Elemental analysis of the liver, kidney, and intestine tissues from a Hodgson's bat (Myotis formosus tsuensis)

Yu, Hee Jeong; Kang, Jung-Hoon; Lee, Seung-Woo; Choi, Yu Jung; Oh, Dayoung; Lim, Jong-Deock; Ryu, Doug-Young

doi:10.14405/kjvr.2016.56.1.51

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…The protein (HemK methyltransferase family member 2) encoded by N6AMT1 gene can transform monomethylarsonous acid to dimethylarsinic acid, conferring resistance of mammalian cells to arsenic-induced toxicity [26]. An elemental analysis in the tissues from the M. rufoniger individual analyzed in the present study showed a very high concentration of arsenic in its intestinal tissue [27], suggesting that the M. rufoniger individual was exposed to food or water highly contaminated with arsenic. In this context, uAACs in N6AMT1 can be considered as a possible chemical adaptation signature.…”

Section: Discussionmentioning

confidence: 89%

Myotis rufonigerGenome Sequence and Analyses:M. rufoniger’s Genomic Feature and the Decreasing Effective Population Size ofMyotisBats

Bhak

Jeon

et al. 2017

Preprint

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Myotis rufoniger is a vesper bat in the genus Myotis. Here we report the whole genome sequence and analyses of the M. rufoniger. We generated 124 Gb of short-read DNA sequences with an estimated genome size of 1.88 Gb at a sequencing depth of 66× fold. The sequences were aligned to M. brandtii bat reference genome at a mapping rate of 96.50% covering 95.71% coding sequence region at 10× coverage. The divergence time of Myotis bat family is estimated to be 11.5 million years, and the divergence time between M. rufoniger and its closest species M. davidii is estimated to be 10.4 million years. We found 1,239 function-altering M. rufoniger specific amino acid sequences from 929 genes compared to other Myotis bat and mammalian genomes. The functional enrichment test of the 929 genes detected amino acid changes in melanin associated DCT, SLC45A2, TYRP1, and OCA2 genes possibly responsible for the M. rufoniger's red fur color and a general coloration in Myotis. N6AMT1 gene, associated with arsenic resistance, showed a high degree of function alteration in M. rufoniger. We further confirmed that the M. rufoniger also has batspecific sequences within FSHB, GHR, IGF1R, TP53, MDM2, SLC45A2, RGS7BP, RHO, OPN1SW, and CNGB3 genes that have already been published to be related to bat's reproduction, lifespan, flight, low vision, and echolocation. Additionally, our demographic history analysis found that the effective population size of Myotis clade has been consistently decreasing since~30k years ago. M. rufoniger's effective population size was the lowest in Myotis bats, confirming its relatively low genetic diversity.

show abstract

Section: Discussionmentioning

confidence: 89%

Myotis rufonigerGenome Sequence and Analyses:M. rufoniger’s Genomic Feature and the Decreasing Effective Population Size ofMyotisBats

Bhak

Jeon

et al. 2017

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…An elemental analysis in the tissues from the M . rufoniger individual analyzed in the present study showed a very high concentration of arsenic in its intestinal tissue [ 27 ], suggesting that the M . rufoniger individual was exposed to food or water highly contaminated with arsenic.…”

Section: Discussionmentioning

confidence: 96%

Myotis rufoniger genome sequence and analyses: M. rufoniger’s genomic feature and the decreasing effective population size of Myotis bats

Bhak

Jeon

et al. 2017

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Myotis rufoniger is a vesper bat in the genus Myotis. Here we report the whole genome sequence and analyses of the M. rufoniger. We generated 124 Gb of short-read DNA sequences with an estimated genome size of 1.88 Gb at a sequencing depth of 66× fold. The sequences were aligned to M. brandtii bat reference genome at a mapping rate of 96.50% covering 95.71% coding sequence region at 10× coverage. The divergence time of Myotis bat family is estimated to be 11.5 million years, and the divergence time between M. rufoniger and its closest species M. davidii is estimated to be 10.4 million years. We found 1,239 function-altering M. rufoniger specific amino acid sequences from 929 genes compared to other Myotis bat and mammalian genomes. The functional enrichment test of the 929 genes detected amino acid changes in melanin associated DCT, SLC45A2, TYRP1, and OCA2 genes possibly responsible for the M. rufoniger’s red fur color and a general coloration in Myotis. N6AMT1 gene, associated with arsenic resistance, showed a high degree of function alteration in M. rufoniger. We further confirmed that the M. rufoniger also has bat-specific sequences within FSHB, GHR, IGF1R, TP53, MDM2, SLC45A2, RGS7BP, RHO, OPN1SW, and CNGB3 genes that have already been published to be related to bat’s reproduction, lifespan, flight, low vision, and echolocation. Additionally, our demographic history analysis found that the effective population size of Myotis clade has been consistently decreasing since ~30k years ago. M. rufoniger’s effective population size was the lowest in Myotis bats, confirming its relatively low genetic diversity.

show abstract

Elemental analysis of the liver, kidney, and intestine tissues from a Hodgson's bat (Myotis formosus tsuensis)

Cited by 2 publications

References 11 publications

Myotis rufonigerGenome Sequence and Analyses:M. rufoniger’s Genomic Feature and the Decreasing Effective Population Size ofMyotisBats

Myotis rufonigerGenome Sequence and Analyses:M. rufoniger’s Genomic Feature and the Decreasing Effective Population Size ofMyotisBats

Myotis rufoniger genome sequence and analyses: M. rufoniger’s genomic feature and the decreasing effective population size of Myotis bats

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