Electrophotoredox cerium-catalyzed decarboxylative radical cyclization cascade for the synthesis of alkylated benzimidazo-fused isoquinolinones

Abstract

We report here an electrophotoredox cerium-catalyzed ligand-to-metal-charge-transfer (LMCT) strategy to incorporate a broad range of primary, secondary and tertiary carboxylic acids into radical cyclization cascades under external oxidant-free conditions. This...

Unleashing the potentiality of metals: synergistic catalysis with light and electricity

“…Recently, Zeng et al reported a ligand-to-metal charge transfer (LMCT) strategy using cerium-catalyzed electro-photoredox reactions, enabling the incorporation of a broad range of primary, secondary, and tertiary carboxylic acids into radical cyclization cascades under external oxidant-free conditions. 47 This approach addresses the challenges associated with the synthesis of alkylated benzimidazo-fused isoquinolinones. The high functional group compatibility was demonstrated by the tolerance of ester, ketone, amide, sulfonyl, and hydroxyl groups (Scheme 14).…”

When transition-metal catalysis meets electrosynthesis: a recent update

“…24,25 In addition, transition-metal catalysis under electrophotochemical conditions is also excluded from this review because it represents another domain of organic synthesis. 26–32 The current review is organized based on metal catalysts, with specific focus placed on strategy design and mechanistic aspects.…”