Electrospray technology as a probe for cocrystal synthesis: Influence of solvent and coformer structure

Patil, Sharvil; Ujalambkar, Vinayak; Mahadik, Abhijeet

doi:10.1016/j.jddst.2017.04.001

Cited by 23 publications

(16 citation statements)

References 36 publications

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“…The solution jet is dried, and the generated particles are collected on a charged powder collector. Patil et al demonstrated the potential of this process to generate cocrystals of carbamazepine and itraconazole with different coformers …”

Section: Cocrystal Productionmentioning

confidence: 99%

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Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications

Karimi-Jafari

Padrela

Walker

et al. 2018

Crystal Growth & Design

485

431

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Originally discovered almost a century ago, cocrystals continue to gain interest in the modern day due to their ability to modify the physical properties of solid-state materials, particularly pharmaceuticals. Intensification of cocrystal research efforts has been accompanied by an expansion of the potential applications where cocrystals can offer a benefit. Where once solubility manipulation was seen as the primary driver for cocrystal formation, cocrystals have recently been shown to provide attractive options for taste masking, mechanical property improvement, and intellectual property generation and extension. Cocrystals are becoming a commercial reality with a number of cocrystal products currently on the market and more following in registration and clinical trial phases. Increased commercialization of cocrystals has in turn necessitated additional research on methods to make cocrystals, with particular emphasis placed on emerging technologies that can offer environmentally attractive and efficient options. Methods of producing cocrystals and of harnessing the bespoke physical property adjustment provided by cocrystals are reviewed in this article, with a particular focus on emerging trends in these areas.

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Section: Cocrystal Productionmentioning

confidence: 99%

“…Patil et al demonstrated the potential of this process to generate cocrystals of carbamazepine and itraconazole with different coformers. 102…”

Section: Rapid Expansion Of Supercritical Solvents the Rapid Expansio...mentioning

confidence: 99%

Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications

Karimi-Jafari

Padrela

Walker

et al. 2018

Crystal Growth & Design

485

431

View full text Add to dashboard Cite

show abstract

“…The electrospray cocrystallization of carbamazepine and itraconazole ( Patil et al, 2017 ), developed with the desired conformer, revealed that the electrospray technique is a unique technique which is a single-step, selective method for the synthesis of cocrystals, which leaves the traditional techniques far behind. This technique involves the occurrence of droplets and charging at the same time by providing an electric field, which leads to the formation of elongated solution droplets.…”

Section: Cocrystallization Techniquesmentioning

confidence: 99%

Recent Advances in Pharmaceutical Cocrystals: From Bench to Market

Bandaru¹,

Rout²,

Kenguva³

et al. 2021

Front. Pharmacol.

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The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size distribution, surface area, solubility, stability, porosity, thermal properties, etc. The formation of salts, solvates, and polymorphs are the conventional strategies for altering the solid characteristics of pharmaceutical compounds, but they have their own limitations. Cocrystallization approach was established as an alternative method for tuning the solubility, permeability, and processability of APIs by introducing another compatible molecule/s into the crystal structure without affecting its therapeutic efficacy to successfully develop the formulation with the desired pharmacokinetic profile. In the present review, we have grossly focused on cocrystallization, particularly at different stages of development, from design to production. Furthermore, we have also discussed regulatory guidelines for pharmaceutical industries and challenges associated with the design, development and production of pharmaceutical cocrystals with commercially available cocrystal-based products.

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“…Nanocrystals of carbamazepine (Figure 10C) were obtained by electrospray and the authors correlated the variables (drug concentration, conductivity, flow rate, voltage, and current) to the crystal sizes that fell within the range 320-1756 nm, depending on the experimental setup [219]. Electrospray is also employed in the production of co-crystals, as reported by Patil et al However no specification on the size of the crystal is provided [220,221].…”

Section: Challenges For Scale-up Productionmentioning

confidence: 97%

Production of pure drug nanocrystals and nano co-crystals by confinement methods

Fontana

Figueiredo

Zhang

et al. 2018

Advanced Drug Delivery Reviews

138

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The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water-soluble drug compounds synthetized and due to the advantages brought by the nanonization process. The downsizing processes are done using a top-down approach (milling and homogenization currently employed at the industrial level), while the crystallization process is performed by bottom-up techniques (e.g., antisolvent precipitation, use of supercritical fluids or spray and freeze drying). In addition, the production of nanocrystals in confined environment can be achieved within microfluidics channels. This review analyzes the processes for the preparation of nanocrystals and co-crystals, divided by top-down and bottom-up approaches, together with their combinations. The combination of both strategies merges the favorable features of each process and avoids the disadvantages of single processes. Overall, the applicability of drug nanocrystals is highlighted by the widespread research on the production processes at the engineering, pharmaceutical, and nanotechnology level.

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Electrospray technology as a probe for cocrystal synthesis: Influence of solvent and coformer structure

Cited by 23 publications

References 36 publications

Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications

Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications

Recent Advances in Pharmaceutical Cocrystals: From Bench to Market

Production of pure drug nanocrystals and nano co-crystals by confinement methods

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