Electrospray ionization–tandem mass spectrometric study of fused nitrogen‐containing ring systems

Abstract

Four fused nitrogen-containing ring systems were investigated by electrospray ionization-tandem mass spectrometry: Pyridazino-indoles, pyridazino-quinolines, a pyrimido-quinoline derivative and pyrimido-cinnolines. Fragmentation patterns of these compounds are discussed and compared. Several characteristic cross-ring fragments were formed mainly on the pyridazine and pyrimidine rings of the ring systems. The connected Cl, NO 2 , Me, Ph and more extended heterocyclic substituents influenced the fragmentation.

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“…A mass spectrometer consists of an ion source for sample ionization, a mass analyzer for mass separation and a detector for ion detection. There are several types of mass analyzers available, which separate ionized masses based on mass-to-charge ratio (m/z) which can be detected by the detector: quadrupole (ion trap), time-of-flight (TOF), magnetic or electrostatic double sector, and ion cyclotron resonance mass analyzers [175][176][177] . Which mass analyzer to use is dependent on the application.…”