Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1

Kibler, Elina; Lavrinenko, Anastasia K.; Kolesnik, Ilya; Stankevich, Ksenia S.; Bolbasov, E. N.; Kudryavtseva, Valeriya; Leonov, Andrey; Schepetkin, Igor A.; Khlebnikov, Аndrei I.; Quinn, Mark T.; Tverdokhlebov, Sergei I.

doi:10.1016/j.eurpolymj.2020.109598

Cited by 9 publications

(2 citation statements)

References 66 publications

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“…Our group is involved in the research of polycyclic N-containing ligandsoximes of 11 H -indeno[1,2- b ]quinoxalin-11-one and its structural analogues . 11 H -Indeno[1,2- b ]quinoxalin-11-one oxime, often denoted in the literature as IQ1, and its sodium salt, IQ1S, were reported as potent c-Jun N-terminal kinase (JNK3) inhibitors, , anti-inflammatory agents, − neuroprotectors, , and antitumor agents. − Tryptanthrin demonstrates a wide range of bioactivities, , including antibacterial, , antiviral, anticancer, , and anti-inflammatory activity. However, the coordination chemistry of such compounds is insufficiently explored.…”

Section: Introductionmentioning

confidence: 99%

Arene–Ruthenium(II) Complexes Containing 11H-Indeno[1,2-b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones

et al. 2020

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A series of novel mono- and binuclear arene–ruthenium(II) complexes [(p-cym)Ru(L)Cl] containing 11H-indeno[1,2-b]quinoxalin-11-one derivatives or tryptanthrin-6-oxime were synthesized and characterized by X-ray crystallography, IR, NMR spectroscopy, cyclic voltammetry, and elemental analysis. Theoretical calculations invoking singlet state geometry optimization, solvation effects, and noncovalent interactions were done using density functional theory (DFT). DFT calculations were also applied to evaluate the electronic properties, and time-dependent DFT was applied to clarify experimental UV–vis results. Cytotoxicity for cancerous and noncancerous human cell lines was evaluated with cell viability MTT assay. Complexes demonstrated a moderate cytotoxic effect toward cancerous human cell line PANC-1. The catalytic activity of the complexes was evaluated in transfer hydrogenation of aryl ketones. All complexes exhibited good catalytic activity and functional group tolerance.

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Section: Introductionmentioning

confidence: 99%

Arene–Ruthenium(II) Complexes Containing 11H-Indeno[1,2-b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones

et al. 2020

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“…The VF of the drug in rectangular and small pyramid microcapsules is roughly estimated to be 48.30% and 77.32%, respectively, which is much higher than that of typical microspheres used as an injectable drug depot system. − The theoretical (maximum) VF of the drug in rectangular and pyramid microcapsules is estimated to be 87.90% and 88.05%, respectively, which means that the volume of cargo with smaller precipitates could take more than 80% of the capsule.…”

Section: Resultsmentioning

confidence: 99%

Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery

Kudryavtseva

Boi

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et al. 2021

ACS Appl. Mater. Interfaces

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This work describes the preparation and characterization of printed biodegradable polymer (polylactic acid) capsules made in two different shapes: pyramid and rectangular capsules about 1 and 11 μm in size. Obtained core−shell capsules are described in terms of their morphology, loading efficiency, cargo release profile, cell cytotoxicity, and cell uptake. Both types of capsules showed monodisperse size and shape distribution and were found to provide sufficient stability to encapsulate small watersoluble molecules and to retain them for several days and ability for intracellular delivery. Capsules of 1 μm size can be internalized by HeLa cells without causing any toxicity effect. Printed capsules show unique characteristics compared with other drug delivery systems such as a wide range of possible cargoes, triggered release mechanism, and highly controllable shape and size.

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Electrospray particles as drug delivery systems

Thakkar

Misra

2021

Biomedical Applications of Electrospinning and Electrospraying

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Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1

Cited by 9 publications

References 66 publications

Arene–Ruthenium(II) Complexes Containing 11H-Indeno[1,2-b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones

Arene–Ruthenium(II) Complexes Containing 11H-Indeno[1,2-b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones

Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery

Electrospray particles as drug delivery systems

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