Electrostatically Directed Long‐Range Self‐Assembly of Nucleotides with Cationic Nanoparticles To Form Multifunctional Bioplasmonic Networks

Abstract

Precise control over interparticle interactions is essential to retain the functions of individual components in a self-assembled superstructure. Here, we report the design of a multifunctional bioplasmonic network via an electrostatically directed self-assembly process involving adenosine 5'-triphosphate (ATP). The present study unveils the ability of ATP to undergo a long-range self-assembly in the presence of cations and gold nanoparticles (AuNP). Modelling and NMR studies gave a qualitative insight into the major interactions driving the bioplasmonic network formation. ATP-Ca 2 + coordination helps in regulating the electrostatic interaction, which is crucial in transforming an uncontrolled precipitation into a kinetically controlled aggregation process. Remarkably, ATP and AuNP retained their inherent properties in the multifunctional bioplasmonic network. The generality of electrostatically directed selfassembly process was extended to different nucleotidenanoparticle systems.

Structural and Functional Interdependences of Biological Organisms in Extreme Conditions

“…Results of NP-SFI studying using different physical methods and implementation of this paradigm in physics were published in [17][18][19][20][21][22][23][24][25]; continuation of NP-SFI application in physics for interfaces construction was in [26][27][28][29][30][31], as well as studies for biosensors construction [32][33][34][35][36][37][38][39]. Results of SFI at the level of molecules, including biological macromolecules one can find in [40][41][42][43][44][45][46][47][48][49]. The next volume of investigations was done at the level of molecular complexes [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64]…”