Electrospun Nanofibers in Tissue Engineering

Ladd, Mitchell R.; Hill, Tanner K.; Yoo, James J.; Lee, Sang Jin

doi:10.5772/24095

Cited by 7 publications

(2 citation statements)

References 64 publications

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“…Over the past decades, many developments have focused on fabricating ECM-like scaffolds made of nanofibers through electrospinning because of their unique morphology, high surface-area-to-volume ratio, and porosity [ 95 , 96 ]. ES-fabricated biostructures provide good assistance for various tissue types regarding regeneration and reconstruction, namely, they are able to mimic the natural ECM and initiate special biological responses, accelerating the attachment and stimulating cell growth, proliferation, and differentiation [ 24 , 97 ].…”

Section: Resultsmentioning

confidence: 99%

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Stoica

Albuleț

Bîrcă

et al. 2023

IJMS

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Injuries and diseases of the skin require accurate treatment using nontoxic and noninvasive biomaterials, which aim to mimic the natural structures of the body. There is a strong need to develop biodevices capable of accommodating nutrients and bioactive molecules and generating the process of vascularization. Electrospinning is a robust technique, as it can form fibrous structures for tissue engineering and wound dressings. The best way of forming such meshes for wound healing is to choose two polymers that complement each other regarding their properties. On the one hand, PVA is a water-soluble synthetic polymer widely used for the preparation of hydrogels in the field of biomedicine owing to its biocompatibility, water solubility, nontoxicity, and considerable mechanical properties. PVA is easy to subject to electrospinning and can offer strong mechanical stability of the mesh, but it is necessary to improve its biological properties. On the other hand, CS has good biological properties, including biodegradability, nontoxicity, biocompatibility, and antimicrobial properties. Still, it is harder to electrospin and does not possess as good mechanical properties as PVA. As these structures also allow the incorporation of bioactive agents due to their high surface-area-to-volume ratio, the interesting point was to incorporate usnic acid into the structure as it is a natural and suitable alternative agent for burn wounds treatment which avoids an improper or overuse of antibiotics and other invasive biomolecules. Thus, we report the fabrication of an electrospun nanofibrous mesh based on PVA, chitosan, and usnic acid with applications in wound healing. The obtained nanofibers mesh was physicochemically characterized by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). In vitro biological assays were performed to evaluate the antimicrobial properties of the samples using the MIC (minimum inhibitory concentration) assay and evaluating the influence of fabricated meshes on the Staphylococcus aureus biofilm development, as well as their biocompatibility (demonstrated by fluorescence microscopy results, an XTT assay, and a glutathione (GSH) assay).

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Section: Resultsmentioning

confidence: 99%

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Stoica

Albuleț

Bîrcă

et al. 2023

IJMS

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“…These parameters are redivided into three significant categories: solution parameters, processing parameters, and ambient parameters ( Table 2 ). 23 However, we do not want to discuss the electrospinning process. Up to date, electrospun nanofibers are produced using more than 100 various polymers through synthesizing and organic products.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application

et al. 2021

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Unique mechanical properties, miscibility potency, and biodegradability are the three prominent features of Polycaprolactone (PCL), making it an attractive biomaterial which commonly applied in regenerative medicine and biomedical engineering. Different strategies developed for fabricating nanofibrous construct, electrospinning is a practical, simple, and efficient technique based on electro-hydrodynamic systems that use an electrified viscous fluid jet drawn by the air toward a collector at a changing electric potential. PCL electrospun-based nanofibrous composites as proper scaffolds are employed in stem cell-related research, particularly in tissue engineering, wound dressing, and systems designed for sending drugs. A compilation of mechanochemical properties and most common biological performance on PCL-based electrospun fibrous structures in biomedical application are included in this study. Therefore, electrospun PCL nanofiber applying has been presented, and after that, current progress and prospects have been discussed. Literature reviews revealed that electrospun PCL nanofibrous composites had gained significant attention in regenerative medicine, and these structures have shown notable development in mechanobiological properties. This evidence is a crucial success for biomedical strategies, especially in regenerative medicine.

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Bionanofibers in drug delivery * *Xin Zhao and Lara Yildirimer contributed equally.

Zhao

Yildirimer

Lin

et al. 2016

Nanobiomaterials in Drug Delivery

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Electrospun Nanofibers in Tissue Engineering

Cited by 7 publications

References 64 publications

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application

Bionanofibers in drug delivery * *Xin Zhao and Lara Yildirimer contributed equally.

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