Electroretinographic abnormalities associated with pregabalin: a case report

Ninomiya, Wakana; Mizobuchi, Kei; Hayashi, Takaaki; Okude, Sachiyo; Katagiri, Satoshi; Kubo, Akiko; Masuhara, Nami; Nakano, Tadashi

doi:10.1007/s10633-019-09743-1

Cited by 17 publications

(5 citation statements)

References 45 publications

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“…Furthermore, ERG at 53 years of age showed within normal range in the b-waves of DA 0.01, approximately 40% and 70% of our controls [ 35 ] in the a- and b-waves of DA 3.0, approximately 50% of the controls in the a- and b- waves of LA 3.0, and approximately 70% of the controls in the b-waves of LA 3.0 flicker. 14 years later, ERG revealed reduced to 10–15% of our controls [ 36 ] in the b-waves of DA 0.01 and the a- and b-waves of DA 3.0, 20% of the controls in the a- and b-waves of LA 3.0 and the b-waves of LA3.0 flicker ( Figure 6 F).…”

Section: Resultsmentioning

confidence: 91%

“…Full-field electroretinography (ERG) was recorded in accordance with the protocols of the International Society for Clinical Electrophysiology of Vision [ 32 ] by using a built-in light-emitting diode electrode (LE-4000; Tomey, Nagoya, Japan) or a Ganzfeld dome with an EOG-ERG Ganzfeld stimulator (Electrophysiology system; LACE Elettronica). The detailed procedure and ERG conditions have been reported previously [ 33 , 34 , 35 , 36 ]. Macular function was evaluated by multifocal ERG (LE-4100, Tomey, Nagoya, Japan), as previously described [ 37 , 38 ].…”

Section: Methodsmentioning

confidence: 99%

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Genotype-Phenotype Correlations in RP1-Associated Retinal Dystrophies: A Multi-Center Cohort Study in JAPAN

Mizobuchi

Hayashi

Oishi

et al. 2021

JCM

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Background: Little is known about genotype–phenotype correlations of RP1-associated retinal dystrophies in the Japanese population. We aimed to investigate the genetic spectrum of RP1 variants and provide a detailed description of the clinical findings in Japanese patients. Methods: In total, 607 patients with inherited retinal diseases were examined using whole-exome/whole-genome sequencing (WES/WGS). PCR-based screening for an Alu element insertion (c.4052_4053ins328/p.Tyr1352AlafsTer9) was performed in 18 patients with autosomal-recessive (AR)-retinitis pigmentosa (RP) or AR-cone dystrophy (COD)/cone-rod dystrophy (CORD), including seven patients with heterozygous RP1 variants identified by WES/WGS analysis, and 11 early onset AR-RP patients, in whom no pathogenic variant was identified. We clinically examined 25 patients (23 families) with pathogenic RP1 variants, including five patients (five families) with autosomal-dominant (AD)-RP, 13 patients (11 families) with AR-RP, and seven patients (seven families) with AR-COD/CORD. Results: We identified 18 pathogenic RP1 variants, including seven novel variants. Interestingly, the Alu element insertion was the most frequent variant (32.0%, 16/50 alleles). The clinical findings revealed that the age at onset and disease progression occurred significantly earlier and faster in AR-RP patients compared to AD-RP or AR-COD/CORD patients. Conclusions: Our results suggest a genotype–phenotype correlation between variant types/locations and phenotypes (AD-RP, AR-RP, and AR-COD/CORD), and the Alu element insertion was the most major variant in Japanese patients with RP1-associated retinal dystrophies.

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Section: Resultsmentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Genotype-Phenotype Correlations in RP1-Associated Retinal Dystrophies: A Multi-Center Cohort Study in JAPAN

Mizobuchi

Hayashi

Oishi

et al. 2021

JCM

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“…Ninomiya et al mentioned the retinal dysfunction effect of pregabalin. They showed that 10 months of pregabalin use can cause erroneous synaptic transfer from rod/cone photoreceptors to bipolar cells in the patient [27]. In addition, retinal teratogenicity of pregabalin in the chick embryo model was investigated by Seçinti, and it was reported that the use of pregabalin during pregnancy may be teratogenic due to damage to the retinal layers [28].…”

Section: Discussionmentioning

confidence: 99%

Can the long term using of pregabalin in fibromyalgia affect the choroid and retinal nerve fiber layer?

