Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Abstract

Abstract. Electrostatic spinning (Electrospinning, ES) was applied to prepare Donepezil HCl loaded nanofibers as a potential orally dissolving dosage form. Electrospinning of water solutions of different polymers were performed in order to fabricate a consistent and removable web on the collector with ultra-fast dissolution in water based media. Poly(vinyl-alcohol) of low molecular weight was found to be the most appropriate for this purpose. Morphology of the prepared nanofibers was characterized by scanning electron microscope as a function of viscosity and drug content. Diameters of the fibers were between 100 and 300 nm with narrow distribution. In vitro drug release of the webs was immediate (less than 30 s) after immersion independently of their drug content owing to the formed huge surface area, while cast films with the same compositions and commercial tablets needed 30 min or more for complete dissolution. The developed technology for the preparation of orally dissolving web (ODW) formulations is a promising way for producing effective and acceptable dosage forms for children, older people and patients with dysphagia.

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

“…Electrospinning is well-known for its capability of producing nanofibres with enhanced surface area with cryst. SPIR n/a n/a n/a 04.7 17.5 which instantaneous release can be achieved [9,10,53]. Fibres with diameter in the nano range could be produced with PVPK30 and HPMC polymers (data not shown).…”

“…especially favourable in the field of pharmaceutical application [7][8][9][10][11][12][13][14][15][16][17][18]. Although the electrospinning (ES) is fast developing with appearance of tri-axial, coaxial, side-by-side and their combination processes [19][20][21][22] the most common and facile ES equipment is the single needle apparatus [23,24].…”

Nanofibrous solid dosage form of living bacteria prepared by electrospinning

“…Therefore, new, effective, readily accessible and economical lactobacilli-based probiotic therapies are badly needed [41]. It meets the purpose of this work since water-based electrospinning is a simple, scalable and continuous technology with very low energy consumption [8,17,42]. Furthermore, development of effective drug delivery systems for living cells and other biopharmaceuticals is a general need of pharmaceutical technology owing to the newly appearing biomedicals [43].…”

“…oped in the textile industry [5][6][7][8], but in the recent years, applications have been published also in various biomedical fields such as wound dressing [9], wound healing [10], sterile filtration [11], tissue engineering [12,13] and drug delivery [14][15][16][17][18][19]. In former studies bioactive ingredients such as proteins and DNA have been embedded successfully in nanofibers mainly for tissue engineering purposes, while living prokaryotic cells were encapsulated by this technique mainly for industrial application in bioreactors utilizing their metabolic activity [20][21][22].…”

Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions

“…ES is a facile and straightforward process for creating polymeric nanofibres, which can be exploited as carriers for developing a series of new drug delivery systems (DDS) (Ignatious et al, 2010;Kenawy et al, 2002;Nagy et al, 2010;Vigh et al, 2013;Yu et al, 2013). Using ES processes, not only the above-mentioned disadvantages can be eliminated, but also some new types of solid dispersions can be developed for poorly water-soluble drugs, such as third generation solid dispersions and structural solid dispersions (Yu et al, 2011(Yu et al, , 2010.…”