Electrostatics of soft charged interfaces with pH-dependent charge density: effect of consideration of appropriate hydrogen ion concentration distribution

Chen, Guang; Das, Siddhartha

doi:10.1039/c4ra13946a

Cited by 31 publications

(41 citation statements)

References 43 publications

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“…A dialysis membrane diffusion method [ 50 ] was utilized to study the in vitro drug release from the optimized nanoemulsion systems. Simulated lung fluids (SLF) at pH 6.5 and 7.4 comprising 0.2% ( w / v ) Tween 80 were used as dissolution media to simulate the lung interstitial fluid in tumor (pH 6.5) and healthy (pH 7.4) environments.…”

Section: Methodsmentioning

confidence: 99%

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Asmawi

Salim

Abdulmalek

et al. 2020

IJMS

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The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor solubility has limited their clinical success. Given this, an aerosolized nanoemulsion system for pulmonary delivery is recommended to mitigate these drawbacks. In this study, DTX- and CCM-loaded nanoemulsions were optimized using the D-optimal mixture experimental design (MED). The effect of nanoemulsion compositions towards two response variables, namely, particle size and aerosol size, was studied. The optimized formulations for both DTX- and CCM-loaded nanoemulsions were determined, and their physicochemical and aerodynamic properties were evaluated as well. The MED models achieved the optimum formulation for DTX- and CCM-loaded nanoemulsions containing a 6.0 wt% mixture of palm kernel oil ester (PKOE) and safflower seed oils (1:1), 2.5 wt% of lecithin, 2.0 wt% mixture of Tween 85 and Span 85 (9:1), and 2.5 wt% of glycerol in the aqueous phase. The actual values of the optimized formulations were in line with the predicted values obtained from the MED, and they exhibited desirable attributes of physicochemical and aerodynamic properties for inhalation therapy. Thus, the optimized formulations have potential use as a drug delivery system for a pulmonary application.

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Section: Methodsmentioning

confidence: 99%

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Asmawi

Salim

Abdulmalek

et al. 2020

IJMS

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“…Firstly, it can be assumed that we operate at that particular pH range (or pH − pK a range), where such morphological and structural changes of the virus are not important. Secondly, and more importantly, the PEL, which is invariably in a polyelectrolyte brush configuration [51][52][53][54][55], has its structure (e.g., the PEL thickness, PEL depth-dependent monomer distribution, etc.) solely dictated by the balance of the non-electrical effects of the polyelectrolyte, namely its entropic elasticity and the volume exclusion effects [56,57].…”

Section: Introductionmentioning

confidence: 99%

Electrostatic potential distribution of a soft spherical particle with a charged core and pH-dependent charge density

McDaniel

Valcius

Andrews

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Further modifications of mean-field approaches for a charged soft surface were developed by accounting for finite ion size [16,17] and pH dependent charge density [18,19].…”

Section: Introductionmentioning

confidence: 99%

Effect of solvent polarization on electric double layer of a charged soft surface in an electrolyte solution

Sin,

Kim,

Sin

2022

Preprint

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We study the electric double layer near a charged soft surface by using a mean-field approach including non-uniform size effect and solvent polarization. Based on a free energy model, electrostatic potential and number densities of water and ions are obtained numerically by solving coupled differential equations including the Poisson's equation. We find that the solvent polarization significantly affects electrostatic potential, ion number densities and permittivity in an electrolyte solution near a charged soft surface. We prove that the consideration of the solvent polarization increases the magnitude of Donnan potential. We also demonstrate that within the fixed charge layer the number densities of counterions and coions are slightly smaller than when the solvent polarization is not considered. An increase in the ionic size enhances the influence of solvent polarization on the electrostatic properties within the fixed charged layer of charged soft surface. In the region of high surface-charge-density, the permittivity and the number density of water dipoles considerably decrease due to water polarization.

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Electrostatics of soft charged interfaces with pH-dependent charge density: effect of consideration of appropriate hydrogen ion concentration distribution

Abstract: Explicit consideration of hydrogen ion concentration for describing the electrostatics of grafted polyelectrolyte layers with pH-dependent charge density exhibits the necessity of considering a non-uniform depth dependent monomer distribution.

Cited by 31 publications

References 43 publications

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Electrostatic potential distribution of a soft spherical particle with a charged core and pH-dependent charge density

Effect of solvent polarization on electric double layer of a charged soft surface in an electrolyte solution

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