Nanoparticles(NPs) are of particle sizes lesser than 100nm and are insoluble the field which deal with the handling of these particles is coined as “Nanotechnology” as their particle size is smaller, they can penetrate easily therefore they are applied in various medical fields, drug delivery and in dentistry as they have antimicrobial property, reduces friction, anti-inflammatory and antioxidant property. Many studies have been done to evaluate its application and its cytotoxicity by varying its concentration and various studies have been done to evaluate its physical property. Therefore, it is of interest to describe concepts of nanoparticles, mode of action, tissue reaction and its application in orthodontics.