Electrospun Nanofibrous Polycaprolactone Scaffolds for Tissue Engineering of Annulus Fibrosus

Koepsell, Laura; Zhang, Lifeng; Neufeld, Daniel A.; Fong, Hao; Deng, Ying

doi:10.1002/mabi.201000352

Cited by 63 publications

(46 citation statements)

References 56 publications

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“…Badylak et al, 1995;Dejardin et al, 2001;Jonsson et al, 2011;Kim et al, 2012;Kim et al, 2014b ; Ledet et al, 2009;Visage et al, 2006 Danhier et al, 2012;El-Amin et al, 2003;Endres et al, 2010;Feng et al, 2011;Kim et al, 2014a;Lai et al, 2014;Liang et al, 2013;Mizuno et al, 2004;Ruan et al, 2010 Poly-ε- Sinha et al, 2004;Silva et al, 2007;Li et al, 2005a;Lopez et al, 2010;Koepsell et al, 2011a ;Koepsell et al, 2011b;Martin et al, 2014 Martino et al, 2005). However, chitosan gels tend to be much softer and...…”

Section: Natural Solid Biomaterialsmentioning

confidence: 99%

“…PCL has currently undergone a resurgence in research for the purpose of controlled drug release (Agrawal and Ray, 2001;Dash and Konkimalla, 2012;Silva et al, 2007). PCL is interesting for regeneration of the AF because electrospun PCL fibres can mimic an AF fibre structural alignment (Koepsell et al, 2011b). It was shown that organised alignment by electrospinning induces ECM production by porcine AF cells on PCL scaffolds (Koepsell et al, 2011a).…”

Section: Poly(-ε-caprolactone)mentioning

confidence: 99%

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Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Schutgens¹,

Tryfonidou²,

Smit³

et al. 2015

eCM

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Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the number one cause of loss of quality-adjusted life years. In search of alternatives to the current less than optimal and usually highly invasive treatments, regenerative strategies are being devised, none of which has reached clinical practice as yet. Strategies include the use of stem cells, gene therapy, growth factors and biomaterial carriers. Biomaterial carriers are an important component in musculoskeletal regenerative medicine techniques. Several biomaterials, both from natural and synthetic origin, have been used for regeneration of the IVD in vitro and in vivo. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and anti-degenerative factors determine their suitability for IVD regeneration. The current review provides an overview of the biomaterials used with respect to these properties, including their drawbacks. In addition, as biomaterial application until now appears to have been based on a mix of mere availability and intuition, a more rational design is proposed for future use of biomaterials for IVD regeneration. Ideally, high-throughput screening is used to identify optimally effective materials, or alternatively medium content comparative studies should be carried out to determine an appropriate reference material for future studies on novel materials.

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Section: Natural Solid Biomaterialsmentioning

confidence: 99%

Section: Poly(-ε-caprolactone)mentioning

confidence: 99%

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Schutgens¹,

Tryfonidou²,

Smit³

et al. 2015

eCM

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“…Despite this, NP repair is likely to be insuicient, particularly in severely degenerate cases where tears in the AF may result in extrusion of the implanted biomaterial and/or cells; consequently a variety of studies have investigated biphasic scafolds which aim to repair the AF and NP simultaneously [118,125,126]. he use of electrospinning polymeric material has attracted signiicant interest in order to the replicate the highly organised native AF structure [127]. Lazebnik et al, (2011) used a biomimetic strategy by combining porcine chondrocyte cell seeded agarose gel surrounded by cell seeded electrospun polycaprolactine ibres and observed that cells were viable, well distributed and orientated themselves in the direction of the ibres [128].…”

Section: Cellular Biomaterials For Disc Degenerationmentioning

confidence: 99%

'Cell or Not to Cell' that is the Question: For Intervertebral Disc Regeneration?

Aa¹,

Sammon²

2015

SRDT

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“…The mechanical tests revealed that POM has an excellent deformability: the compressive stress, young's modulus, and tensile strength markedly increased as the polymerization time increased. There was no permanent deformation after 500 press-loading and release cycles with Poly-D-L-lactide/Bioglass [90,91] Silk [92,93] Genipin crosslinked fibrin [94] Single unit with fiber orientation Aligned alginate/chitosan [88] Polycarbonate polyurethane linked with dihydroxyl oligomer [95,96] Polycaprolactone [97,98] Poly-L-Lactide [99] Silk fibers/chondroitin sulphate [100] Collagen fibrils [101] Biphasic scaffold Poly (polycaprolactone triol malate)/DBM [102] Composite scaffold Poly-L-Lactide as AF and hyaluronic acid hydrogel as NP [24] Polyglycolic Acid/poly-l-lactic as AF and alginate hydrogel as NP [103] Silk scaffold as AF and silicon as NP or hyaluronic acid as NP [104,105] 30 % maximum strain. When implanted into mice back subcutaneous pocket, there were no inflammation responses were found [89].…”

Section: Single Unit Without Fiber Orientationmentioning

confidence: 99%

“…Other electrospun nanofibrous scaffolds such as polycaprolactone were fabricated in random, aligned, and round-end configurations [97]. A modified electrospinning technique was utilized to generate aligned nanofibrous polymer scaffolds for engineering the basic functional unit of the AF, a single lamella [98].…”

Section: Single Unit With Oriented Fibermentioning

confidence: 99%

The challenge and advancement of annulus fibrosus tissue engineering

Jin

Shimmer

2013

Eur Spine J

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Background Intervertebral disc degeneration, a main cause of back pain, is an endemic problem and a big economic burden for the health care system. Current treatments are symptom relieving but do not address underlying problems-biological and structural deterioration of the disc. Tissue engineering is an emerging approach for the treatment of intervertebral disc degeneration since it restores the functionality of native tissues. Although numerous studies have focused on the nucleus pulposus tissue engineering and achieved successes in laboratory settings, disc tissue engineering without annulus fibrosus for the end stage of disc degeneration is deemed to fail. The purpose of this article is to review the advancement of annulus fibrosus tissue engineering. Material and Methods Relevant articles regarding annulus fibrosus tissue engineering were identified in PubMed and Medline databases. Results The ideal strategy for disc regeneration is to restore the function and integrity of the disc by using biomaterials, native matrices, growth factors, and cells that producing matrices. In the past decades there are tremendous advancement in annulus fibrosus tissue engineering including cell biology, biomaterials, and whole disc replacement. The recent promising results on whole disc tissue engineering-a composite of annulus fibrosus and nucleus pulposus-make the tissue engineering approach more appealing.Conclusion Despite the promising results in disc tissue engineering, there is still much work to be done regarding the clinical application.

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Electrospun Nanofibrous Polycaprolactone Scaffolds for Tissue Engineering of Annulus Fibrosus

Cited by 63 publications

References 56 publications

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

'Cell or Not to Cell' that is the Question: For Intervertebral Disc Regeneration?

The challenge and advancement of annulus fibrosus tissue engineering

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