Elemental imaging using laser-induced breakdown spectroscopy: A new and promising approach for biological and medical applications

Busser, Benoît; Moncayo, S.; Coll, Jean‐Luc; Sancey, Lucie; Motto-Ros, Vincent

doi:10.1016/j.ccr.2017.12.006

Cited by 130 publications

(70 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4). Over the past two decades, LIBS has become a recognized and valuable analytical spectroscopic technique for the qualitative or quantitative analysis of the elemental properties of any type of sample [84]. With the Fig.…”

Section: Laser-induced Breakdown Spectroscopymentioning

confidence: 99%

Recent advances of novel technologies for quality consistency assessment of natural herbal medicines and preparations

et al. 2020

View full text Add to dashboard Cite

Quality consistency is one of the basic attributes of medicines, but it is also a difficult problem that natural medicines and their preparations must face. The complex chemical composition and comprehensive pharmacological action of natural medicines make it difficult to simply apply the commonly used evaluation methods in chemical drugs. It is thus urgent to explore the novel evaluation methods suitable for the characteristics of natural medicines. With the rapid development of analytical techniques and the deepening understanding of the quality of natural herbs, increasing numbers of researchers have proposed many new ideas and technologies. This review mainly focuses on the basic principles, technical characteristics and application examples of the chemical evaluation, biological evaluation methods and their combination in quality consistency evaluation of natural herbs. On the bases of chemical evaluation and clinical efficacy, new methods reflecting their pharmacodynamic mechanism and safety characteristics will be developed, and gradually towards accurate quality control, to achieve the goal of quality consistency. We hope that this manuscript can provide new ideas and technical references for the quality consistency of natural drugs and their preparations, thus better guarantee their clinical efficacy and safety, and better promote industrial development.

show abstract

Section: Laser-induced Breakdown Spectroscopymentioning

confidence: 99%

Recent advances of novel technologies for quality consistency assessment of natural herbal medicines and preparations

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Esse crescimento está atrelado às características atraentes da técnica, como a possibilidade de análise direta com mínimo ou nenhum preparo da amostra, a possibilidade de análise in situ, e a sua capacidade multielementar. As aplicações da LIBS podem ser notadas a partir das publicações de artigos de revisão em áreas específicas como: agricultura, 143 alimentos, 144 ambiental, 145 biológicas, 146 farmacêuticas, 147 forense, 148 metalúrgica 149 e resíduos eletrônicos. 5 Assim, as áreas de atuação referidas serão abordadas e os mais recentes avanços da LIBS para análise de diversas amostras serão apresentados.…”

Section: Aplicaçõesunclassified

Laser Induced-Breakdown Spectroscopy (Libs): Histórico, Fundamentos, Aplicações E Potencialidades

Costa¹,

Augusto²,

Castro³

et al. 2019

View full text Add to dashboard Cite

This review attempts to present a broad view of the technique laser-induced breakdown spectroscopy (LIBS), since its origin, fundamentals, sample preparation strategies, use of chemometric tools for data processing, the advantages and limitations with regard to qualitative and quantitative analysis, aplications and future trends as an analytical technique that is in consolidation in analytical chemistry. LIBS is a rapid and versatile, which is able of providing qualitative and quantitative analytical information for practically any sample, in a virtually non-destructive way, without any substantial sample preparation. The instrumentation is simple, robust, compact, and enables remote analysis. The advancement of the LIBS applications in the areas of agriculture, environmental, food, biological/pharmaceutical, forensic, metallurgy and electronic waste were discussed in detail in this review. We consider that this review will be an important tool concerning dissemination of the LIBS, mainly for audience of undergraduate courses, and disciplines related to instrumental analysis.

show abstract

“…L'avantage des techniques utilisant l'ablation laser est néanmoins de permettre d'acquérir des profils de distribution en profondeur afin de créer des images en 3 dimensions avec une résolution latérale de quelques micromètres seulement. L'analyse élémentaire LIBS des tissus biologiques donne des résultats complémentaires à ceux obtenus par des méthodes classiques utilisées en médecine, telles que la microscopie électronique à transmission et l'analyse histologique couplée à l'immunohistochimie [21]. Elle peut être associée à des techniques plus complexes offrant des performances supérieures, mais dans des conditions plus restrictives, comme l'ICP-MS, la nano-SIMS ou la μXRF.…”

Section: Particules Exogènes Post-chirurgicalesunclassified

“…Différentes biopsies humaines cutanées sont comparées à l'analyse histologique classique. HES : coloration hématoxyline/éosine/safran (figure adaptée de[21]).…”

unclassified

L’imagerie élémentaire par spectroscopie LIBS

et al. 2019

Self Cite

View full text Add to dashboard Cite

L’imagerie multi-élémentaire des tissus biologiques grâce à la spectroscopie LIBS (laser-induced breakdown spectroscopy) permet la visualisation directe de la distribution des éléments endogènes ou exogènes. Cette technologie est notamment utilisée pour mettre en image la cinétique des nanoparticules métalliques dans les organes d’élimination, mais également pour analyser la distribution physiologique des éléments biologiques in situ, et pour révéler la topographie des éléments chimiques, comme les métaux, dans des tissus humains qui ont été exposés à des agents extérieurs potentiellement toxiques. Fondée sur notre expérience et les travaux les plus récents dans le domaine de l’imagerie du contenu élémentaire des tissus animaux et humains, cette revue décrit les principes et les caractéristiques de l’instrumentation LIBS, présente certains aspects techniques pour mettre en place des expériences avec cet outil, montre les avantages et les limites de cette technologie, et s’intéresse aux différentes possibilités qu’offre l’imagerie LIBS pour des applications précliniques et médicales.

show abstract

Elemental imaging using laser-induced breakdown spectroscopy: A new and promising approach for biological and medical applications

Cited by 130 publications

References 78 publications

Recent advances of novel technologies for quality consistency assessment of natural herbal medicines and preparations

Recent advances of novel technologies for quality consistency assessment of natural herbal medicines and preparations

Laser Induced-Breakdown Spectroscopy (Libs): Histórico, Fundamentos, Aplicações E Potencialidades

L’imagerie élémentaire par spectroscopie LIBS

Contact Info

Product

Resources

About