Electrospinning Nanofibers for Therapeutics Delivery

Abstract

The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for nanofiber fabrication, along with the release of therapeutic payload in sustained and controlled release patterns, make nanofibers an ideal material for drug delivery research. Electrospinning is the conventional method for fabricating nanofibers with different morphologies and is often used for the mass production of nanofibers. This review highlights the recent advancements in the use of nanofibers for the delivery of therapeutic drugs, nucleic acids and growth factors. A detailed mechanism for fabricating different types of nanofiber produced from electrospinning, and factors influencing nanofiber generation, are discussed. The insights from this review can provide a thorough understanding of the precise selection of materials used for fabricating nanofibers for specific therapeutic applications and also the importance of nanofibers for drug delivery applications.

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

“…The electrosprayed mat eliminated P. aeruginosa bacterial colonies within three days of daily dressing changes in an in vivo full-thickness excisional wound treated initially by debridement [110]. These recent studies suggest excellent wound treatment using nanofibers; however, their use in clinical practice is limited due to toxicity, large-scale production, and ability to control capacity and functionality [206].…”

An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

“…Moreover, the authors reported that viability can be correlated with the hydrophobicity and to the extreme length of lactic acid bacteria, whereas a horizontal or vertical electrospinning set-up did not have any role. Development of nanofibers via electrospinning has a great potential and use in pharmaceutical and food industry for their properties i.e., sterile nature, biocompatibility, adhesiveness, efficiency, and as vehicle for controlled and sustained release in drug delivery [179][180][181][182]. Electrospinning and electrospraying represent innovative technologies for the delivery of nutraceuticals [183].…”

How innovative drug delivery devices can help realize clinical utility of new effective therapies

“…The majority of delivery routes investigated over the years to provide the administration of drug molecules by electrospun systems, including oral, buccal, etc. For example, macro-and micromolecules captured in nanofibers as film-based DDS were delivered by oral route, and electrospun scaffolds have delivered proteins or vaccines by buccal or sublingual route and has also been used to prepare electrospun scaffolds as ocular inserts to treat inflammation or infections [11]. Moreover, the technique has been used to integrate a number of key drugs, such as ampicillin, cefoxitin, tetracycline, and triclosan into FDA-approved polymers (natural or synthetic).…”