Elevated Peripheral Blood Monocyte Fraction in Nonalcoholic Fatty Liver Disease

Kim, Hack‐Lyoung; Chung, Gyung Ho; Park, In Young; Choi, Jin Man; Hwang, Se-Min; Lee, Jeong-Hoon; Kim, Dong‐Hee

doi:10.1620/tjem.223.227

Cited by 16 publications

(14 citation statements)

References 28 publications

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Section: Discussionsupporting

confidence: 93%

“…TLC was found to be an independent predictor of the occurrence of NAFLD in the studied patients and the occurrence of fibrosis among NAFLD patients in the current study. This agrees with Kim HL et al 19 and Chung GE et al 20 and could be explained by the state of systemic inflammation in NAFLD patients and endotoxin production from the fat stores. The accumulation of lipophilic persistent organic pollutants (POPs) in the adipose tissue leads to its slow release into the bloodstream.…”

Section: Discussionsupporting

confidence: 92%

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Serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis among Egyptian patients with non‐alcoholic fatty liver disease

et al. 2017

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Background and AimMany studies have found a relationship between hepatic iron, serum ferritin, and non‐alcoholic fatty liver disease (NAFLD) or its progress. The aim of this study is to assess the value of serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis in NAFLD.MethodsThis study included 113 subjects who were classified into three groups. Group I included 30 healthy subjects as control with no clinical, radiological, and histological features of NAFLD. Group II included 31 NAFLD patients without hepatic fibrosis. Group III included 52 patients with hepatic fibrosis on top of NAFLD.ResultsSerum ferritin was determined using ferritin ELISA kit. Fibrosis 4 score was calculated. Liver biopsy was conducted for included patients. Significantly higher levels of serum ferritin were found in patients with hepatic fibrosis on top of NAFLD than controls. Receiver operating characteristic curve analysis revealed that an optimum cutoff level of 51.95 ng/mL was the best to predict fibrosis on top of NAFLD with diagnostic sensitivity and specificity of 65% and 60%, respectively, and area under the curve = 0.658.ConclusionHigher serum ferritin was found in patients with hepatic fibrosis on top of NAFLD. Serum ferritin was found to be a predictor of fibrosis on top of NAFLD with moderate sensitivity and specificity.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis among Egyptian patients with non‐alcoholic fatty liver disease

et al. 2017

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“…It has been shown that the phenotypes, morphology, and transcriptome of the splenic monocytes resemble those of blood monocytes . Importantly, Kim et al reported that circulating monocytes were increased in patients with NAFLD compared with normal subjects, suggesting an association between the number of circulating monocytes and hepatic inflammation. Our data here showed a positive correlation between the percentages of monocytes in the spleen and hepatic mRNA abundance of Ccl2 , a chemokine that mediates monocyte recruitment .…”

Section: Discussionmentioning

confidence: 99%

Blackcurrant (Ribes nigrum) Prevents Obesity‐Induced Nonalcoholic Steatohepatitis in Mice

Lee

Pham

Bae

et al. 2018

Obesity

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Objective: With increasing prevalence of nonalcoholic steatohepatitis (NASH), effective strategies to prevent NASH are needed. This study investigated whether the consumption of blackcurrant (Ribes nigrum) can prevent the development of obesity-induced NASH in vivo. Methods: Male C57BL/6J mice were fed a low-fat control diet, a low-fat diet with 6% whole blackcurrant powder, an obesogenic high-fat/high-sucrose control diet (HF), or a high-fat/high-sucrose diet containing 6% whole blackcurrant powder (HF-B) for 24 weeks. Results: HF significantly increased, whereas HF-B markedly decreased, liver weights and triglyceride. Furthermore, blackcurrant attenuated obesity-induced infiltration of macrophages in the liver, in particular, the M1 type, and also suppressed the hepatic expression of fibrogenic genes and fibrosis. Flow cytometric analysis showed that HF significantly increased the percentages of monocytes of total splenocytes, which was markedly attenuated by blackcurrant. HF-B decreased lipopolysaccharide-stimulated mRNA expression of interleukin 1β and tumor necrosis factor α in splenocytes, compared with those from HF controls. Moreover, the levels of circulating and hepatic miR-122-5p and miR-192-5p, known markers for nonalcoholic fatty liver disease, were significantly increased by HF but decreased by HF-B. Conclusions: The study's findings indicate that blackcurrant consumption prevents obesity-induced steatosis, inflammation, and fibrosis in the liver.

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“…However, although gender was accounted for during the analysis, the results of that study were not stratified according to gender and the criteria used to determine quartiles of patients based on WBC count were not gender-specific. In contrast, we analysed the data according to gender as WBC counts differ significantly between men and women [18, 19]. …”

Section: Discussionmentioning

confidence: 99%

Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease

Chung

Yim

Kim

et al. 2016

Gastroenterology Research and Practice

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Aims. Chronic low-grade inflammation is thought to be associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study aimed to determine the association between serum white blood cell (WBC) counts and the development of incidental NAFLD. Methods. In this retrospective longitudinal cohort study, we recruited participants who underwent abdominal ultrasonography and blood samplings during medical checkups in both 2005 and 2010. A total of 2,216 subjects were included in our analyses. Results. The prevalence of NAFLD in 2010 increased steadily in conjunction with increasing WBC counts in 2005 after adjustment for body mass index (BMI) [odds ratio (OR) 2.44, 95% confidence interval (CI) = 1.49–4.00 for women and OR 2.42, 95% CI = 1.61–3.63 for men, lowest quartile versus highest quartile]. Multivariate regression analysis after adjusting for age, BMI, hypertension, smoking, triglycerides, HDL cholesterol, and glucose levels revealed that NAFLD was significantly associated with the highest WBC quartile compared to the lowest quartile [OR 1.85, 95% CI, 1.10−3.10 for women and OR 1.68, 95% CI, 1.08−2.61 for men]. Conclusions. We demonstrated that the risk of developing NAFLD was significantly associated with WBC counts independently of metabolic factors. This finding provides novel evidence indicating that serum WBC counts may be potential surrogate markers of NAFLD.

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Elevated Peripheral Blood Monocyte Fraction in Nonalcoholic Fatty Liver Disease

Cited by 16 publications

References 28 publications

Serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis among Egyptian patients with non‐alcoholic fatty liver disease

Serum ferritin as a non‐invasive marker in the prediction of hepatic fibrosis among Egyptian patients with non‐alcoholic fatty liver disease

Blackcurrant (Ribes nigrum) Prevents Obesity‐Induced Nonalcoholic Steatohepatitis in Mice

Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease

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