Electrospun nanofibers for local anticancer therapy: Review of in vivo activity

Poláková, Lenka; Širc, Jakub; Hobzová, Radka; Cocârță, Ana-Irina; Heřmánková, Eva

doi:10.1016/j.ijpharm.2018.12.059

Cited by 50 publications

(27 citation statements)

References 67 publications

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“…However, this traditional chemotherapy method is associated with poor targetability and its highly invasive nature [37], leading to adverse side effects such as undesirable reactions and multidrug resistance [38]. Thus, the local application of chemotherapeutics, with higher drug concentration at the tumor site and less effect to normal tissues, would be beneficial for solid tumors [4].…”

Section: Tumor Microenvironment and Local Anti-tumor Treatmentmentioning

confidence: 99%

“…Despite advances in surgical techniques, post-surgical local tumor recurrence and metastasis may still occur [3], which hence requires the development of effective treatments to eliminate residual tumor cells. Meanwhile, there are some malignant tumors that are possibly locally infiltrated, and cannot be readily resected surgically, for which new treatment methods are demanded [4]. Currently, chemotherapy is the most common method for these conditions due to its high therapeutic efficacy, yet it is often accompanied with complications and side effects [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Functional Electrospun Fibers for Local Therapy of Cancer

2020

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Despite great efforts and advancement in the treatment of cancer, tumor recurrence and metastasis remain significant challenges and demand novel therapy strategies. Recently, advances in biomaterials and drug delivery systems have facilitated the development of the local therapy of cancer, among which electrospun nanofibrous scaffolds show great promise owing to their porous structure, relatively large surface area, high drug loading capacity, similarity with the native extracellular matrix, and possibility of the combination of various therapies. Here, we review this rapidly developing field of electrospun nanofibrous scaffolds as a drug delivery system for cancer local therapy, in particular addressing stimuli-responsive drug release, as well as its combination with stem cell and immune therapy. Challenges and future perspectives are also discussed.

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Section: Tumor Microenvironment and Local Anti-tumor Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional Electrospun Fibers for Local Therapy of Cancer

2020

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“…11 A variety of drugs including antibiotics, 12 proteins, 13 DNA, RNA, growth factors 14 and anticancer drugs have been loaded into electrospun nanobers for disease treatment. [15][16][17] In recent years, many kinds of enzyme have also been successfully immobilized in bers by electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

et al. 2019

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“…The body of work in the literature to date thus suggests that electrospun nanofibers have considerable potential for use in cancer treatment [19]. However, no studies to date have probed the combination of PDT with chemotherapy via electrospun formulations.…”

Section: Introductionmentioning

confidence: 99%

Electrospun oral formulations for combined photo-chemotherapy of colon cancer

Sanchez-Vazquez

Trindade

et al. 2019

Colloids and Surfaces B: Biointerfaces

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In this work, we report new formulations for the combined photo-chemotherapy of colon cancer. Fibers were fabricated via coaxial-electrospinning with the intent of targeting delivery of the anti-cancer drug carmofur (CAR) and the photosensitizer rose bengal (RB) selectively to the colon site. The fibers comprised a hydroxypropyl methylcellulose (HPMC) core loaded with the active ingredients, and a pH-sensitive Eudragit L100-55 shell. The fibers were found to be homogeneous and cylindrical and have visible core-shell structures. X-ray diffraction and differential scanning calorimetry demonstrated that both CAR and RB were present in the fibers in the amorphous physical form. In vitro drug release studies showed that the fibers have the potential to selectively deliver drugs to the colon, with only 10-15 % release noted in the acidic conditions of the stomach but sustained release at pH 7.4. Cytotoxicity studies were undertaken on human dermal fibroblast (HDF) and colon cancer (Caco-2) cells, and the influence of light on cell death was also explored. The fibers loaded with CAR alone showed obvious toxicity to both cell lines, with and without the application of light. The RB-loaded fibers led to high viability (ca. 80 % for both cell types) in the absence of light, but much greater toxicity was noted (30-60 %) with light. The same trends were observed with the formulation containing both CAR and RB, but with lower viabilities. The RB and RB/CAR loaded systems show clear selectivity for cancerous over non-cancerous cells. Finally, mucoadhesion studies revealed there were strong adhesive forces between the rat colonic mucosa and the fibers after they had passed through an acidic environment. Such electrospun fibers thus could have potential in the development of oral therapies for colon 2 cancer.

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Electrospun nanofibers for local anticancer therapy: Review of in vivo activity

Cited by 50 publications

References 67 publications

Functional Electrospun Fibers for Local Therapy of Cancer

Functional Electrospun Fibers for Local Therapy of Cancer

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

Electrospun oral formulations for combined photo-chemotherapy of colon cancer

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