Biçer

Zor

Biçer

et al. 2021

Eye

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BACKGROUND: In this study, the effects of long-term pregabalin use on the choroid and retinal nerve fiber layer were investigated in the fibromyalgia disease. METHODS: The patient group consisted of 41 fibromyalgia patients using pregabalin. The control group consisted of 41 newly diagnosed fibromyalgia patients who had not received any treatment yet. Choroidal and retinal nerve fiber layer thickness measurements were performed with Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA, USA) 30 minutes after pupil dilation with 1% tropicamide. RESULTS: There was no difference in subfoveal choroidal thickness, nasal choroidal thickness and temporal choroidal thickness between the patient and control groups (p > 0.05). Increasing the duration of drug use within the patient group was found to thin the retinal nerve fiber layer (p < 0.05). CONCLUSION: We found that pregabalin had no effect on the choroid, while it had a thinning effect for retinal nerve fiber layer. It is recommended not to be preferred pregabalin in fibromyalgia patients with retinal nerve fiber layer damage such as diabetic retinopathy and glaucoma. Patients treated with pregabalin should have regular control in the ophthalmology clinic.

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“…Full-field electroretinography using a light-emitting diode built-in electrode (LE-4000, TOMEY Corp., Nagoya, Japan) was performed in accordance with the protocols of the International Society for Clinical Electrophysiology of Vision [9], except for a light intensity of 200 cd s/ m 2 (DA 200) instead of DA 10.0 for bright (or strong)flash electroretinography. The procedure and conditions have been previously reported [10][11][12][13]. This ERG system was approved by the Ministry of Health, Labor and Welfare of Japan on September 30, 2002 (approval number: 222AGBZX00211000).…”

Section: Case Presentationmentioning

confidence: 99%

“…This ERG system was approved by the Ministry of Health, Labor and Welfare of Japan on September 30, 2002 (approval number: 222AGBZX00211000). All electroretinography responses of the patient were compared with those of previously reported controls (n = 23) [12] b Eleven days after presentation: improvement in the ellipsoid zone findings can be observed. c One month after presentation: preservation of the improved ellipsoid zone can be observed Fig.…”

Section: Case Presentationmentioning

confidence: 99%

Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report

et al. 2021

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Purpose The purpose of this report was to describe the case of a 68-year-old male patient with stage IV colon cancer who exhibited electroretinographic abnormalities that are similar to those of KCNV2 retinopathy. Methods The patient presenting with photophobia, reduced visual acuity, and poor general conditions, the onset of which occurred ten days before presentation, was examined using fundoscopy, full-field electroretinography, blood tests, and abdominal computed tomography. Results The patient’s decimal best-corrected visual acuity (BCVA) was 0.4 in each eye. Fundoscopy showed bull's eye-like maculopathy in both eyes. Electroretinographic findings were similar to the characteristic findings of KCNV2 retinopathy: Rod electroretinogram showed delayed and preserved b-wave amplitudes; bright-flash electroretinogram showed double troughs of a-waves; b/a ratios shown by bright-flash electroretinogram were higher than those shown by standard-flash electroretinogram; and both cone and 30-Hz flicker electroretinograms showed extinguished responses. His serum potassium level increased to 6.2 mmol/L (normal range 3.6–4.8 mmol/L) owing to hydronephrosis resulting from disseminated carcinoma. After performing an emergency surgery to treat this condition, the serum potassium level immediately decreased to a normal range. Eleven days after presentation, rod and standard/bright-flash electroretinography showed improvement in the implicit time of the rod b-waves and the a-waves. Unexpectedly, the responses recorded by cone and 30-Hz flicker electroretinography became normal. The symptoms and maculopathy disappeared, and his BCVA improved to 1.2. Conclusions The abnormal electroretinographic findings might be associated with the transient increase in serum potassium level.

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Electroretinographic abnormalities associated with pregabalin: a case report

Cited by 17 publications

References 45 publications

Genotype-Phenotype Correlations in RP1-Associated Retinal Dystrophies: A Multi-Center Cohort Study in JAPAN

Genotype-Phenotype Correlations in RP1-Associated Retinal Dystrophies: A Multi-Center Cohort Study in JAPAN

Can the long term using of pregabalin in fibromyalgia affect the choroid and retinal nerve fiber layer?

Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report

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