Electrospun poly (Ɛ-caprolactone)-eggshell membrane nanofibrous mat as a potential wound dressing material

Bello, Mohammed; Abdullah, Fatimah; Mahmood, Wan Mansor Wan; Malek, Nik Ahmad Nizam Nik; Jemon, Khairunnadwa Binti; Siddiquee, Shafiquzzaman; Chee, Tan Yong; Sathishkumar, P.

doi:10.1016/j.bej.2022.108563

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…Moreover, the ESM is porous and hydrophilic, and its surface properties can be adjusted to enhance biocompatibility. For example, the ESM microstructure has been modified by treatment with citric acid [ 58 , 59 ], decoration with carbon nanodots [ 62 ], and cross-linking with natural and synthetic polymers [ 63 , 64 , 65 ]. These structural modifications enhance its biocompatibility, and in some cases, also enhance its antibacterial activity [ 58 ].…”

Section: Criteria For the Development Of Bone Scaffoldsmentioning

confidence: 99%

“…The X-ray diffraction (XRD) pattern of the ESM depicts its amorphous structure with a broad halo between 2θ = 10°–30°. ( Figure 7 a) This halo is attributed to the organic components of the membrane [ 63 , 67 , 76 ]. The organic ESM does not display any diffraction lines for calcite, compared with the pattern of the calcitic mineral shell without the organic membrane ( Figure 7 b).…”

Section: Eggshell Membrane Structure and Compositionmentioning

confidence: 99%

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Eggshell Membrane as a Biomaterial for Bone Regeneration

et al. 2023

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The physicochemical features of the avian eggshell membrane play an essential role in the process of calcium carbonate deposition during shell mineralization, giving rise to a porous mineralized tissue with remarkable mechanical properties and biological functions. The membrane could be useful by itself or as a bi-dimensional scaffold to build future bone-regenerative materials. This review focuses on the biological, physical, and mechanical properties of the eggshell membrane that could be useful for that purpose. Due to its low cost and wide availability as a waste byproduct of the egg processing industry, repurposing the eggshell membrane for bone bio-material manufacturing fulfills the principles of a circular economy. In addition, eggshell membrane particles have has the potential to be used as bio-ink for 3D printing of tailored implantable scaffolds. Herein, a literature review was conducted to ascertain the degree to which the properties of the eggshell membrane satisfy the requirements for the development of bone scaffolds. In principle, it is biocompatible and non-cytotoxic, and induces proliferation and differentiation of different cell types. Moreover, when implanted in animal models, it elicits a mild inflammatory response and displays characteristics of stability and biodegradability. Furthermore, the eggshell membrane possesses a mechanical viscoelastic behavior comparable to other collagen-based systems. Overall, the biological, physical, and mechanical features of the eggshell membrane, which can be further tuned and improved, make this natural polymer suitable as a basic component for developing new bone graft materials.

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Section: Criteria For the Development Of Bone Scaffoldsmentioning

confidence: 99%

Section: Eggshell Membrane Structure and Compositionmentioning

confidence: 99%

Eggshell Membrane as a Biomaterial for Bone Regeneration

et al. 2023

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Electrospun PCL‐Based Materials for Health‐Care Applications: An Overview

Mokhena,

Chabalala,

Mapukata

et al. 2024

Macro Materials & Eng

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Polycaprolactone (PCL) is one of the durable polymers with potential in a plethora of healthcare applications. Its biological properties, degradability, chemical properties, and mechanical properties can further be modified to manufacture desired products for modern biomedical applications. Electrospinning of PCL offers the opportunity to design treatment materials that resemble human tissues and facilitate regeneration at the target site. The resultant materials can also be modified by loading other active functional materials to broaden their applications. Herein, the recent advances in the preparation and modification of PCL‐based materials for healthcare applications are elucidated. The challenges and future trends for its application in modern biomedical applications are also outlined.

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