Elemental ion release and cytotoxicity of antimicrobial acrylic resins incorporated with nanomaterial

Castro, Denise Tornavoi de; Valente, Mariana Lima da Costa; Aires, Carolina Patrícia; Alves, Oswaldo Luiz; Reis, Andréa Cândido dos

doi:10.1111/ger.12267

Cited by 31 publications

(20 citation statements)

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“…However, in the synthesis of the nanomaterial, 2 mmol of silver nitrate is added while 1 mmol of ammonium metavanadate is added [11], thus expecting a greater release of silver. This greater release of vanadium than silver was also observed in other dental materials incorporated with β-AgVO 3 [31,32].…”

Section: Discussionsupporting

confidence: 74%

Influence of modification of dental porcelains with hybrid nanomaterial on surface characteristics, antimicrobial, chemical, and mechanical properties

Vidal

Ferreira

et al. 2020

Preprint

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Evaluated the effect of incorporation of the nanostructured silver vanadate decorated with silver nanoparticles (β-AgVO3) into dental porcelains on surface characteristics, antimicrobial, chemical, and mechanical properties. The percentages of 2.5% and 5% of β-AgVO3 were incorporated into commercial dental porcelains IPS Inline and Ex-3 Noritake. Surface characteristics were evaluated by SEM/EDS. Antimicrobial activity were investigated against Streptococcus mutans, Streptococcus sobrinus, Aggregatibacter actinomycetemcomitans, and Pseudomonas aeruginosa, by colony counts (CFU/mL), metabolic activity, and multiphoton microscopy. The chemical and mechanical behavior was evaluated by silver (Ag+) and vanadium (V4+/V5+) ions release, microhardness, roughness, and fracture toughness. Statistical tests Kruskal-Wallis and Dunn’s post-hoc were applied for antimicrobial analysis and ions release, and ANOVA and Bonferroni's post-hoc, for mechanical analysis. The nanomaterial interferes in the material’s morphology but does not alter the porcelain’s components. IPS Inline 5% reduced S. mutans and S. sobrinus (p<0.05), and Ex-3 Noritake 5% reduced S. sobrinus (p<0.05). The IPS Inline 2.5% reduced A. actinomycetemcomitans (p<0.05). IPS Inline 5% released more Ag+ (p<0.05), and Ex-3 Noritake 2.5% released more V4+/V5+ (p<0.05). The β-AgVO3 increased the fracture toughness of IPS Inline, the roughness for all groups, and decreased the microhardness of 2.5% group (p<0.05). β-AgVO3 incorporation influenced on morphology but not altered the porcelain’s components, promoted antimicrobial activity against S. mutans, S. sobrinus, and A. actinomycetemcomitans, due to the Ag+ and V4+/V5+ released and influenced the porcelain’s mechanical properties.

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Section: Discussionsupporting

confidence: 74%

Influence of modification of dental porcelains with hybrid nanomaterial on surface characteristics, antimicrobial, chemical, and mechanical properties

Vidal

Ferreira

et al. 2020

Preprint

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“…The silver nanoparticles are reported as low toxicity to human cells; however, this toxicity depends on the concentration incorporated [13, 14]. In the case of AgVO 3 , it was reported that lower concentrations release less silver (Ag) and vanadium (V) ions and avoid risk to patients, since the chemical elements released can be distributed in the body through blood vessels, resulting in cytotoxic effects [15]. The toxicity of AgVO 3 to human cells is still unknown; however, this nanomaterial was reported as cytotoxic to Daphnia similis , an aquatic organism, as a function of Ag [16].…”

Section: Introductionmentioning

confidence: 99%

Endodontic Sealers Modified with Silver Vanadate: Antibacterial, Compositional, and Setting Time Evaluation

