Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism

Roy, Nikita; Barry, Robert J.; Fernández, Francisco Sousa; Lim, Chai K.; Al-Dabbas, Mahmoud A; Karamacoska, Diana; Broyd, Samantha J.; Solowij, Nadia; Chiu, Christine L; Steiner, Genevieve Z.

doi:10.1038/s41598-020-74780-9

Cited by 17 publications

(10 citation statements)

References 43 publications

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“…In these studies, COMT Val homozygotes were found to have lower a power than Met homozygotes (Bodenmann et al, 2009), and COMT polymorphism was found to influence phase-resetting of g oscillations in attention (Garcia-Garcia et al, 2017). Furthermore, BDNF has been implicated in resting-state oscillation amplitude differences in delta (0.5-3.5 Hz), a, and b bands but not in q band amplitudes (Roy et al, 2020) and in reduced g band FC between anterior and posterior regions in Val/Met compared to Val/Val participants (Rodrı ´guez- Rojo et al, 2018). We used here a data-driven approach for mapping the effects of COMT and BDNF polymorphism on both instantaneous oscillation amplitudes and their LRTCs from sourcereconstructed MEG data.…”

Section: Discussionmentioning

confidence: 95%

“…Prior observations about COMT and BDNF polymorphism effects on electrophysiological activity are scarce and mainly restricted to EEG and MEG sensor level (Bodenmann et al, 2009;Bonetti et al, 2021;Garcia-Garcia et al, 2017;Rodrı ´guez-Rojo et al, 2018;Roy et al, 2020). In these studies, COMT Val homozygotes were found to have lower a power than Met homozygotes (Bodenmann et al, 2009), and COMT polymorphism was found to influence phase-resetting of g oscillations in attention (Garcia-Garcia et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Simola¹,

Siebenhühner²,

Myrov³

et al. 2022

iScience

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Simola¹,

Siebenhühner²,

Myrov³

et al. 2022

iScience

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“…We could not examine the causal relationship between BNDF level and reduction in activity in patients with NAFLD in this study. Although the biological significance of BNDF in the reduction in activity remains unclear, BDNF has been reported to be modulated by various factors, including race [ 43 ], depressive symptoms [ 44 ], cognitive function [ 45 ], and genetic polymorphism [ 46 , 47 ]. These factors might be involved in the negative association between serum BDNF levels and activity in this study.…”

Section: Discussionmentioning

confidence: 99%

Association between Activity and Brain-Derived Neurotrophic Factor in Patients with Non-Alcoholic Fatty Liver Disease: A Data-Mining Analysis

Hashida

Nakano

Yamamura

et al. 2021

Life

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Reduction in activity links to the development and progression of non-alcoholic fatty liver disease (NAFLD). Brain-derived neurotrophic factor (BDNF) is known to regulate an activity. We aimed to investigate the association between reduction in activity and BDNF in patients with NAFLD using data-mining analysis. We enrolled 48 NAFLD patients. Patients were classified into reduced (n = 21) or normal activity groups (n = 27) based on the activity score of the Chronic Liver Disease Questionnaire-NAFLD/non-alcoholic steatohepatitis. Circulating BDNF levels were measured using an enzyme-linked immunoassay. Factors associated with reduced activity were analyzed using decision-tree and random forest analyses. A reduction in activity was seen in 43.8% of patients. Hemoglobin A1c and BDNF were identified as negative independent factors for reduced activity (hemoglobin A1c, OR 0.012, p = 0.012; BDNF, OR 0.041, p = 0.039). Decision-tree analysis showed that “BDNF levels ≥ 19.1 ng/mL” was the most important classifier for reduced activity. In random forest analysis, serum BDNF level was the highest-ranked variable for distinguishing between the reduced and normal activity groups (158 valuable importance). Reduced activity was commonly seen in patients with NAFLD. Data-mining analyses revealed that BNDF was the most important independent factor corresponding with the reduction in activity. BDNF may be an important target for the prevention and treatment of NAFLD.

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“…Met substitution damages the activity-dependent secretion and intracellular distribution of BDNF in hippocampal neurons ( 53 ). Compared with Val carriers, Met carriers have worse episodic memory and hippocampal function, and the gray matter volume of the prefrontal lobe and temporal lobe is smaller ( 54 ).…”

Section: Mechanism Of Aging and Neurodegenerative Diseases On Cogniti...mentioning

confidence: 99%

The physiological mechanism and effect of resistance exercise on cognitive function in the elderly people

Cheng

Zhang

Liu

et al. 2022

Front. Public Health

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BackgroundAs brain function declines and cognitive ability declines, the benefits of resistance exercise to the brain of older people are gradually gaining attention.ObjectiveThe purpose of this review is to explore the mechanism and relationship between physiological factors such as vascular and neuronal degeneration and cognitive decline, and to categorize the differences in the effects of an acute and chronic resistance exercise intervention on cognitive function in healthy elderly people and the possible regulators of cognitive effects.MethodsUsing PubMed, Elsevier, Web of Science, X-MOL, CNKI, and Taiwan academic literature database, the research papers published in relevant journals at home and abroad until April 2022 were searched with Chinese and English keywords such as Resistance exercise, the elderly, hippocampus, memory performance, neurons, cognitive function. Pedro scale was used to check the quality of various documents, and the relevant research documents were obtained with the resistance exercise elements as the main axis for comprehensive analysis.Results and conclusion(1) Resistance exercise can have a beneficial effect on the brain function of the elderly through blood flow changes, stimulate nerve conduction substances and endocrine metabolism, promote cerebrovascular regeneration and gray matter volume of the brain, and prevent or delay the cognitive function degradation such as memory and attention of the elderly; (2) Acute resistance can temporarily stimulate hormone secretion in vivo and significantly improve the effect of short-term memory test, but it has little effect on the cognitive performance of the elderly; (3) Moderate-high intensity resistance exercise (50–80%1RM, 1–3 times/week, 2–3 groups/time) lasting for at least 6 months is more prominent for the improvement of cognitive function of the elderly, while the parameters such as resistance exercise intensity, exercise amount, duration, evaluation test time and differences of subjects may have different degrees of influence on cognitive benefits.

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Electrophysiological correlates of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism

Cited by 17 publications

References 43 publications

Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

Association between Activity and Brain-Derived Neurotrophic Factor in Patients with Non-Alcoholic Fatty Liver Disease: A Data-Mining Analysis

The physiological mechanism and effect of resistance exercise on cognitive function in the elderly people

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