Electrosprayed cysteine-functionalized degradable amphiphilic block copolymer microparticles for low pH-triggered drug delivery

Abstract

Fluorescent dye encapsulation and release using mucoadhesive degradable thiol-functionalized amphiphilic block copolymer microparticles prepared by electrospraying.

The block copolymer shuffle in size exclusion chromatography: the intrinsic problem with using elugrams to determine chain extension success

“…2. Although the retention time consistently decreases with increasing PEG length, an initial increase is observed upon converting the OHPV homopolymer (entry 1) into OHPV-b-(PEG) 12 . In other words, the (apparent) hydrodynamic volume of the BCP is smaller than that of the precursor.…”

“…It is particularly worthwhile reviewing such "inhomogeneous" BCPs since their internally cooperative-or multifunctionality is of strong interest for advanced applications, as smart coatings, [6][7][8][9] drug delivery, [10][11][12][13] bioimaging, [14][15][16] optoelectronics [17][18][19][20] and energy harvesting and storage. [21][22][23][24][25] We subdivide these non-classical BCPs into four "behavioural categories" and conclude with a brief survey of methods to improve the accuracy of molecular weight estimates.…”

End‐/side‐chain fluorescent polymer conjugates: Stimuli‐responsiveness and biological applications

“…Side-chain FITC-tagged poly(L-lactide)b-poly(2-(methacryloyloxy)ethyl phosphorylcholine)-st-(methacrylic acid N-hydroxysuccinimide ester) Fl-(PLA-b-P(MPC-st-NHSMA)) (Fl-Poly19, Scheme 5A) was also synthesized through multi-step reactions. 159 In this process, a hydroxyl functionalized dithiocarbonylthio compound was used as initiator as well as a RAFT agent. First, ROP of LA was conducted using this initiator and DMAP catalyst to synthesize PLA-based macro-RAFT for the copolymerization of MPC and NHSMA monomers.…”

“…The L-cysteine functionalization of this copolymer at its NHS moiety followed by the attachment of FITC through the NCS and SH coupling, produced the final fluorescent Fl-Poly19 conjugate. 159 In a recent report, Isely et al 160 employed the coupling reaction of OH groups of PVA with the N C S group of FITC for producing fluorescent Fl-poly(vinyl alcohol) conjugate (Fl-Poly20, Scheme 5A). More recently, Xu et al 161 Scheme 5A) by sequential RAFT polymerization and click reaction.…”

“…Copyright, American Chemical Society. The structures of Fl‐Poly19 , 159 Rh‐Poly14 , 162 and Rh‐Poly15 , 163 were adapted from published papers. Copyright, Royal Society of Chemistry.…”