Electropolymerized-molecularly imprinted polymers (E-MIPS) as sensing elements for the detection of dengue infection

Buensuceso, Clarisse E; Tiu, Brylee David B.; Lee, Luke P.; Sabido, Portia Mahal G.; Nuesca, Guillermo; Caldona, Eugene B.; Mundo, Florian R. del; Advíncula, Rigoberto C.

doi:10.1007/s00216-021-03757-y

Cited by 18 publications

(8 citation statements)

References 46 publications

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“…In the final results, geometrically fit imprinted sites for specific detection of the target analyte were generated. Dengue virus has been detected in other studies using MIP technology with conducting [ 119 ] and non-conducting [ 120 , 121 , 122 ] polymers. Buensuceso et al [ 119 ] designed an MIP-based sensor on gold-coated QCM crystal for dengue NS1 detection using a terthiophene-based monomer (G03TCOOH) for epitope-imprinting.…”

Section: Mip Application For the Detection Of Biomarkers Of Infectiou...mentioning

confidence: 98%

“…Dengue virus has been detected in other studies using MIP technology with conducting [ 119 ] and non-conducting [ 120 , 121 , 122 ] polymers. Buensuceso et al [ 119 ] designed an MIP-based sensor on gold-coated QCM crystal for dengue NS1 detection using a terthiophene-based monomer (G03TCOOH) for epitope-imprinting. Terthiophene compounds have low oxidation potential, which makes them ideal for electrochemical functionalization and modification.…”

Section: Mip Application For the Detection Of Biomarkers Of Infectiou...mentioning

confidence: 98%

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Molecularly Imprinted Polymer-Based Electrochemical Sensors for the Diagnosis of Infectious Diseases

et al. 2023

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The appearance of biological molecules, so-called biomarkers in body fluids at abnormal concentrations, is considered a good tool for detecting disease. Biomarkers are usually looked for in the most common body fluids, such as blood, nasopharyngeal fluids, urine, tears, sweat, etc. Even with significant advances in diagnostic technology, many patients with suspected infections receive empiric antimicrobial therapy rather than appropriate treatment, which is driven by rapid identification of the infectious agent, leading to increased antimicrobial resistance. To positively impact healthcare, new tests are needed that are pathogen-specific, easy to use, and produce results quickly. Molecularly imprinted polymer (MIP)-based biosensors can achieve these general goals and have enormous potential for disease detection. This article aimed to overview recent articles dedicated to electrochemical sensors modified with MIP to detect protein-based biomarkers of certain infectious diseases in human beings, particularly the biomarkers of infectious diseases, such as HIV-1, COVID-19, Dengue virus, and others. Some biomarkers, such as C-reactive protein (CRP) found in blood tests, are not specific for a particular disease but are used to identify any inflammation process in the body and are also under consideration in this review. Other biomarkers are specific to a particular disease, e.g., SARS-CoV-2-S spike glycoprotein. This article analyzes the development of electrochemical sensors using molecular imprinting technology and the used materials’ influence. The research methods, the application of different electrodes, the influence of the polymers, and the established detection limits are reviewed and compared.

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Section: Mip Application For the Detection Of Biomarkers Of Infectiou...mentioning

confidence: 98%

Section: Mip Application For the Detection Of Biomarkers Of Infectiou...mentioning

confidence: 98%

Molecularly Imprinted Polymer-Based Electrochemical Sensors for the Diagnosis of Infectious Diseases

et al. 2023

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“…Meanwhile, new materials for quick microbial detection, such as hydrogels and paper, have been incorporated into microfluidic circuits [Zhou et al, 2019]. Antibodies [Abafogi et al, 2020], antimicrobial peptides (AMPs) [Dao et al, 2018], aptamers [Su et al, 2020a], bacteriophages [Hussain et al, 2021], and molecularly imprinted polymers (MIPs) [Buensuceso et al, 2022] have all been exploited as functional coatings on the surface of microchannels.…”

Section: Microfluidic Technologiesmentioning

confidence: 99%

Targeted Cell Labeling and Sorting of Prokaryotes for Cultivation and Omics Approaches

Sturm,

Mojarrad,

Kaster

2023

Microb Physiol

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To date, the vast majority of prokaryotic organisms escapes detailed characterization because they cannot be isolated in axenic cultures. These organisms are referred to as microbial dark matter. Targeted labelling and sorting of these microorganisms pave the way for single-cell, enrichment, or cultivation approaches. In this review, we describe an array of different methods ranging from labeling-free to specific labelling techniques. In addition, different cell sorting methods and their combinations with targeting strategies are summarized and downstream applications like sequencing and cultivation are reviewed. Recent advances, challenges, and limitations of the particular methods are discussed with respect to cell viability, genome integrity as well as throughput, in order to help researchers select the most suitable methods for their specific research questions.

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“…Buensuceso et al 70 synthesized VHTWTEQYKFQ molecules imprinted polymer (VHTWTEQYKFQ-MIP) by using the dengue virus nonstructural protein 1 (NS1) epitope molecule Ac-VHTWTEQYKFQ-NH 2 as a template substance, synthesized (2,2 0 :5 0 ,2 00 -terthiophene)-3 0acetic acid [G03TCOOH] as a functional monomer, and a gold-plated QCM chip as a working electrode. Figure 10 shows the preparation of the imprinted polymers sensor membrane.…”

Section: Ultrasound Field-induced Imprinted Polymersmentioning

confidence: 99%

Research progress and perspectives in field‐induced imprinted polymers

Xu,

Ou,

Sun

et al. 2023

Polymers for Advanced Techs

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In the process of preparation of imprinted polymers, the introduction of external fields, such as magnetic field, microwave field, ultrasonic field, electric field and high‐energy radiation field, to improve the structure and performance of imprinted polymers has become a novel direction of the development of imprinted polymers, and relevant reports have been increasing in recent years. However, the progress of research on field‐induced imprinted polymers has not been summarized and noticed, resulting in few perspective on the shortcomings and future development of the field‐induced effect which in turn has hindered its further study. Considering this, we firstly introduced the development history and mechanism of imprinted polymers. Then, the field‐induced effects on the mechanism of polymerization and the structure and performances of imprinted polymers were summarized in the order of magnetic field‐induced imprinted polymers, microwave field‐induced imprinted polymers, ultrasonic field‐induced imprinted polymers, electric field‐induced imprinted polymers and high‐energy radiation field‐induced polymers. Significantly, the challenges to the development of field‐induced imprinted polymers were presented, and the development trends of field‐induced imprinted polymers were proposed with the aim to build the bridge for future FI‐IPs research and shed the light on the application research of the field‐induced imprinted polymers.

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Electropolymerized-molecularly imprinted polymers (E-MIPS) as sensing elements for the detection of dengue infection

Cited by 18 publications

References 46 publications

Molecularly Imprinted Polymer-Based Electrochemical Sensors for the Diagnosis of Infectious Diseases

Molecularly Imprinted Polymer-Based Electrochemical Sensors for the Diagnosis of Infectious Diseases

Targeted Cell Labeling and Sorting of Prokaryotes for Cultivation and Omics Approaches

Research progress and perspectives in field‐induced imprinted polymers

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