Electrophysiological study on the postnatal development of neuronal mechanisms in the rat cerebellar cortex

Shimono, T.; Nosaka, Schoichiro; Sasaki, Kohsuke

doi:10.1016/0006-8993(76)90186-4

Cited by 126 publications

(58 citation statements)

References 31 publications

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“…Previous in vivo studies have also followed developing Purkinje cells, showing that complex spike activity can be detected during the first week after birth in rats (Crepel 1971;Shimono et al 1976;Sokoloff et al 2014;Woodward et al 1969). More recently, whole cell in vivo electrophysiology conducted in developing mice also demonstrated complex spike activity in the first week of life (Kawamura et al 2013).…”

Section: Discussionmentioning

confidence: 96%

In vivo analysis of Purkinje cell firing properties during postnatal mouse development

Arancillo

White

Lin

et al. 2015

Journal of Neurophysiology

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Arancillo M, White JJ, Lin T, Stay TL, Sillitoe RV. In vivo analysis of Purkinje cell firing properties during postnatal mouse development. J Neurophysiol 113: 578 -591, 2015. First published October 29, 2014 doi:10.1152/jn.00586.2014.-Purkinje cell activity is essential for controlling motor behavior. During motor behavior Purkinje cells fire two types of action potentials: simple spikes that are generated intrinsically and complex spikes that are induced by climbing fiber inputs. Although the functions of these spikes are becoming clear, how they are established is still poorly understood. Here, we used in vivo electrophysiology approaches conducted in anesthetized and awake mice to record Purkinje cell activity starting from the second postnatal week of development through to adulthood. We found that the rate of complex spike firing increases sharply at 3 wk of age whereas the rate of simple spike firing gradually increases until 4 wk of age. We also found that compared with adult, the pattern of simple spike firing during development is more irregular as the cells tend to fire in bursts that are interrupted by long pauses. The regularity in simple spike firing only reached maturity at 4 wk of age. In contrast, the adult complex spike pattern was already evident by the second week of life, remaining consistent across all ages. Analyses of Purkinje cells in alert behaving mice suggested that the adult patterns are attained more than a week after the completion of key morphogenetic processes such as migration, lamination, and foliation. Purkinje cell activity is therefore dynamically sculpted throughout postnatal development, traversing several critical events that are required for circuit formation. Overall, we show that simple spike and complex spike firing develop with unique developmental trajectories.

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Section: Discussionmentioning

confidence: 96%

In vivo analysis of Purkinje cell firing properties during postnatal mouse development

Arancillo

White

Lin

et al. 2015

Journal of Neurophysiology

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“…The temporal sequence of formation of synapses in the cerebellar cortex is retrograde to the direction of synaptic transmission: the Purkinje cells send axons to the deep cerebellar nuclei before developing dendritic branches and receiving parallel fibre terminals; migrating granule cells make synaptic contact with Purkinje cell dendrites before reaching internal granular layers and receiving mossy fibre terminals; feed-back and feed-forward inhibition on the Purkinje cell by the Golgi, basket, and stellate cells have been established prior to emergence of excitation on the Purkinje cell via the mossy fibre-granule cell-parallel fibre synapses (Larramendi, 1969;Altman, 1972a, b;Sidman & Rakic, 1973;Shimono et al 1976). Exceptional to this retrograde order of formation is the functional development of the climbing fibre which begins sustained activity earlier than any other element (Woodward, Hoffer & Lapham, 1969).…”

Section: Discussionmentioning

confidence: 99%

“…In altricial animals such as the mouse, the rat and the cat, mitosis and migration of the granule cell and synaptogenesis of the neuronal circuitry in the * Present address: Department of Physiology, Fukui Medical School, 910-11 Fukui, Japan. S. KA WAGUCHI, A. SAMEJIMA AND T. YAMAMOTO cerebellar cortex are for the most part a post-natal occurrence on which a wealth of morphological and electrophysiological studies have been reported (Altman, 1972a, b;Jacobson, 1978;Shimono, Nosaka & Sasaki, 1976). However, the ontogenesis of the deep cerebellar nuclei and cerebellofugal system has not been well studied yet.…”

Section: Introductionmentioning

confidence: 99%

Post‐natal development of the cerebello‐cerebral projection in kittens.

