Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: Effect of androgens

González, Betina; Ratner, Laura Daniela; Scerbo, M. Julia; Giorgio, Noelia Paula Di; Poutanen, Matti; Huhtaniemi, Ilpo; Calandra, Ricardo S.; Lux‐Lantos, Victoria; Cambiasso, María Julia; Rulli, Susana B.

doi:10.1016/j.mce.2014.04.005

Cited by 7 publications

(4 citation statements)

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“…Previous clinical and epidemiological studies have also reported associations between puberty onset and autism with mixed results as to whether this relationship is due to precocious or late puberty (Corbett et al, 2020; Knickmeyer, Wheelwright, et al, 2006; Mouridsen & Larsen, 1989; Whitehouse et al, 2011; Yoshimura et al, 2005). In terms of the biological pathways, sex-steroids and aromatization of testosterone and estradiol, have been shown to be important regulators of puberty onset, by acting on kisspeptin neurons, which in turn control gonadotropin hormone-releasing hormone (GnRH) secretion (Gonzalez et al, 2014; Poling & Kauffman, 2013). This pattern is apparent in humans, as evidenced by delayed puberty onset in rare cases of aromatase deficiency in females (Belgorosky et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Medical symptoms and conditions in autistic women

Simantov

Pohl

Tsompanidis

et al. 2021

Autism

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The sex bias in autism diagnosis suggests the involvement of sex-specific endocrine mechanisms during prenatal development, but these hormones affect health throughout life. Therefore, the current study examined the association of autism and autistic traits with conditions and symptoms related to the sex-steroid system in adult women. In total, 1230 women (361 autistic), aged 15–77 years, reported on autistic traits and medical history. Medical diagnoses and symptoms were grouped by unsupervised factor analysis, and associations with autism diagnosis and autistic traits were explored. Higher rates of reproductive system diagnoses (odds ratio = 1.035, p = 0.024), prediabetes symptoms (odds ratio = 1.319, p = 0.001), irregular puberty onset (odds ratio = 1.458, p = 0.009), and menstrual length (odds ratio = 1.368, p = 0.034) and lower rates of metabolic and vascular conditions (odds ratio = 0.654, p = 0.013) were associated with diagnosis. Reproductive system diagnoses (β = 0.114, p = 0.000), prediabetes symptoms (β = 0.188, p = 0.000), menstrual length (β = 0.071, p = 0.014), irregular puberty onset (β = 0.149, p = 0.000), excessive menstruation symptoms (β = 0.097, p = 0.003), and hyperandrogenism symptoms (β = 0.062, p = 0.040) were also associated with autistic traits. Many of the conditions and symptoms found to be associated with autism or autistic traits are also related to conditions of steroid hormones and, specifically, the sex-steroid system. The study suggests an important role for steroids in autistic women, beyond prenatal development. Clinical implications are discussed. Lay abstract Sex-steroids, such as testosterone, are thought to be one of the biological factors implicated in autism. This relies on the sex bias in the diagnosis of autism (boys are approximately four times more likely to be diagnosed than girls) and findings of associations with fetal testosterone levels in traits and abilities related to autism. The current study aimed to examine the association between medical conditions and physical symptoms, which tend to manifest in adulthood, and autism in females. Moreover, we examined their association with autistic traits throughout the spectrum. We focused on autistic women because there is little research focusing on the healthcare needs of autistic women, but those that exist suggest heightened vulnerability, and lower access to medical care. We find that conditions related to steroid hormones function are more frequent in autistic women and that they correlate with autistic traits. Specifically, we found that body mass index, reproductive system diagnoses, prediabetes symptoms, irregular puberty onset, and menstrual irregularities were significantly more frequent in autistic women and were significantly correlated with autistic traits in neurotypical women. The findings have important implications for raising awareness in autistic women of the possibility of medical conditions which might need medical attention. In addition, healthcare providers should consider these associations when performing healthcare maintenance checks and/or screening for autism.

