Elevated phthalates' exposure in children with constitutional delay of growth and puberty

Xie, Chang-ming; Zhao, Yan; Gao, Lianlian; Chen, Jiao; Cai, Duan; Zhang, Yunhui

doi:10.1016/j.mce.2015.03.006

Cited by 51 publications

(31 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…AGD, areola/nipple regression, testicular descent and preputial separation in male rats are androgen dependent factors, sensitive to endocrine disruptors such as DBP, particularly when exposure occurs in-uterus [22,50,51]. Changes in these parameters could indicate a delayed onset of puberty, impaired sexual behavior, or even infertility in adulthood [21,52,53]. Exposure to DBP did not alter body weight, but it reduced relative AGD and testosterone levels, mainly in DBP500 compared to CN, confirming the anti-androgen role of DBP on reproductive tract development [10,16,51,54,55].…”

Section: Discussionmentioning

confidence: 99%

“…One was killed on postnatal day 1 (PND1) and the other on postnatal day 21 (PND21). androgen-dependent organs respond by masculinizing the tissues [2,10,11,[17][18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

“…Since DBP acts as an anti-androgen substance [23] and androgens are essential to prostate morphogenesis [17,28], in addition to the fact that different doses seems to cause different effects, the aim of this study was to investigate the effects of DBP on prostate devel-…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alterations in prostate morphogenesis in male rat offspring after maternal exposure to Di-n-butyl-phthalate (DBP)

Santos

Silveira

Rinaldi

et al. 2017

Reproductive Toxicology

View full text Add to dashboard Cite

Prostate morphogenesis is regulated by androgens hormones and modulated by morphogenetic proteins such as Bone Morphogenetic Proteins (BMPs). This study aims to investigate the effects on prostate development in male offspring and differentiation after gestational and lactational maternal exposure to Di-n-butyl-phthalate (DBP), an important environmental contamination. Pregnant Wistar rats received 100 or 500mg/kg of DBP (DBP100 and DBP500), by gavage, from gestation day 15 (GD15) until postnatal day 21 (PND21). The pups were euthanized on PND1 and PND21. Anogenital distance and testosterone levels decreased in animals from exposed mothers (DBP100 and 500) on PND1. A three-dimensional reconstruction model of the prostatic urethra showed reduction in the prostatic buds in the DBP500 group. AR expression and α-actin immunoreactivity decreased, and BMP-4 expression was lower on PND1 for DBP500. These results showed that DBP exposure, especially at a higher dose, delayed prostate morphogenesis by reducing the testosterone/AR axis and BMP-4 expression.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alterations in prostate morphogenesis in male rat offspring after maternal exposure to Di-n-butyl-phthalate (DBP)

Santos

Silveira

Rinaldi

et al. 2017

Reproductive Toxicology

View full text Add to dashboard Cite

show abstract

“…Зависимость отображает снижение по-казателя роста с повышением концентрации монометилфталата в моче мальчиков одной возрастной группы. Полученные данные для мальчиков 7 лет подтверждают проведенные ранее исследования о связи между содержанием монофталатов в моче и конституциональной задержкой роста у мальчиков [17].…”

Section: результаты и их обсуждениеunclassified

“…Фталаты обладают антиандрогенным свойством. При изучении показателей роста в период поло-вого созревания у мальчиков в зависимости от концентрации метаболитов фталатов в биологи-ческих средах обнаружен повышенный уровень содержания монофталатов в моче детей с низким ростом и задержкой полового развития [17].…”

Section: Introductionunclassified

Study of Correlation between Growth Rate of Children and Monophtalate Concentrations in Urine

Zavernenkova¹,

Karnazhitskaya²,

Ulanova³

et al. 2017

CBE

View full text Add to dashboard Cite

1 Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения, Пермь E-mail: tdkarn@fcrisk.ru 2 Пермский национальный исследовательский политехнический университет 3 Пермский государственный национальный исследовательский университет Представлены результаты исследований по определению ме-таболитов фталатов в моче детей дошкольного и младшего школьного возрастов методом ВЭЖХ/МС, изучена зависимость показателя роста детей от концентрации метаболитов фталатов в моче. Обнаружено присутствие метаболитов фталатов (моно-метилфталата, монобутилфталата, моноэтилгексилфталата) в моче детей в диапазоне концентраций 0,0004-0,012 мг/дм 3 . Анализ зависимостей «концентрация метаболитов фталатов в моче -показатель роста» выявил статистически значимую обратно пропорциональную зависимость показателя роста мальчиков 7 лет от концентрации монометилфталата в моче (R 2 =0,38; р<0,05). Ключевые слова: фталаты, монофталаты, высокоэффектив-ная жидкостная хроматография/масс-спектрометрия, показа-тель роста. The study presents the results of determining of phthalate metabolites in urine of pre-school and primary school children by HPLC/MS. The correlation between growth rate of children and the concentration of phthalate metabolites in their urine was examined. The detected range of phthalate metabolite concentrations (mono-methyl phthalate, mono-butyl phthalate, mono-ethylhexyl phthalate) in urine of children was 0.0004-0.012 mg/dm 3 . The analysis of dependencies «urinary concentrations of phthalate metabolites and children growth rate» has revealed statistically significant inversely proportional dependence of the growth rate of the 7 years old boys on the urinary concentration of mono-methyl phthalate (R 2 =0.38; р<0.05). Study of Correlation between Growth

show abstract

Internal plasticization of poly(vinyl chloride) by grafting acrylate copolymers via copper‐mediated atom transfer radical polymerization

Schneider²,

Hoeglund³

et al. 2021

J of Applied Polymer Sci

View full text Add to dashboard Cite

Internal plasticization of poly(vinyl chloride) (PVC) was achieved in one‐step using copper‐mediated atom transfer radical polymerization to graft different ratios of random n‐butyl acrylate and 2–2‐(2‐ethoxyethoxy)ethyl acrylate copolymers from defect sites on the PVC chain. Five graft polymers were made with different ratios of poly(butyl acrylate) (PBA) and poly(2–2‐(2‐ethoxyethoxy)ethyl acrylate) (P2EEA); the glass transition temperatures (Tg) of functionalized PVC polymers range from − 25 to − 50°C. Single Tg values were observed for all polymers, indicating good compatibility between PVC and grafted chains, with no evidence of microphase separation. Plasticization efficiency is higher for polyether P2EEA moieties compared with PBA components. The resultant PVC graft copolymers are thermally more stable compared to unmodified PVC. Increasing the reaction scale from 2 to 14 g produces consistent and reproducible results, suggesting this method could be applicable on an industrial scale.

show abstract

Elevated phthalates' exposure in children with constitutional delay of growth and puberty

Cited by 51 publications

References 53 publications

Alterations in prostate morphogenesis in male rat offspring after maternal exposure to Di-n-butyl-phthalate (DBP)

Alterations in prostate morphogenesis in male rat offspring after maternal exposure to Di-n-butyl-phthalate (DBP)

Study of Correlation between Growth Rate of Children and Monophtalate Concentrations in Urine

Internal plasticization of poly(vinyl chloride) by grafting acrylate copolymers via copper‐mediated atom transfer radical polymerization

Contact Info

Product

Resources

About