Teixeira

Silva

Alves

et al. 2019

BioMed Research International

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The incorporation of nanoparticles into endodontic sealers aims at increasing antimicrobial activity of the original material. Aim. The aim of this study is to incorporate the nanostructured silver vanadate decorated with silver nanoparticles (AgVO3, at 2.5%, 5%, and 10%) into three endodontic sealers and evaluate the antibacterial activity of freshly sealers, surface topography and chemical composition, and setting time. Material and Methods. The AgVO3 was incorporated into AH Plus, Sealer 26, and Endomethasone N at concentrations 0%, 2.5%, 5%, and 10% (in mass). The antibacterial activity of freshly sealers was assessed by direct contact with Enterococcus faecalis and CFU/mL count (n=10), surface topography, and chemical composition were measured by SEM/EDS, and the setting time was measured by Gillmore needle (n=10). The Kruskal-Wallis and Dunn statistical tests were applied (α=0.05). Results. All groups of sealers evaluated inhibited E. faecalis (p>0.05). The incorporation of AgVO3 altered the atomic proportions between components of the endodontic sealers, and the percentage of silver (Ag) and vanadium (V) increased proportionally to the concentrations of AgVO3. Topography analysis showed differences in components distribution on the surface of the specimens. The sealers incorporated with AgVO3 of AH Plus presented a lower setting time than the control group (p<0.05). For Sealer 26 and Endomethasone N, the incorporation of AgVO3 increased the setting time in relation to control group (p<0.05). Conclusions. The modification of endodontic sealers by AgVO3 increased the atomic percentage of Ag and V proportionally to the concentration of the nanomaterial and changed the atomic percentage of the sealer components and setting times. It cannot be affirmed that the AgVO3 promote differences in the antimicrobial activity of freshly sealers, and further investigations of the antimicrobial activity of the set sealers should be carried out.

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“…The percentage of 5% and 10% exhibited significant reductions in impact strength compared with the control group ( P < .001). De Castro et al., 2017 [ 9 ]. Autopolymerizing dental and heat-polymerizing Acrylic Resin 0.5%, 1%, 2.5%, 5% and 10% Metal ions release and cell viability All groups containing AgVO3 showed a significant difference in relation to the control group (0%) regarding the release of Ag and V ions ( P < .0001).…”

Section: Methodsmentioning

confidence: 99%

“…Species of bacteria such as E. faecalis, P. aeruginosa and E. coli remain in the dental canals, even after filling due to the complexity of the anatomy of the canaliculi. Microorganisms such as C. albicans, S. mutans, S. aureus and P. Aeruginosa are adept at total and removable prosthesis bases while S. mutans attach to the ceramic surface, and thus can help in the development of diseases that present high severity, such as bacterial endocarditis, obstructive chronic lung disease, aspiration pneumonia, and generalized respiratory tract infections [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured silver vanadate decorated with silver particles and their applicability in dental materials: A scope review

Campos

Botelho

Reis

2021

Heliyon

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Objectives The present study aims to evaluate which studies evaluated the effectiveness of incorporating silver vanadate into dental materials and to analyze the influence of this incorporation on antimicrobial activity and material properties; Data This review was led by the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist and the JBI Briggs Reviewers Manual to answer the following question: Does the nanostructured silver vanadate decorate with silver particles present anti-microbial activity when incorporated into dental materials without altering its mechanical properties? Source An electronic search without restriction on the dates or languages was performed in PubMed/MEDLINE, Web of Science, Lilacs, Scopus, and Embase up until 2020. The search was specified and limited to the use of the words "nanostructured silver vanadate" in double quotation marks. Study selection The initial search resulted in 55 articles. After an initial assessment and careful reading, 15 studies published between 2014 and 2020 were included in this review. Conclusions With the present scope review, it was possible to observe the good interaction between AgVO 3 and dental materials and have a clarity that it is possible to use them in different types of materials in order to reduce the probability of infections resulting from the biofilm that is installed in them.

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Elemental ion release and cytotoxicity of antimicrobial acrylic resins incorporated with nanomaterial

Abstract: Significant numbers of Ag and V ions were released from resins with higher concentrations of AgVO , presenting cytotoxicity for cells, suggesting that the use of low concentrations is indicated to avoid risks to patients.

Cited by 31 publications

References 30 publications

Influence of modification of dental porcelains with hybrid nanomaterial on surface characteristics, antimicrobial, chemical, and mechanical properties

Influence of modification of dental porcelains with hybrid nanomaterial on surface characteristics, antimicrobial, chemical, and mechanical properties

Endodontic Sealers Modified with Silver Vanadate: Antibacterial, Compositional, and Setting Time Evaluation

Nanostructured silver vanadate decorated with silver particles and their applicability in dental materials: A scope review

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