contribution, a reconfigurable lipidic moiety-attached DNA nanoparticle (LDN) is constructed from a cholesterol-conjugated multifunctional hairpin-type DNA probe (Chol-DP) by hydrophobicity-mediated self-assembly. The LDN holds high serum stability and displays a low false-positive signal even in a complex biological milieu. The hydrophobic cholesterol moiety enables the hydrophobicity-mediated assembly, while hydrophilic DNA sequence serves as a recognition element and a polymerization template. The initiator-activated strand displacement amplification (SDA) reaction can convert the hairpin-shaped probe into rigid double-stranded DNA (dsDNA), causing the conformational rearrangement-based LDN swelling that can be used to reliably and fluorescently signal the cancer-related p53 gene. The size increase and structural reconfiguration are confirmed by dynamic light scattering (DLS) analysis and confocal microscopy imaging, respectively. Target p53 is specifically detected down to 10 pM. The whole assay process involved only several simple mixing steps. Recovery test and blind test further confirm the feasibility of the use of the LDN for the detection of target DNA in a complex biological milieu, indicating a promising nanotool for biomedical applications.

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Electron transfer studies on cholesterol LB films assembled on thiophenol and 2-naphthalenethiol self-assembled monolayers

Cited by 15 publications

References 34 publications

Enhanced charge transport in hybrid polymer/ZnO-nanorod solar cells assisted by conductive small molecules

Enhanced charge transport in hybrid polymer/ZnO-nanorod solar cells assisted by conductive small molecules

Electrochemical Charge Transfer Through the Supramolecular Discogen‐DNA Hybrid Multi‐layered Assembly

Swelling of Serum-Stable DNA Nanoparticles upon Target-Induced Conformational Rearrangement of Sensing Probes for the Signal-On Detection of Cancer-Related Genes

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