Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired

Huang, Kangkang; Liang, Yunlai; Wang, Kun; Ma, Yating; Wu, Jiahui; Luo, Huidan; Yi, Bin

doi:10.3389/fcdhc.2022.831128

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…The most obvious possibility is that ACE and ACE2, by regulating the levels of Ang II and/or Ang-(1-7) in pancreatic islets, are involved in the control of insulin secretion to the extent that blood flow is influenced by local levels of angiotensin peptides. This finding of our study is consistent with the previous research [19,20] and might be explained by the higher frequency of CHD in the diabetic population.…”

Section: Discussionsupporting

confidence: 94%

Role of Cigarette Smoking on Serum Angiotensin-Converting Enzyme and Its Association With Inflammation and Lipid Peroxidation

NATH¹,

SHIVASEKAR²

2022

Cureus

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IntroductionCigarette smoking promotes angiotensin-converting enzyme (ACE) production and causes a substantial change in inflammation and oxidative stress, resulting in an increase in antioxidant activity and lipid peroxidation. ObjectiveThe study's goal is to determine the role of cigarette smoking on serum ACE and its relation with inflammatory markers and lipid peroxidation. MethodsThe cross-sectional study consists of three groups. The study participants are all men between the age group of 20 to 55 years. Group 1 includes 120 healthy controls as nonsmokers, Group 2 consists of 120 active smokers with coronary heart disease (CHD) and Group 3 includes 120 active smokers with diabetic CHD patients attending the SRM Medical College Hospital in Tamil Nadu for cardiology and medical Outpatient. Measurements of serum ACE, oxidized low-density lipoprotein (oxLDL), high-sensitivity Creactive protein (hsCRP), and matrix metalloprotease-9 (MMP-9) were performed using the ELISA method (enzyme-linked immunosorbent assay). Using a spectrophotometric approach, the total antioxidant capacity and lipid peroxidation, particularly Malondialdehyde (MDA), were assessed. ResultsThe mean serum ACE (92.35±10.28), oxLDL (48.59±8.56), hs-CRP (5.87±1.62), and MDA (1.146±0.198) levels were significantly (p-value <0.0001) higher in smokers with CHD and diabetes (group 3) when compared to group 1 and group 2. On the other hand, the total antioxidant capacity (0.413±0.097) of smokers of group 3 was found to be (p<0.0001) significantly lower than those of group 1 and group 2. The study also demonstrated a significant correlation between ACE with MDA, ox-LDL, total antioxidant capacity, hs-CRP, MMP-9, smoking load, and smoking intensity in smokers. ConclusionThe study concludes a substantial correlation exists in smokers owing to ACE modification, which results in inflammation and lipid peroxidation activation. This is strongly associated with an increased risk of major cardiovascular events.

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Section: Discussionsupporting

confidence: 94%

Role of Cigarette Smoking on Serum Angiotensin-Converting Enzyme and Its Association With Inflammation and Lipid Peroxidation

NATH¹,

SHIVASEKAR²

2022

Cureus

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“…Several clinical studies reported increased RAAS activity in patients with type 2 diabetes, especially in the presence of DKD (65)(66)(67)(68). RAAS hyperactivity has been well recognized as a critical pathogenetic factor contributing to progression of DKD and CKD towards advanced renal fibrosis and end-stage kidney disease (3).…”

Section: Effects Of Vasopressin On Reninangiotensin-aldosterone Syste...mentioning

confidence: 99%

Metabolic effects of vasopressin in pathophysiology of diabetic kidney disease

Lebedeva,

Margaryan,

Smolyarchuk

et al. 2023

Front. Endocrinol.

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The diabetic kidney disease (DKD) is the major cause of the chronic kidney disease (CKD). Enhanced plasma vasopressin (VP) levels have been associated with the pathophysiology of DKD and CKD. Stimulation of VP release in DKD is caused by glucose-dependent reset of the osmostat leading to secondary pathophysiologic effects mediated by distinct VP receptor types. VP is a stress hormone exhibiting the antidiuretic action in the kidney along with broad adaptive effects in other organs. Excessive activation of the vasopressin type 2 (V2) receptor in the kidney leads to glomerular hyperfiltration and nephron loss, whereas stimulation of vasopressin V1a or V1b receptors in the liver, pancreas, and adrenal glands promotes catabolic metabolism for energy mobilization, enhancing glucose production and aggravating DKD. Increasing availability of selective VP receptor antagonists opens new therapeutic windows separating the renal and extra-renal VP effects for the concrete applications. Improved understanding of these paradigms is mandatory for further drug design and translational implementation. The present concise review focuses on metabolic effects of VP affecting DKD pathophysiology.

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Gene Expression Analysis in T2DM and Its Associated Microvascular Diabetic Complications: Focus on Risk Factor and RAAS Pathway

Jena,

Kaur,

Singh

et al. 2024

Mol Neurobiol

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Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired

Cited by 5 publications

References 41 publications

Role of Cigarette Smoking on Serum Angiotensin-Converting Enzyme and Its Association With Inflammation and Lipid Peroxidation

Role of Cigarette Smoking on Serum Angiotensin-Converting Enzyme and Its Association With Inflammation and Lipid Peroxidation

Metabolic effects of vasopressin in pathophysiology of diabetic kidney disease

Gene Expression Analysis in T2DM and Its Associated Microvascular Diabetic Complications: Focus on Risk Factor and RAAS Pathway

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