Electrostatic Effects on Dispersion, Transport, and Deposition of Fine Pharmaceutical Powders: Development of an Experimental Method for Quantitative Analysis

Yurteri, Caner Ü.; Mazumder, M.K.; Grable, N.; Ahuja, Gaurav; Trigwell, Steve; Biris, Alexandru S.; Sharma, Rohit; Sims, Robert

doi:10.1080/02726350215330

Cited by 33 publications

(22 citation statements)

References 8 publications

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“…These results indicate that even in a uniform electric field, the polarization of the particle may produce non-uniform rates of ionization as a function of azimuth. Note that an expression analogous to equation (6) cannot in general be obtained analytically if the electric field is non-uniform and transient. As such, equation (6) is not directly used in the model.…”

Section: Streamer Dynamics Intersecting With a Single Particlementioning

confidence: 99%

“…(Note that gas heating in the streamer channel and enhanced droplet evaporation may occur during the latter stages of streamer evolution, for example, during the streamer-to-spark transition.) The purposeful functionalization of the surface of small particles for industrial and pharmaceutical purposes is also of interest 0963-0252/06/040591+12$30.00 © 2006 IOP Publishing Ltd Printed in the UK where the ability to produce radicals inexpensively motivates the use of atmospheric pressure plasmas [6].…”

Section: Introductionmentioning

confidence: 99%

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Streamer dynamics in gases containing dust particles

Babaeva

Bhoj

Kushner

2006

Plasma Sources Sci. Technol.

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Atmospheric pressure plasmas, and streamers in particular, sustained in air often encounter dust or aerosol particles having sizes of a few to tens of micrometres. The dynamics of streamers intersecting such particles are of interest due to their possible use for functionalizing the surfaces of the particles. Using a 2-dimensional plasma hydrodynamics model having an unstructured mesh, the consequences of dust particles on streamer dynamics were investigated while varying the particle size, shape and material properties. We found that while small dielectric particles (< tens of micrometres) are enveloped by the streamer, larger particles can intercept and reinitiate streamers. By increasing the permittivity and capacitance of the particles, streamer interception and re-initiation may also occur on smaller particles. The presence of multiple particles in the path of a streamer can increase the speed of the avalanche front due to synergistic polarization of the particles.

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Section: Streamer Dynamics Intersecting With a Single Particlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Streamer dynamics in gases containing dust particles

Babaeva

Bhoj

Kushner

2006

Plasma Sources Sci. Technol.

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“…Faraday pail [15] Aerosol electrometer apparatus [31,36,38,75] Electrical low pressure impactor (ELPI) [19][20][21][22][32][33][34]37,50] Modified twin stage impinger [79] Electrical next generation impactor (eNGI) [80] Electrical single particle aerodynamic relaxation time (E-SPART) analyser [99,101,102] Bipolar charge measurement system [100] electrostatics of bulk powder handling and spacer devices. On the other hand, interest in the role of charges in inhalation aerosols and lung deposition has only started to grow recently.…”

Section: Static Dynamicmentioning

confidence: 99%

Electrostatics of pharmaceutical inhalation aerosols

Kwok¹,

Chan²

2009

j pharm pharmacol

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Objectives This review focuses on the key findings and developments in the rapidly expanding research area of pharmaceutical aerosol electrostatics. Key findings Data from limited in-vivo and computational studies suggest that charges may potentially affect particle deposition in the airways. Charging occurs naturally in the absence of electric fields through triboelectrification, that is contact or friction for solids and flowing or spraying for liquids. Thus, particles and droplets emitted from pulmonary drug delivery devices (dry powder inhalers, metered dose inhalers with or without spacers, and nebulisers) are inherently charged. Apparatus with various operation principles have been employed in the measurement of pharmaceutical charges. Aerosol charges are dependent on many physicochemical parameters, such as formulation composition, device construction, relative humidity and solid-state properties. In some devices, electrification has been purposefully applied to facilitate powder dispersion and liquid atomisation. Summary Currently, there are no regulatory requirements on characterising electrostatic properties of inhalation aerosols. As research in this area progresses, the new knowledge gained may become valuable for the development and regulation of inhalation aerosol products.

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“…To date, there are no pharmacopoeial methods for charge characterization [45]. Although bipolar charging commonly takes place in industrial processes of pharmaceutical particulates [46], the most prevalent assessment of tribocharging is gained from the Faraday pail method, which provides only limited information in the form of net charge-to-mass ratio [47]. In this work, a novel instrument recently developed in the Wolfson Centre [48] (Figure 1a) to characterise the charge properties of the particulate materials under investigation in the form of charge distribution is used.…”

Section: Introductionmentioning

confidence: 99%

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Adebisi

Kaialy

Hussain

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions, Colloids and Surfaces B: Biointerfaces http://dx.doi.org/10. 1016/j.colsurfb.2016.07.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 4. GLU improved the handling of PXM as it significantly reduced its charge in all the spray dried formulations. Technique could be used to determine appropriate formulations that improve handling AbstractThis work explores the use of both spray drying and D-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging was also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM.XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5 µm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (-3.8 versus 0.5 nC/g for untreated material and -7.5 versus 3.1 nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1 -0.3 3 nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM.

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Electrostatic Effects on Dispersion, Transport, and Deposition of Fine Pharmaceutical Powders: Development of an Experimental Method for Quantitative Analysis

Cited by 33 publications

References 8 publications

Streamer dynamics in gases containing dust particles

Streamer dynamics in gases containing dust particles

Electrostatics of pharmaceutical inhalation aerosols

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

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