Elevated advanced oxidation protein products (AOPPs) indicate metabolic risk in severely obese children

Codoñer‐Franch, Pilar; Tavárez-Alonso, Sandra; Murria-Estal, R.; Tortajada‐Girbés, Miguel; Simó-Jordá, Raquel; Alonso‐Iglesias, Eulalia

doi:10.1016/j.numecd.2010.06.002

Cited by 40 publications

(25 citation statements)

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“…In early puberty, baseline antioxidation markers correlated negatively with prooxidation markers both in the obese and normal-weight subjects. Increased baseline prooxidation (or reduced antioxidation) markers in obese pre-and early pubertal subjects have been reported (6). Also, BMI in children and adolescents has been correlated positively and negatively, respectively, with pro-and antioxidation markers (19).…”

Section: Discussionmentioning

confidence: 97%

“…Also, BMI in children and adolescents has been correlated positively and negatively, respectively, with pro-and antioxidation markers (19). The imbalance between pro-and antioxidation mechanisms observed in obesity might contribute to the pathogenesis of obesity and metabolic syndrome-associated comorbidities (6). Of note, adipose tissue-related aseptic low-grade inflammation might contribute to reduced antioxidant capacity and increase of RONS production (1,5).…”

Section: Discussionmentioning

confidence: 99%

“…Glutathione (GSH) and oxidized glutathione disulfide (GSSG), the enzymes glutathione peroxidase (GPX) and catalase and the so-called total antioxidant capacity (TAC) have been employed as markers of antioxidation (2)(3)(4). Oxidative stress in humans has been associated with obesity and resulting comorbidities (1,5,6). Childhood obesity has been associated with oxidative stress even before comorbidities occur (6,7).…”

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confidence: 99%

“…Oxidative stress in humans has been associated with obesity and resulting comorbidities (1,5,6). Childhood obesity has been associated with oxidative stress even before comorbidities occur (6,7).…”

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Antioxidation improves in puberty in normal weight and obese boys, in positive association with exercise-stimulated growth hormone secretion

et al. 2015

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Background:Oxidative stress is associated with obesity while the evidence for the role of GH in pro-and antioxidation is inconclusive. This study investigates the relationships between growth hormone (GH), pro-and antioxidation in relation to obesity and puberty before and after an acute bout of exercise. Methods: In this case-control study, 76 healthy normalweight and obese, prepubertal and pubertal boys underwent a blood sampling before and immediately after an aerobic exercise bout until exhaustion at 70% maximal oxygen consumption. Markers of prooxidation (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCs)) and antioxidation (glutathione (GSH), oxidized glutathione disulfide (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPX), catalase, and total antioxidant capacity (TAC)) and hormones (GH, insulinlike growth factor (IGF)-1, IGF-BP-3, luteinizing hormone, follicle-stimulating hormone, and testosterone) were measured. results: Baseline and postexercise TBARS and PCs were greater, while baseline GSH, GSH/GSSG ratio, GPX, and TAC were lower in obese than that in normal-weight participants. In all participants, waist was the best negative and positive predictor for postexercise GPX and TBARS, respectively. Baseline TAC was greater in pubertal than that in pre-pubertal participants. In all participants, baseline GH was the best negative predictor for postexercise PCs. Significant positive linear correlation exists between the exercise-associated GH, and GSSG increases in pubertal normal-weight boys. conclusions: Higher prooxidation and lower antioxidation were observed in obese boys, while antioxidation improves with puberty and postexercise, paralleling GH accentuated secretion.o xidative stress defines a state of imbalance between proand antioxidation within the cell (1). Prooxidation refers to mitochondrial and nonmitochondrial mechanisms, which generate reactive oxygen and nitrogen species (RONS), whereas antioxidation refers to the adaptive activation of enzymatic and/ or nonenzymatic mechanisms, which scavenge prooxidants and their products within cells and in extracellular body fluids (1). Because the direct measurement of RONS is difficult to perform, thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCs) have been employed as markers of prooxidation (1). Glutathione (GSH) and oxidized glutathione disulfide (GSSG), the enzymes glutathione peroxidase (GPX) and catalase and the so-called total antioxidant capacity (TAC) have been employed as markers of antioxidation (2-4). Oxidative stress in humans has been associated with obesity and resulting comorbidities (1,5,6). Childhood obesity has been associated with oxidative stress even before comorbidities occur (6,7).Puberty is a maturation period in human development, when sexual characteristics and reproductive competence are developed (8). It is characterized by changes in the dynamically regulated hypothalamic-growth hormone (GH)-insulin-like growth factor (IGF)-1 and hypothalamic-pituitary-gonadal axes (9). ...

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Antioxidation improves in puberty in normal weight and obese boys, in positive association with exercise-stimulated growth hormone secretion

et al. 2015

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“…Of course the results were not compared in term of magnitude since the measured indexes are chemically different, but only in terms of diagnostic potency. To do this the widely accepted ROC curve analysis [37][38][39] was used instead of other statistical procedures such as Passing and Bablok-regression or Passing and Bablok-residuals.…”

Section: Discussionmentioning

confidence: 99%