Electrosprayed microparticles: a novel drug delivery method

Çam, Muhammet Emin; Zhang, Yue; Edirisinghe, Mohan

doi:10.1080/17425247.2019.1648427

Cited by 21 publications

(20 citation statements)

References 15 publications

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“…If this coulomb force is large enough to overcome the surface tension force, the drop detaches and breaks up into submicron droplets which quickly solidify into self-dispersing nano and micro capsules with limited agglomeration and Natural Polymers in Micro-and Nanoencapsulation for Therapeutic and Diagnostic… DOI: http://dx.doi.org/10.5772/intechopen.94856 coagulation. The technique just like its better applied counterpart, electrospinning, is a facile relatively inexpensive, flexible, easy-to set-up and versatile (in terms of processable materials, set up configuration) process that is amenable to continuous manufacture of tunable compositions, and customized properties of size, and morphology [53]. Droplet generation starts with pushing the liquid in the syringe to flow through the nozzle to the metallic capillary which is connected to the collector through a voltage generating unit.…”

Section: Techniques Based On Drop Generation Methodsmentioning

confidence: 99%

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Ngwuluka¹,

Abu-Thabit²,

Uwaezuoke³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

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Encapsulation, specifically microencapsulation is an old technology with increasing applications in pharmaceutical, agrochemical, environmental, food, and cosmetic spaces. In the past two decades, the advancements in the field of nanotechnology opened the door for applying the encapsulation technology at the nanoscale level. Nanoencapsulation is highly utilized in designing effective drug delivery systems (DDSs) due to the fact that delivery of the encapsulated therapeutic/diagnostic agents to various sites in the human body depends on the size of the nanoparticles. Compared to microencapsulation, nanoencapsulation has superior performance which can improve bioavailability, increase drug solubility, delay or control drug release and enhance active/passive targeting of bioactive agents to the sites of action. Encapsulation, either micro- or nanoencapsulation is employed for the conventional pharmaceuticals, biopharmaceuticals, biologics, or bioactive drugs from natural sources as well as for diagnostics such as biomarkers. The outcome of any encapsulation process depends on the technique employed and the encapsulating material. This chapter discusses in details (1) various physical, mechanical, thermal, chemical, and physicochemical encapsulation techniques, (2) types and classifications of natural polymers (polysaccharides, proteins, and lipids) as safer, biocompatible and biodegradable encapsulating materials, and (3) the recent advances in using lipids for therapeutic and diagnostic applications. Polysaccharides and proteins are covered in the second part of this chapter.

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Section: Techniques Based On Drop Generation Methodsmentioning

confidence: 99%

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Ngwuluka¹,

Abu-Thabit²,

Uwaezuoke³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

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“…While the former arrangement is achieved by the spraying of a drug-polymer mixture (similarly to the electrospinning of a dispersion/emulsion), core-shell particles are mostly prepared with a special core-shell emitter. Such emitter consists of an inner capillary surrounded by a wider channel, which independently supplies the drug and polymer solutions, respectively [160,171,172]. Interesting synthesis of biodegradable triple-layered electrosprayed capsules (Fig.…”

Section: Encapsulation Methodsmentioning

confidence: 99%

“…Dried polymer molecules merge within the aerosol plume into globular structures and form nanoparticles. Due to the simplicity of this procedure and its ability to process a wide range of polymers, it is often employed in the field of microelectronics [153], sensing [154], food processing [66,[155][156][157], and, especially in recent years, biomedical applications [158][159][160].…”

Section: Electrospraying Of Polymersmentioning

confidence: 99%

Electrospray: More than just an ionization source

et al. 2020

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is a potential-driven process of liquid atomization, which is employed in the field of analytical chemistry, particularly as an ionization technique for mass spectrometric analyses of biomolecules. In this review, we demonstrate the extraordinary versatility of the electrospray by overviewing the specifics and advanced applications of ESbased processing of low molecular mass compounds, biomolecules, polymers, nanoparticles, and cells. Thus, under suitable experimental conditions, ES can be used as a powerful tool for highly controlled deposition of homogeneous films or various patterns, which may sometimes even be organized into 3D structures. We also emphasize its capacity to produce composite materials including encapsulation systems and polymeric fibers. Further, we present several other, less common ES-based applications. This review provides an insight into the remarkable potential of ES, which can be very useful in the designing of innovative and unique strategies.

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“…Because of Coulombic repulsion, particle aggregation can be avoided due to self-dispersal. 37 The objective of this study is to systematically investigate the effects of PLGA polymer composition and electrosprayed nanoparticle configurations on the resulting progesterone drug release behavior in vitro. Six formulations of monodisperse nanoparticles of varying particle configurations (eg mono or core-shell, pure drug encapsulation or encapsulating drug dispersed in polymer matrix) and PLGA copolymer compositions in term of lactide: glycolide (LA:GA) ratio (75:25 or 50:50) were fabricated and tested to determine their influence on drug release behavior.…”

Section: Introductionmentioning

confidence: 99%

<p>Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations</p>

Zhang¹,

Zhang²,

Illangakoon³

et al. 2020

IJN

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Hypothesis: Developing oral formulations to enable effective release of poorly watersoluble drugs like progesterone is a major challenge in pharmaceutics. Coaxial electrospray can generate drug-loaded nanoparticles of strategic compositions and configurations to enhance physiological dissolution and bioavailability of poorly water-soluble drug progesterone. Experiments: Six formulations comprising nanoparticles encapsulating progesterone in different poly(lactide-co-glycolide) (PLGA) matrix configurations and compositions were fabricated and characterized in terms of morphology, molecular crystallinity, drug encapsulation efficiency and release behavior. Findings: A protocol of fabrication conditions to achieve 100% drug encapsulation efficiency in nanoparticles was developed. Scanning electron microscopy shows smooth and spherical morphology of 472.1±54.8 to 588.0±92.1 nm in diameter. Multiphoton Airyscan superresolution confocal microscopy revealed core-shell nanoparticle configuration. Fourier transform infrared spectroscopy confirmed presence of PLGA and progesterone in all formulations. Diffractometry indicated amorphous state of the encapsulated drug. UV-vis spectroscopy showed drug release increased with hydrophilic copolymer glycolide ratio while core-shell formulations with progesterone co-dissolved in PLGA core exhibited enhanced release over five hours at 79.9±1.4% and 70.7±3.5% for LA:GA 50:50 and 75:25 in comparison with pure progesterone without polymer matrix in the core at 67.0±1.7% and 57.5±2.8%, respectively. Computational modeling showed good agreement with the experimental drug release behavior in vitro.

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Electrosprayed microparticles: a novel drug delivery method

Cited by 21 publications

References 15 publications

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Electrospray: More than just an ionization source

<p>Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations</p>

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