Electrospun Composite Nanofibrous Materials Based on (Poly)-Phenol-Polysaccharide Formulations for Potential Wound Treatment

Abstract

In this paper, we focus on the preparation of electrospun composite nanofibrous materials based on (poly)-phenol-polysaccharide formulation. The prepared composite nanofibres are ideally suited as a controlled drug delivery system, especially for local treatment of different wounds, owing to their high surface and volume porosity and small fibre diameter. To evaluate the formulations, catechin and resveratrol were used as antioxidants. Both substances were embedded into chitosan particles, and further subjected to electrospinning. Formulations were characterized by determination of the particle size, encapsulation efficiency, as well as antioxidant and antimicrobial properties. The electrospinning process was optimised through fine-tuning of the electrospinning solution and the electrospinning parameters. Scanning electron microscopy was used to evaluate the (nano)fibrous structure, while the successful incorporation of bio substances was assessed by X-ray Photoelectron Spectroscopy and Fourier transform infrared spectroscopy. The bioactive properties of the formed nanofibre -mats were evaluated by measuring the antioxidative efficiency and antimicrobial properties, followed by in vitro substance release tests. The prepared materials are bioactive, have antimicrobial and antioxidative properties and at the same time allow the release of the incorporated substances, which assures a promising use in medical applications, especially in wound care.

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

“…These particles were embedded in poly(ethylene oxide) (PEO) nanofibers and challenged against S. aureus and E. coli. The reported reduction of bacteria was over 83 and 99% for S. aureus and E. coli, respectively [141].…”

Cellulose–Chitosan Functional Biocomposites

“…Chitosan nanofibres also improved the absorbency of cotton gauzes by more than 50%, which likely improved the absorption of blood and wound exudates. In a study by our group [ 163 ], chitosan particles with embedded catechin and with entrapped resveratrol were mixed with polyethylene oxide and used in an electrospinning device to produce nanofibres/nanocoatings that were applied to the viscose matrix material. The fabricated nanofibre composites deposited on viscose material exhibited excellent antimicrobial and antioxidant activity.…”

Polysaccharide Electrospun Nanofibers for Wound Healing Applications

“…Antibiotics have a good antibacterial effect, but the widespread use of antibiotics leads to bacterial resistance. 126 , 127 Unlike traditional antibiotics, metal nanoparticles do not bind to specific receptors on bacterial cells, which makes it difficult for bacteria to develop drug resistance and also expands the broad spectrum of antibacterial activity. 128 Therefore, polysaccharide electrospun fibers loaded with metal nanoparticles were used to prevent bacterial infection at the wound site.…”