Elevated levels of circulating matrix metalloproteinase-9 are associated with a dysregulated cortisol rhythm—A case-control study of coronary artery disease

Szymanowski, Aleksander; Nijm, Johnny; Kristenson, Margareta; Jonasson, Lena

doi:10.1016/j.psyneuen.2010.06.012

Cited by 16 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasma and serum levels of MMP-9 and MMP-8 did not differ between patients and controls (Table 6), This is in agreement with several studies reporting similar levels of MMP-9 in stable CAD patients and controls (50,51,60,147), although others have reported higher circulating levels in patients with stable symptoms (48,49,120). A few earlier studies have also shown increased levels of circulating MMP-8 in stable CAD compared to healthy controls (66,157).…”

Section: Serum and Plasma Levels Of Mmps And Timpssupporting

confidence: 89%

“…Moreover, CAD patients were found to release significantly less cortisol than controls when they were exposed to acute physical or psychological stress. The blunted cortisol response was associated with increased levels of CRP the day after stress and also, there was evidence for dysregulated post-stress levels of MMP-9 in the patient group (119,120). Similarly, a blunted cortisol response to stressful stimuli has been demonstrated in chronic inflammatory diseases such as rheumatoid arthritis and allergic asthma (121,122).…”

Section: Dysregulation Of Hpa Axis Activity In Cad Patientsmentioning

confidence: 81%

“…A later study of CAD patients showed an increased total release of cortisol per day as well as significantly higher levels of evening cortisol compared to healthy controls, the latter indicating a flattened cortisol diurnal rhythm (117,118). Interestingly, the increased levels of evening cortisol also correlated with basal morning levels of CRP, IL-6 and MMP-9 (102,119,120). Moreover, CAD patients were found to release significantly less cortisol than controls when they were exposed to acute physical or psychological stress.…”

Section: Dysregulation Of Hpa Axis Activity In Cad Patientsmentioning

confidence: 94%

See 2 more Smart Citations

Leukocyte-derived matrix metalloproteinase-9 in patients with coronary artery disease : Associations with psychological stress and glucocorticoid sensitivity

Jonsson¹

2015

View full text Add to dashboard Cite

Section: Serum and Plasma Levels Of Mmps And Timpssupporting

confidence: 89%

Section: Dysregulation Of Hpa Axis Activity In Cad Patientsmentioning

confidence: 81%

Section: Dysregulation Of Hpa Axis Activity In Cad Patientsmentioning

confidence: 94%

See 1 more Smart Citation

Leukocyte-derived matrix metalloproteinase-9 in patients with coronary artery disease : Associations with psychological stress and glucocorticoid sensitivity

Jonsson¹

2015

View full text Add to dashboard Cite

“…Although we did not have a large enough sample to do a full mediation analyses, adding IL-6 to our ANCOVA model did not alter the relationship between the blunted NCR and elevated CIMT. This does not preclude the notion of an inflammatory pathway mediating the observed relationship, since other inflammatory factors could play a role in this process, particularly cytokines related to vascular function, such as matrix metalloproteinase-9 (Szymanowski et al, 2011). Given the role of cortisol in modulating immune system function (Desantis et al, 2012), further study of obesity-related inflammatory factors in the context of HPA activity and their contribution to sub-clinical atherosclerosis risk are warranted.…”

Section: Discussionmentioning

confidence: 99%

Blunted nocturnal cortisol rise is associated with higher carotid artery intima-media thickness (CIMT) in overweight African American and Latino youth

