Electrospun PEG–PLA nanofibrous membrane for sustained release of hydrophilic antibiotics

Abstract

Reported in this study is the successful incorporation of a hydrophilic antibiotic drug, tetracycline hydrochloride (TCH), into electrospun PEG-PLA nanofibrous membrane without loss of its bioactivity. Degradation behavior of the copolymer was studied in vitro. Release behavior of TCH from the electrospun membrane and antimicrobial effects of the TCH-loaded membrane against Staphylococcus aureus culture were investigated. The medicated nanofibrous membrane demonstrated sustained release of TCH over 6 days and was found to be effective in inhibiting growth of S. aureus. In addition, increasing the antibiotic drug content in the electrospun membranes was found to enhance the anti-bacterial effectiveness of the medicated fiber mats. And the combination of mechanical barriers provided by the electrospun biodegradable nanofibrous membranes and their capability of local sustained delivery of antibiotics made these membranes more useful in biomedical applications, particularly as new wound dressings for ulcers caused by diabetes or other diseases, and to provide a better means of treatment for these malignant wounds and ulcers.

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis

“…35 Similar results were also reported in the literature. [41][42][43] From the previous optimization results, two optimum NF formulations were selected. The first one was composed of 20% (w/v) EL-NF loaded with 20% (w/v) KET and was coded as F1.…”

Bacterial cellulose nanowhiskers to enhance the properties of plastics and bioplastics of interest in food packaging

“…Moreover, a wide variety of materials have been incorporated into PLA and PHBV fibres in order to achieve the properties required for specific applications. Some examples include PLA and PHBV fibres for controlled release of antibiotics and drugs (Wang et al, 2012;Xu et al, 2010), PLA fibres loaded with silver nanoparticles as well as PHBV fibres containing plant polyphenols (Kim et al, 2009b) with antimicrobial properties and PLA fibres with conductive properties through the incorporation of polyaniline (PANI) (Abdul Rahman et al, 2010).…”

“…Moreover, a wide variety of materials have been incorporated into PLA fibres in order to achieve the properties required for specific applications. Some examples include PLA fibres for controlled release of antibiotics (Xu et al, 2010), PLA containing silver nanoparticles for obtaining fibres with antimicrobial properties it is very difficult to re-disperse cellulose nanocrystals after subjecting them to a freeze-drying process and it has been demonstrated that the use of BCNW in a partially hydrated state resulted in a more efficient incorporation into EVOH electrospun fibres . PLA fibres incorporating plant cellulose nanowhiskers with an aspect ratio of ca.…”

“…PLA, is a biodegradable, aliphatic polyester produced from L-and D-lactic acid, which can be derived from fermentation of corn starch . PLA fibres have already been produced by both electrospinning Torres-Giner et al, 2012;Xiang et al, 2009;Xu et al, 2010) and solution blow spinning (Medeiros et al, 2009;Oliveira et al, 2012a;Oliveira et al, 2011;Oliveira et al, 2012b) Cellulose nanocrystals are widely used as reinforcing agents in nanocomposites due to their interesting properties such as high surface area, low density, biodegradability and high mechanical strength .…”

“…Nevertheless, as a consequence of the incorporation of an additional component, the viscosity, surface tension and conductivity of solutions may be affected (Xu et al, 2010), in order to optimize the release properties of PLA fibres.…”