Elevated IL-8 levels in the drainage vein of resectable Dukes' C colorectal cancer indicate high risk for developing hepatic metastasis

Haraguchi, Masashi; Komuta, Ko; Akashi, Arifumi; Matsuzaki, S; Furui, Junichiro; Kanematsu, Takashi

doi:10.3892/or.9.1.159

Cited by 36 publications

(36 citation statements)

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“…Few studies of the relationship between IL-8 in the drainage veins of solid tumors and clinicopathological factors have been reported. Haraguchi et al 31) reported that in 20 patients with Dukes' C CRC, IL-8 levels in drainage veins were significantly higher in the patients with liver metastases than in those without. We did not assess the relationship between IL-8 levels and hematogenic metastasis, since no GC patient had synchronous hematogenic metastasis, which is common in recurrent CRC, but not in GC.…”

Section: Discussionmentioning

confidence: 99%

The role of circulating IL‐8 and VEGF protein in the progression of gastric cancer

et al. 2003

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Both vascular endothelial growth factor (VEGF) and interleukin 8 (IL-8) play an important role in the progression of gastric cancer (GC). In this study, we investigated whether circulating levels of VEGF or IL-8 in drainage veins of GC patients were correlated with any clinicopathological factors. Thirty-seven patients with primary GC who underwent gastrectomy at our department between 1999 and 2002 were analyzed. Blood samples were drawn from a peripheral vein just before surgery and from a drainage vein immediately after laparotomy. Plasma VEGF levels were significantly higher than those in 10 healthy controls. There was no correlation between VEGF levels in drainage veins and any clinicopathological variable, whereas there was a significant relationship in the case of VEGF levels in peripheral veins; the levels were higher in patients with venous invasion. We found a significant relationship between IL-8 levels in drainage veins and both tumor size and lymph node metastasis, whereas no significant relationship between IL-8 levels in peripheral veins and any variable was found. There was no correlation between VEGF and IL-8 levels in drainage veins. Large tumors, deeply invasive tumors, lymph node involvement, venous invasion and high IL-8 levels in drainage veins were all significantly associated with shorter diseasefree survival, although multivariate analysis revealed that lymph node involvement was the only independent prognostic factor. In conclusion, the measurement of IL-8 levels in drainage veins of GC patients may reflect production mainly by the primary lesion and is valuable as an indicator of risk for recurrent disease.

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Section: Discussionmentioning

confidence: 99%

The role of circulating IL‐8 and VEGF protein in the progression of gastric cancer

et al. 2003

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“…A marked increase in VEGF levels has been observed in various types of cancer including anal carcinoma (Kusumanto et al, 2003), lymphoma (Salven et al, 1999a), lung cancer (Salgado et al, 1999;Yanagawa et al, 1999;Matsuyama et al, 2000;Kishiro et al, 2002), gastric carcinoma (Hyodo et al, 1998;Kraft et al, 1999;Yoshikawa et al, 2000), ovarian cancer (Hyodo et al, 1998;Tempfer et al, 1998;Kraft et al, 1999;Yoshikawa et al, 2000), renal cell carcinoma (Dosquet et al, 1997;Sato et al, 1999;Jacobsen et al, 2002;Ljungberg et al, 2003), brain tumour (Stockhammer et al, 2000), hepatocellular carcinoma (Poon et al, 2001), breast cancer (Bando et al, 2005;O'Riain et al, 2005), prostate cancer (Kaushal et al, 2005;Li et al, 2005) and colorectal cancer (Haraguchi et al, 2002;Karayiannakis et al, 2002;Werther et al, 2003). Of these, the last three are most extensively studied.…”

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confidence: 99%

“…Studies on VEGF levels in urine (Bok et al, 2001), pleural effusion (Kraft et al, 1999;Thickett et al, 1999;Yanagawa et al, 1999;Kishiro et al, 2002;Toi et al, 2002), tumour cytosol (Obermair et al, 1997;Eppenberger et al, 1998;Baker et al, 2000;Broll et al, 2001;Foekens et al, 2001;Haraguchi et al, 2002;Toi et al, 2002;Manders et al, 2003;Desruisseau et al, 2004;Bando et al, 2005), tumour cyst fluid (Stockhammer et al, 2000) and other body fluids are available. However, most do not have a basis of comparison, as they report only the VEGF levels in cancer patients, but no control equivalent in healthy volunteers.…”

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confidence: 99%

Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer

2007

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Vascular endothelial growth factor (VEGF) is a major target for the inhibition of tumour vascularisation and the treatment of human cancer. Many tumours produce large quantities of VEGF, and as a result, diagnosis and prognosis of cancer may be predicted by measuring changes in VEGF concentrations in blood. In blood, the VEGF may be located in the plasma, or in the blood-borne cells and formed elements, in particular, platelets and leukocytes. In this study, we collate the measurements of VEGF in platelets, leukocytes, plasma and serum for breast, prostate, colorectal and other cancers. In addition, we analysed the concentration of VEGF in tumour tissue itself, as well as for other tissues in the human body. Although the concentration of VEGF in tumours is high, the size of tumours is small compared to other tissues, in particular, skeletal muscle. Thus, the total quantity of VEGF in tumours and in blood is small compared to the quantity in muscles. This large reservoir of VEGF may have important implications for the treatment of cancer.

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“…Notably, IL-8 is highly expressed in hyperplastic mucosa adjacent to colon cancer, supporting an indirect angiogenic effect of colon cancer cells (15). Moreover, IL-8 is apparently involved in development of distant metastasis from colorectal cancer (16). Interestingly, both colonic epithelial cells (17) and microvascular EC of human gut secrete IL-8 in a regulated fashion in vitro (18), suggestive of a cross-talk between those cells in the human intestinal mucosa (19).…”

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Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2

Heidemann¹,

Ogawa²,

Dwinell³

et al. 2003

Journal of Biological Chemistry

432

321

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Elevated IL-8 levels in the drainage vein of resectable Dukes' C colorectal cancer indicate high risk for developing hepatic metastasis

Cited by 36 publications

References 0 publications

The role of circulating IL‐8 and VEGF protein in the progression of gastric cancer

The role of circulating IL‐8 and VEGF protein in the progression of gastric cancer

Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer

Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2

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