Toledo-Corral

Myers

et al. 2013

Psychoneuroendocrinology

View full text Add to dashboard Cite

Background Blunted diurnal cortisol variation has been associated with overt cardiovascular disease in adults. The relationship between the diurnal cortisol variation and subclinical atherosclerosis in youth has yet to be investigated. The objectives of this study were to: 1) determine the relationship between overnight cortisol measures and CIMT in overweight and obese, African-American and Latino children; 2) assess ethnic differences in these relationships and 3) explore whether overnight cortisol and CIMT relationships were independent of inflammatory markers, C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Methods One hundred and fifty-six overweight and obese African-American and Latino children (ages 8–17, 86M/70F, 55 African-American /101 Latino) underwent measures of CIMT by B-mode ultrasound, nocturnal cortisol rise (NCR=salivary cortisol rise from 2200hrs to awakening at 0530hrs), cortisol awakening response (CAR=salivary cortisol from time of awakening to 30 min later), fasting serum cortisol and overnight urinary free cortisol. Results Using linear regression, salivary cortisol0530hrs and NCR were negatively associated with CIMT (βstandardized = −0.215 and −0.220, p<0.01) independent of age, height, percent body fat, ethnicity and systolic blood pressure. Nocturnal salivary cortisol2200hrs, morning serum cortisol, and overnight urinary free cortisol were not associated with CIMT. Using ANCOVA, participants with LOW NCR (NCR <0.44µg/dL, n=52) had significantly greater CIMT than those with HIGH NCR (NCR ≥0.91 µg/dL, n=52; 0.632±0.008 vs. 0.603±0.008mm p=0.01) after controlling for covariates. Ethnicity was independently associated with CIMT, whereby African-American children had greater CIMT than Latino children (−0.028±0.009, p=0.006). The relationships between cortisol measures and CIMT did not differ between the two ethnic groups (all pinteraction=0.28–0.97). CRP, IL-6 and TNF-α were not associated with CIMT (p>0.05). IL-6 was inversely related to NCR (r=−0.186, p=0.03), but it did not explain the relationship between NCR and CIMT. Conclusions Salivary cortisol0530hrs and NCR, but not CAR, nocturnal salivary cortisol 2200hrs, morning serum cortisol or overnight urinary free cortisol, were associated with CIMT, independent of relevant covariates, including inflammatory factors. A low awakening salivary cortisol or a blunted NCR may be related to increased atherosclerosis risk in overweight and obese minority youth. These findings support adult studies suggesting flattened daytime diurnal cortisol variation impacts cardiovascular disease risk.

show abstract

“…Failure in the regulation of MMP-9 in the systemic circulation of coronary artery disease patients has been hypothesized by a dysfunctional cortisol response. The regulation of MMP-9 in the patients is by hypothalamicpituitary-adrenal axis dysfunction, and this MMP-9 has a possibility in staying as a link between cardiovascular disease and stress [59,60].…”

Section: Action In Other Disease Conditionsmentioning

confidence: 99%

Matrix Metalloproteinases 2 and 9 in Avocation of Multitudinal Complications in Explicitly to Carcinoma: Review

Robertson

Rajan

et al. 2016

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Matrix metalloproteinases (MMPs) are a large group of calcium-dependent zinc containing endopeptidases which are mainly concerned with the remodeling of tissue along with degradation of the extracellular matrix. At the present scenario, there is knowledge of about 26 MMPs which are found to be highly regulated by the growth hormones, cytokines, etc., present within the body. At times of normal homeostasis, their levels within the body are low, and their number usually increases at times of pathological conditions. Its generation is known to occur from the pro-inflammatory cells and connective tissues. They may even lead to the process of apoptosis by its interactions with surface receptors. In the clinical trials sectors, various MMPs along with their inhibitors are examined to import the properties of being a high biomarker in the cancer diagnosis, antiangiogenic agents, various other disorders such as chronic allograft nephropathy, diabetic nephropathy, cardiovascular diseases, neuropathic pain, wound healing, angiogenesis processes, immune response, corneal ulceration, embryonic development, and nervous system disorders. As a result, enormous number of studies on this particular enzyme in the marking of cancer and their elevation in the above-mentioned diseases has to be carried out so that it would remain as a useful tool in their diagnosis. The present work is designed to emphasize the concise review of MMPs, in particularly MMP-2 and MMP-9 along with their variant roles, keeping in mind, that it would be advantageous for the researchers to bring out more promising results and to intensify diagnosis of various infirmities, especially in cancer.

show abstract

Elevated levels of circulating matrix metalloproteinase-9 are associated with a dysregulated cortisol rhythm—A case-control study of coronary artery disease

Cited by 16 publications

References 23 publications

Leukocyte-derived matrix metalloproteinase-9 in patients with coronary artery disease : Associations with psychological stress and glucocorticoid sensitivity

Leukocyte-derived matrix metalloproteinase-9 in patients with coronary artery disease : Associations with psychological stress and glucocorticoid sensitivity

Blunted nocturnal cortisol rise is associated with higher carotid artery intima-media thickness (CIMT) in overweight African American and Latino youth

Matrix Metalloproteinases 2 and 9 in Avocation of Multitudinal Complications in Explicitly to Carcinoma: Review

Contact Info

Product

Resources

About