Elevated Heart-Type Fatty Acid-Binding Protein Levels on Admission Predict an Adverse Outcome in Normotensive Patients With Acute Pulmonary Embolism

Dellas, Claudia; Puls, Miriam; Lankeit, Mareike; Schäfer, Katrin; Cuny, Mayumi; M, Berner; Hasenfuß, Gerd; Konstantinides, Stavros

doi:10.1016/j.jacc.2009.10.078

Cited by 143 publications

(123 citation statements)

References 31 publications

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“…It was shown to predict mortality during one-year observation after myocardial infarction [39,40]. High H-FABP levels were also shown to predict mortality due to acute right heart failure in patients with pulmonary emobolism [41]. H-FABP measurements may also be useful as a sensitive and specific marker of poor outcomes in patients with chronic thromboembolic pulmonary hypertension, including those with previous pulmonary endarterectomy [42].…”

Section: Heart-type Fatty Acid Binding Proteinmentioning

confidence: 99%

Intensive exercise and its effect on the heart: Is more always better?

Kaleta¹,

Lewicka

Dąbrowska−Kugacka

et al. 2017

Cardiol J.

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Section: Heart-type Fatty Acid Binding Proteinmentioning

confidence: 99%

Intensive exercise and its effect on the heart: Is more always better?

Kaleta¹,

Lewicka

Dąbrowska−Kugacka

et al. 2017

Cardiol J.

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“…табл. 9) [244]. Простая шкала, осно ванная на наличии тахикардии и синкопальных состояний, и положительное значение H FABR, применимые «у постели больного», дают прогности ческую информацию, сравнимую с выявлением дис функции ПЖ при ЭхоКГ [245,246].…”

Section: маркеры повреждения миокардаunclassified

Pulmonary embolism: clinical guidelines of European Society of Cardiology (2014).The Task Force of the European Society of Cardiology for diagnosis and management of pulmonary embolism

Редакционная¹

2015

Pulʹmonologiâ (Mosk.)

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РезюмеВ данных Клинических рекомендациях суммированы все современные доказательства по диагностике и лечению тромбоэмболии легочной артерии (ТЭЛА). В отличие от предыдущей версии рекомендаций, в данном документе представлены упрощенные варианты клинических прогностических шкал, подробно рассмотрена стратификация риска летального исхода, включая промежуточные степени риска, представлены новые подходы к АКТ, в т. ч. системному тромболизису и катетерным методам лечения, терапии антагонистом витамина К, определено место новых пероральных антикоагулянтов в терапии ТЭЛА. Ключевые слова: рекомендации, тромбоэмболия легочной артерии, венозный тромбоз, шок, гипотензия, торакалгия, одышка, сердеч ная недостаточность, диагностика, антикоагулянты, тромболизис. SummaryThese clinical recommendations summarized currently available evidence on diagnosis and management of patients with pulmonary embolism. When compared to previous version of recommendations, this document has introduced simplified clinical prognostic scales and a new risk stratifi cation system including intermediate risk. Novel approach to anticoagulant therapy have been also reviewed including systemic thrombolysis, catheter directed treatment, vitamin K antagonists and new oral anticoagulants. Key words: recommendations, pulmonary embolism, venous thromboembolism, shock, hypotension, chest pain, dyspnea, heart failure, diagnosis, anticoagulants, thrombolysis.Тромбоэмболия легочной артерии: клинические рекомендации Европейского общества кардиологов (2014) 526Пульмонология. 2015; 25 (5): 525-552 возникавших в ходе работы над Рекомендациями, надлежало информировать ЕОК и вносить соответ ствующие поправки. Финансирование Рабочей груп пы проводилось за счет средств ЕОК полностью, без участия представителей медицинской промышлен ности.Комитетом ЕОК по Практическим рекомендаци ям проведены наблюдение за процессом подготовки новых Клинических рекомендаций и его координа ция. Члены Комитета также несли ответственность за утверждение новых Клинических рекомендаций. Клинические рекомендации ЕОК активно проана лизированы Комитетом по Практическим рекомен дациям и внешними экспертами. После соответст вующих поправок Рекомендации были одобрены всеми экспертами Рабочей группы. Окончательный документ был утвержден Комитетом по Практичес ким рекомендациям для публикации в журнале European Heart Journal.Задача написания Клинических рекомендаций ЕОК заключается не только в объединении результа тов исследований последних лет, но также и в разра ботке образовательных методик и программ внедре ния Рекомендаций в практическое здравоохранение.Для практического использования Рекоменда ций готовится их краткая («карманная») версия, а также слайды, буклеты с ключевыми положения ми, листовки для неспециалистов и электронная версия для смартфонов и других гаджетов (сокра щенные варианты); с полным текст Рекомендаций опубликован на сайте ЕОК и находится в свободном доступе. Национальным обществам рекомендуется утверждать, переводить на национальные языки и внедрять Клинические рекоме...

