Electrospun Polyurethane Nanofibers

Akduman, Çiğdem; Kumbasar, E. Perrin Akçakoca

doi:10.5772/intechopen.69937

Cited by 35 publications

(24 citation statements)

References 104 publications

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“…Textile end products, including clothing and home furnishings, are in intimate contact with consumers during every moment of their daily lives. The electrospun nanofiber-based products are expected to be patented and entered the market using nanotechnology by synergistic effects of nanodispersible fillers [ 141 ].…”

Section: Electrospun Nanofiber-applied Productsmentioning

confidence: 99%

Review on Electrospun Nanofiber-Applied Products

et al. 2021

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Electrospinning technology, which was previously known as a scientific interdisciplinary research approach, is now ready to move towards a practice-based interdisciplinary approach in a variety of fields, progressively. Electrospun nanofiber-applied products are made directly from a nonwoven fabric-based membranes prepared from polymeric liquids involving the application of sufficiently high voltages during electrospinning. Today, electrospun nanofiber-based materials are of remarkable interest across multiple fields of applications, such as in electronics, sensors, functional garments, sound proofing, filters, wound dressing and scaffolds. This article presents such a review for summarizing the current progress on the manufacturing scalability of electrospun nanofibers and the commercialization of electrospun nanofiber products by dedicated companies globally. Despite the clear potential and limitless possibilities for electrospun nanofiber applications, the uptake of electrospinning by the industry is still limited due to the challenges in the manufacturing and turning of electrospun nanofibers into physical products. The recent developments in the field of electrospinning, such as the prominent nonwoven technology, personal views and the potential path forward for the growth of commercially applied products based on electrospun nanofibers, are also highlighted.

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Section: Electrospun Nanofiber-applied Productsmentioning

confidence: 99%

Review on Electrospun Nanofiber-Applied Products

et al. 2021

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“…Mt/ M∞= KP (5) where, M t is drug concentration released at time t, M ∞ is equilibrium concentration of drug that must be released at infinite time in the release medium, Mt/M∞ is the fraction of drug in the release medium at time t, k KP is release rate constant, n is diffusional exponent indicating type of drug release mechanism. If n equals 1, the release mechanism is zero order; on the other hand, if 0.5 < n < 1, non-Fickian transport is the case.…”

Section: "Insert Figure 1" "Insert Table 1"mentioning

confidence: 99%

“…They could generally adapt for many applications such as filters, wound dressing materials, protective textiles, biosensors, biomedical devices, and tissue engineering, owing to their various structures. 5 The addition of the second component such as cellulose derivatives, polyethylene glycol (PEG), polycaprolactone, poly (vinyl alcohol) (PVA), poly (acrylic acid) (PAA) to PUs could give rise to fabrication of a new nanofiber with different morphological and physical structures for special applications. 6,7 u n c o r r e c t e d p r o o f…”

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confidence: 99%

Effect of polyvinylpyrolidone and ethyl cellulose in polyurethane electrospun nanofibers on morphology and drug release characteristics

