Elevated circulating endothelial microparticles (EMPs) in prepubertal children born preterm

Μαρκοπούλου, Παναγιώτα; Papanikolaou, Eleni; Loukopoulou, Sofia; Galina, Paraskevi; Papassotiriou, Ioannis; Siahanidou, Tania

doi:10.1038/s41390-021-01655-8

Cited by 3 publications

(7 citation statements)

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“…The study population was derived and extended from a previous study investigating circulating EMPs and EPCs [ 7 , 8 ]; both studies evaluated the associations between circulating EMPs and EPCs with cardiovascular risk factors and several endothelial parameters in prepubertal preterm-born children versus children of similar age who were born full-term. All participants were hospitalized as neonates at “Agia Sofia” Children’s Hospital, Athens, Greece, and followed-up regularly in the follow-up clinic.…”

Section: Methodsmentioning

confidence: 99%

“…Standing height was measured to the nearest 0.1 cm on bare foot using a Harpenden stadiometer (London, UK). Body weight was assessed to the nearest 0.1 kg using a scale (Seca 712, UK) with subjects wearing light clothing [ 7 , 8 ]. Waist and hip circumference were measured to the nearest 0.1 cm over an unclothed abdomen and at minimal respiration [ 7 , 8 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

“…Body weight was assessed to the nearest 0.1 kg using a scale (Seca 712, UK) with subjects wearing light clothing [ 7 , 8 ]. Waist and hip circumference were measured to the nearest 0.1 cm over an unclothed abdomen and at minimal respiration [ 7 , 8 , 41 ]. The waist/hip ratio (WHR) and the BMI, as weight (kg)/[height (m 2 )] ratio, were calculated.…”

Section: Methodsmentioning

confidence: 99%

“…A growing body of evidence has revealed the negative effect of preterm birth on cardiovascular health and endothelial function in later life [ 1 , 2 , 3 , 4 , 5 ]. Potential pathways linking prematurity with increased risk of cardiovascular disease and endothelial dysfunction have been described; increased production of reactive oxygen species levels and/or decreased intracellular antioxidant capacity [ 3 ], immature inflammatory process [ 6 ], increased circulating endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs) [ 7 , 8 ] or dysfunction of EPC subpopulations, such as endothelial colony-forming cells (ECFCs) [ 9 ] in preterm-born individuals are possible pathophysiological mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…EMPs have been proposed as early biomarkers of endothelial activation and damage [ 10 ]; increased numbers of EMPs are indicative of endothelial dysfunction [ 10 , 11 , 12 ]. Previous studies have demonstrated that circulating EMPs are higher in children born prematurely [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Plasma Irisin Levels with Circulating Endothelial Microparticles (EMPs) and Endothelial Progenitor Cells (EPCs) in Children Born Prematurely

et al. 2023

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Prematurity has been linked with endothelial dysfunction in later life. The purpose of this study was to evaluate the association between plasma irisin, an adipomyokine reported to protect the functional integrity of vascular endothelium, and circulating endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs), consisting early biomarkers of endothelial dysfunction, in preterm-born children. We studied 131 prepubertal children; 61 preterm and 70 born at term (controls). Plasma irisin was determined by ELISA. Circulating CD62E(+), CD144(+) and CD31(+)/CD42b(-) EMPs, and CD34(+)/VEGFR-2(+)/CD45(-) and CD34(+)/VEGFR-2(+)/CD45dim EPCs, were determined by flow cytometry. Body mass index, waist-to-hip ratio, neck circumference, systolic and diastolic blood pressure, and biochemical parameters (glucose, lipids, insulin, HOMA-IR) were also evaluated. Plasma irisin was significantly lower (p = 0.001), whereas circulating EMPs and EPCs were higher, in children born prematurely compared to controls. Irisin was recognized as independent predictor for CD144(+) and CD31(+)/CD42b(-) EMPs, CD34(+)/VEGFR-2(+)/CD45(-) and CD34(+)/VEGFR-2(+)/CD45dim EPCs in the total study population, and for CD31(+)/CD42b(-) EMPs in the preterm group. In conclusion, plasma irisin correlates independently with circulating EMP and EPC subpopulations in prepubertal children and in preterm-born ones. Further studies in children will potentially elucidate the link between irisin and the primary stages of prematurity-related endothelial dysfunction.

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Section: Methodsmentioning

confidence: 99%