Electrospun Nanofibrous Wound Dressings: A Review on Chitosan Composite Nanofibers as Potential Wound Dressings

Abstract

Advancements in topical wound dressings led to the development of products to protect the wound and facilitate addressing special issues in healing and non-healing wounds. Rapidly growing interest in nanofiber research is leading to the development of potential candidates for wound dressing applications. Electrospinning nanofibers have been considered one of the effective materials in the development of scaffolds for tissue engineering applications. Nanofibers mimic the extracellular matrix with their structural similarities, high surface area, and porosity, thereby enabling the effective delivery of antimicrobial agents in the wound milieu. Chitosan, an excellent biopolymer, is offering versatile applications as electrospun nanofibers due to the presence of its inherent properties like nontoxicity, biodegradability, biocompatibility, and antimicrobial nature, as well as its efficiency towards re‐epithelialization and regeneration of the granular layer of the wounds. The current review discusses the design and strategies used in the development of electrospun chitosan nanofibers, as well as the limitations of these strategies. This article provides the most recent information on the fabrication of chitosan composite nanofibrous materials and their applications for wound healing.

Preparation and Justification of Nanofibres-Loaded Mafenide Using Electrospinning Technique to Control Release

“…Electrospinning has emerged as a versatile and promising technique for fabricating nanofibers with high surface area and tuneable properties, making it an attractive method for drug delivery applications [4,5]. Incorporating antibiotics into these nanofibers makes it possible to regulate the release kinetics and achieve sustained drug delivery, which can help maintain therapeutic drug concentrations within the therapeutic window for an extended duration [6,7].…”

Isolation and Characterization of Chitosan Nanoparticles From Crab Shell Waste (Portunus Pelagicus)

“…Chitosan, the second most abundant natural polysaccharide obtained from crustacean shells, is a partially deacetylated chitin derivative and a mixture of d-glucosamine linked β- (1)(2)(3)(4) and N-acetyl-d-glucosamine [1,2]. Portunus pelagicus, a group of crustaceans that produce chitin, generally produces polymorphic α forms [3,4].…”

“…Portunus pelagicus, a group of crustaceans that produce chitin, generally produces polymorphic α forms [3,4]. Chitosan has an advantage over other polysaccharides because of the ease of making precise changes at the C-2 position due to its chemical structure [1,5]. Chitosan has been found to inhibit microbial growth in most of the studies [1,6].…”

“…Chitosan has an advantage over other polysaccharides because of the ease of making precise changes at the C-2 position due to its chemical structure [1,5]. Chitosan has been found to inhibit microbial growth in most of the studies [1,6]. Its non-toxic, readily biodegradable, and biocompatibility, as well as its antibacterial and anti-inflammatory capabilities, facilitate various applications of chitosan in areas such as pharmaceuticals, tissue engineering, textiles, food packaging, and agricultural products [1,7,8].…”

Development, Characterization, and Evaluation of the Antimicrobial Properties of Biodegradable Porous Scaffolds Loaded With Natural Vanillin

“…Chitosan is one of the most abundant natural amino polysaccharides which is derived from a deacetylated form of native chitin. They show nontoxic, biocompatible and biodegradable characteristics and serve as promising biomaterials for application in biomedical fields such as wound healing, drug delivery, gene delivery and tissue engineering [6]. Chitosan lacks the necessary mechanical strength for tissue engineering; however, this drawback can be solved by blending it with natural polymers like gelatin [7].…”