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Section: Discussionmentioning

confidence: 99%

Medical symptoms and conditions in autistic women

Simantov

Pohl

Tsompanidis

et al. 2021

Autism

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“…We hypothesize that androgen can dose-dependently affect aromatase activity directly, or indirectly by regulating other factors such as E 2 and LH. One report suggests that early exposure of females to androgen induces sex-specific organizational changes of aromatase expression in the preoptic area [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome

et al. 2015

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BackgroundThis study aimed to investigate the effect of polycystic ovary syndrome (PCOS) on the association of aromatase activity assessed by estradiol-to-testosterone ratio (E2/T) with body mass index (BMI) in women.MethodsThis was a cohort study in five centers for reproductive medicine in China. Data were collected from July 2012 to December 2013. PCOS patients (n = 785) and non PCOS, healthy, age-matched controls (n = 297) were included. Plasma sex hormones including estradiol (E2), testosterone (T), follicle stimulating hormone (FSH), and luteinizing hormone (LH) were measured by ELISA, together with BMI and E2/T being calculated, on the third day of the menstrual cycle. Aromatase activity in PCOS patients with different BMI, T and E2 levels were compared.ResultsE2/T was significantly lower (P < 0.05) while BMI was significantly increased (P < 0.05) in PCOS than non-PCOS. No significant difference was observed in E2/T among different BMI subgroups of either PCOS or control. Ovarian aromatase activity was decreased in PCOS patients which was independent of BMI. Hyperestrogen promoted ovarian aromatase activity, while hyperandrogen inhibited such activity, both in a dose-dependent, biphasic manner.ConclusionsOvarian aromatase activity was lower in PCOS, which was independent of BMI. New therapeutic strategies can be developed by targeting aromatase activity for treating PCOS women, especially those with obesity.

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“…In the polycystic ovary, the androgens may synthesize by theca cells more than the corresponding cells in a normal ovary. In contrast, the activity of aromatase is lower in granulosa cells of the polycystic ovary, which lead to an imbalance in the production of estrogen and androgen [22]. So, this cannot preclude the importance of an aromatase activity disorder in the etiology of PCOS in women (with primary and secondary type), as there may exist causative mutations in the untranslated regions or within introns.…”

Section: Al-fartosy Ajm Et Almentioning

confidence: 99%

“…Thus, the androgen can dosedependently directly affect on aromatase activity, or indirectly by regulating other factors such as E2 and LH. Some report suggests that early exposure of women to androgen may induce sex-specific organizational changes of aromatase expression in the preoptic area [22]. The role of PRL in PCOS women is still controversial.…”

Section: Al-fartosy Ajm Et Almentioning

confidence: 99%

Intelectin-1 and Endocrinological Parameters in Women with Polycystic Ovary Syndrome: Effect of Insulin Resistance

2020

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Objectives:We aimed to evaluate the effect of insulin resistance (IR) on serum In telectin1 and endocrinological hormones levels in obese and nonobese women with and without polycystic ovary syndrome (PCOS) in Basrah, Iraq. Methods: From 124 women volunteers, 60 patients with primary and 64 patients with secondary, while 56 normal ovulatory women were taken as controls. Their fasting in sulin hormone, intelectin1, antiMullerian hormone, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), estradiol (E2) and testosterones (T) were determined by ELISA methods. BMI, glucose and quantitative insulin sensitivity check index as well as IR was determined by the homeostasis model assessment. Results: A significant changes (P<0.05) were seen in the level of homeostasis model assessmentIR, E2 and T. Levels of antiMullerian hormone, LH, LH/FSH ratio and pro lactin were significantly (P<0.01) increased and level of intelectin1 and E2/T ratio were significantly (P<0.01) decreased, while quantitative insulin sensitivity check index level was not significantly different (P>0.05) between the patients (1 o PCOS and 2 o PCOS) and control groups. On the other hand, our data reported that FSH level was significantly (P<0.05) lower in obese and higher in nonobese patients with PCOS as compared to control group. Conclusion: Levels of intelectin1 and endocrinological hormones have significantly associated with body mass index, IR and physical activity in patients and normal groups and the strategies that can modulate levels of these parameters would improve metabolic disarrangements in women with PCOS.

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Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: Effect of androgens

Cited by 7 publications

References 62 publications

Medical symptoms and conditions in autistic women

Medical symptoms and conditions in autistic women

The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome

Intelectin-1 and Endocrinological Parameters in Women with Polycystic Ovary Syndrome: Effect of Insulin Resistance

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