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“…Yapılan başka çalışmalarda, kısa dönem ölümleri göstermede, birçok değişken arasında sadece H-FABP'ın bağımsız bir belirleyici olduğu gösterilmiştir 64,65 . Dellas ve ark'ları, H-FABP'nın sadece 30 günlük mortaliteyi değil aynı zamanda uzun dönem prognonuzu göstermede bağımsız bir belirleyici olduğunu tespit ettiler 66 . Konu ile alakalı yapılan çalışmaların hemen hepsinde, H-FABP'ın oldukça yüksek NPD (%99-%100) ile PPD (%28-%71)'e sahip olduğu saptanmıştır [64][65][66][67] .…”

Section: Kalp Tipi Yağ Asidi Bağlayıcı Proteinunclassified

“…Dellas ve ark'ları, H-FABP'nın sadece 30 günlük mortaliteyi değil aynı zamanda uzun dönem prognonuzu göstermede bağımsız bir belirleyici olduğunu tespit ettiler 66 . Konu ile alakalı yapılan çalışmaların hemen hepsinde, H-FABP'ın oldukça yüksek NPD (%99-%100) ile PPD (%28-%71)'e sahip olduğu saptanmıştır [64][65][66][67] . Ayrıca yapılan çalışmalarda, H-FABP'ın kısa dönem prognostik etkinliğinin cTn, BNP, EKO ve BT bulgularından daha değerli olduğu gösterilmiştir 66,67 .…”

Section: Kalp Tipi Yağ Asidi Bağlayıcı Proteinunclassified

“…Konu ile alakalı yapılan çalışmaların hemen hepsinde, H-FABP'ın oldukça yüksek NPD (%99-%100) ile PPD (%28-%71)'e sahip olduğu saptanmıştır [64][65][66][67] . Ayrıca yapılan çalışmalarda, H-FABP'ın kısa dönem prognostik etkinliğinin cTn, BNP, EKO ve BT bulgularından daha değerli olduğu gösterilmiştir 66,67 . PPD'nın diğer belirteçlere göre daha yüksek olması nedeniyle, trombolitik tedavi uygulanacak hastaların seçiminde yardımcı olabileceği belirtilmektedir 63,65,66 .…”

Section: Kalp Tipi Yağ Asidi Bağlayıcı Proteinunclassified

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Pulmoner Embolide Şiddet ve Prognozun Değerlendirilmesi

Kılıç¹

2014

Arşiv Kaynak Tarama Dergisi

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Although technology of diagnosis and treatment continues to improve, the mortality rate of pulmonary embolism remains high. It was detected that more than 10% of the hospital mortality is related to pulmonary embolism. Really, management of this disease is hard. It is a consensus that patients with massif pulmonary embolism, which is characterized hemodynamic impairment, and have indications of aggressive treatments such as thrombolytic. But the issue of treatment of the hemodynamically stable patients with pulmonary embolism accompanied by right ventricular dysfunction is not clear. In last year, because of the cost-effectiveness, it has been reported that lowrisk patients could treated as outpatients. Hence, it is need to make an accurate judgment of pulmonary embolism severity and prognosis. Biomarkers such as brain natriuretic peptide, N-terminal probrain natriuretic peptide, cardiac troponin, and heart-type fatty acid-binding protein are very important indicators of pulmonary embolism severity and short-term prognosis. Furthermore, it was reported that the pulmonary embolism severity index and simplified pulmonary embolism severity index are more suitable assessing the overall mortality and long-term prognosis. It is suggested that they could be used especially in identifying low risk group. In this review, in the recent literature, it will be assessed biomarkers, findings right ventricular dysfunction which were detected by imaging tool, and a few clinical prognostic model for evaluating pulmonary embolism severity and prognosis. Key words: Biomarker; pulmonar mebolis; pulmonary embolism severity index; prognosis; risk evaluation ÖZET Tanı ve tedavideki teknolojik gelişmelere rağmen, pulmoner emboliye bağlı mortalite halen yüksektir. Hastane ölümlerinin %10'dan fazlası pulmoner emboli ile alakalı olduğu tespit edilmiştir. Gerçekten,

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Elevated Heart-Type Fatty Acid-Binding Protein Levels on Admission Predict an Adverse Outcome in Normotensive Patients With Acute Pulmonary Embolism

Abstract: The H-FABP might be a useful biomarker for risk stratification of normotensive patients with acute PE.

Cited by 143 publications

References 31 publications

Intensive exercise and its effect on the heart: Is more always better?

Intensive exercise and its effect on the heart: Is more always better?

Pulmonary embolism: clinical guidelines of European Society of Cardiology (2014).The Task Force of the European Society of Cardiology for diagnosis and management of pulmonary embolism

Pulmoner Embolide Şiddet ve Prognozun Değerlendirilmesi

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