Kawaguchi¹,

Samejima²,

Yamamoto³

1983

The Journal of Physiology

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SUMMARY1. Post-natal development of the cerebello-cerebral response was investigated in 126 kittens from birth to 142 days of age by analysis of laminar field potentials in the cerebral cortex; the thalamocortical projection mediating the cerebello-cerebral response was examined on four new-born and three one-month-old kittens by means of anterograde axonal transport of horseradish peroxidase.2. A marked response was evoked in the frontal motor cortex from birth and an appreciable response could be evoked in the parietal association cortex at 2 days after birth. The latency of response in the frontal cortex decreased sharply from birth till 3 weeks of age whereas that in the parietal cortex remained almost unchanged until 2 weeks of age. Maturation of the cerebello-cerebral projection, in every respect, proceeds earlier in the frontal cortex than in the parietal cortex.3. The cerebello-cerebral response in kittens at any age, like in adult cats, consisted of two types of elementary responses: one which is characterized by a surface positive-depth negative (s.p.-d.n.) wave and the other which is characterized by a surface negative-depth positive (s.n.-d.p.) wave. The response in the frontal cortex was a sequential occurrence of the two waves while the response in the parietal cortex was a pure form of the s.n.-d.p. wave. 4. Two types of thalamocortical projections corresponding to the two types of elementary responses were revealed: one is the projection mainly onto layer I which appears to mediate the s.n.-d.p. wave and the other is the projection mainly onto layer III which appears to mediate the s.p.-d.n. wave.5. Development of the cerebello-cerebral response and changes in the terminal distribution of the thalamocortical projection during maturation are consistent with the principle of ontogenesis of the mammalian neocortical organization, i.e. ascending sequential maturation.

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“…Do interneurons that have reached their Wnal destination signal-back to their brethren still en route and thereby impinge on the latter's migrational behaviour, e.g., by modulation of Purkinje cell output which would then be sensed by migratory cells in the nascent white matter? Functional integration of both Golgi and basket/stellate cells (i.e., inhibiton of granule cells and Purkinje cells, respectively), which would be a prerequisite for such a scenario, has been documented, in the rat, at about postnatal days 10-12, (Shimono et al 1976), i.e. at about midway during the formation of the molecular and granule cell layers.…”

Section: Migration Of Cerebellar Inhibitory Interneurons and Neuritogmentioning

confidence: 99%

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

Schilling

Oberdick

Rossi

et al. 2008

Histochem Cell Biol

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Ever since the groundbreaking work of Ramon y Cajal, the cerebellar cortex has been recognized as one of the most regularly structured and wired parts of the brain formed by a rather limited set of distinct cells. Its rather protracted course of development, which persists well into postnatal life, the availability of multiple natural mutants, and, more recently, the availability of distinct molecular genetic tools to identify and manipulate discrete cell types have suggested the cerebellar cortex as an excellent model to understand the formation and working of the central nervous system. However, the formulation of a unifying model of cerebellar function has so far proven to be a most cantankerous problem, not least because our understanding of the internal cerebellar cortical circuitry is clearly spotty. Recent research has highlighted the fact that cerebellar cortical interneurons are a quite more diverse and heterogeneous class of cells than generally appreciated, and have provided novel insights into the mechanisms that underpin the development and histogenetic integration of these cells. Here, we provide a short overview of cerebellar cortical interneuron diversity, and we summarize some recent results that are hoped to provide a primer on current understanding of cerebellar biology.

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Electrophysiological study on the postnatal development of neuronal mechanisms in the rat cerebellar cortex

Cited by 126 publications

References 31 publications

In vivo analysis of Purkinje cell firing properties during postnatal mouse development

In vivo analysis of Purkinje cell firing properties during postnatal mouse development

Post‐natal development of the cerebello‐cerebral projection in kittens.

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

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