Gençtürk¹,

Kahraman²,

Güngör³

et al. 2020

tjps

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Objectives: Polyurethanes are widely opted for composing nanofibers due to their ability of spinnability, biocompatibility, high chemical stability, good mechanical and elasticity properties. The desired release behaviours are also achieved by using combination of polyurethanes and various polymers. In the present study, we aimed to investigate effects of polyvinylpyrolidone and ethyl cellulose in polyurethane electrospun nanofibers in terms of the morphological structures and drug release characteristics. Materials and Methods: The nanofibers were prepared with the blends of polyurethane with either ethyl cellulose or polyvinylpyrolidone at different ratios by electrospinning method. The effect of polyvinylpyrolidone or ethyl cellulose on morphology and nanofiber diameter of the prepared nanofibers was examined with scanning electron microscopy. Compatibility of components used in the formulations of nanofibers was determined by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy. Donepezil hydrochloride, a water soluble compound, was selected as a model drug to examine its release characteristics from both polyurethane/polyvinylpyrolidone and polyurethane/ethyl cellulose electrospun nanofibers. In vitro drug release studies from electrospun nanofibers were performed according to method defined in the monograph as "paddle over disk method" of United State Pharmacopeia 38. Results: The electron microscopy images showed that addition of ethyl cellulose or polyvinylpyrolidone into polyurethane solutions affected generation of the nanofibers with smooth surface, non-beads in nanoscale. Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy spectra disclosed that ethyl cellulose and u n c o r r e c t e d p r o o f 2 polyvinylpyrolidone were separately incorporated to polyurethane matrix. In vitro release data indicated that presence of ethyl cellulose or polyvinylpyrolidone in polyurethane nanofibers dramatically changed release behaviour of Donepezil hydrochloride. Polyurethane/ethyl cellulose nanofibers (F4) provided a sustained drug release with Korsmeyer-Peppas drug release kinetic mechanism, in which the release rate was controlled by the diffusion of drug, while all of polyurethane/polyvinylpyrolidone nanofibers exhibited fastly drug release. Conclusion: Overall, this ability of polyurethane/ethyl cellulose (10/8) electrospun nanofibers has suggested the potential use of it as a drug carrier from which a watersoluble drug release may be in a sustained release fashion.

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“…Thereby, polyurethane based materials have been the subject of several studies aimed to design advanced materials with high performances [21][22][23]. In addition to polyurethanes, polyurethane nanofibers are also of great interests to researchers and have been investigated by numerous research groups [24,25]. By combining the properties of polyurethanes and electrospinning, there is the possibility to obtain scaffolds that can mimic the native extracellular matrix of biological tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Although literature shows a high number of studies [24][25][26][27][28][29][30], the possibility for combining the properties of the aforementioned compounds with the purpose of creating a novel or improved generation of fibrous scaffolds is still attractive. To realize this, it is important to study the interaction between the structures used to obtain the polymeric matrices, in order to prepare further new scaffolds for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Nanofibrous Hydroxypropyl Cellulose and β-Cyclodextrin Polyurethane Composite Mats

Grădinaru¹,

Barbălată-Mândru²,

Drobotă³

et al. 2020

Nanomaterials

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A series of nanofibrous composite mats based on polyurethane urea siloxane (PUUS), hydroxypropyl cellulose (HPC) and β-cyclodextrin (β-CD) was prepared using electrospinning technique. PUUS was synthesized by two steps solution polymerization procedure from polytetramethylene ether glycol (PTMEG), dimethylol propionic acid (DMPA), 4,4 -diphenylmethane diisocyanate (MDI) and 1,3-bis-(3-aminopropyl) tetramethyldisiloxane (BATD) as chain extender. Then, the composites were prepared by blending PUUS with HPC or βCD in a ratio of 9:1 (w/w), in 15% dimethylformamide (DMF). The PUUS and PUUS based composite solutions were used for preparation of nanofibrous mats. In order to identify the potential applications, different techniques were used to evaluate the chemical structure (Fourier transform infrared-attenuated total reflectance spectroscopy-FTIR-ATR), morphological structure (Scanning electron microscopy-SEM and Atomic force microscopy-AFM), surface properties (contact angle, dynamic vapors sorption-DVS), mechanical characteristics (tensile tests), thermal (differential scanning calorimetry-DSC) and some preliminary tests for biocompatibility and microbial adhesion.

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Electrospun Polyurethane Nanofibers

Cited by 35 publications

References 104 publications

Review on Electrospun Nanofiber-Applied Products

Review on Electrospun Nanofiber-Applied Products

Effect of polyvinylpyrolidone and ethyl cellulose in polyurethane electrospun nanofibers on morphology and drug release characteristics

Preparation and Evaluation of Nanofibrous Hydroxypropyl Cellulose and β-Cyclodextrin Polyurethane Composite Mats

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