Elevated plasma D-dimer as a predictor of postoperative complications after radical cystectomy

Abstract

Detailed preoperative evaluation is essential in prevention of perioperative complications. As thorough anamnesis, physical examination and standard laboratory investigation do not contribute much in prediction of perioperative complications and outcome, and detection of tumor markers is also insufficient in means of prognosis, some molecular marker have emerged lately as prognostic markers in surgery. Recent data on pathophysiological processes stress response, derangements of hemostasis, in sepsis or in thromboembolism as well as in malignancy, indicate that presence or elevation of some molecular markers of fibrinolysis can indicate possibility of perioperative complications and even predict outcome. As it is evident that neoplastic cells enhance thrombin and other procoagulant production, detection of degree of activation of coagulation and fibrinolysis can contribute in prediction of treatment outcome in patients with bladder carcinoma scheduled for radical surgical procedures.

A simple fabricated microfluidic chip for urine sample-based bladder cancer detection

“…Nuclear matrix protein22 (NMP22), bladder tumor antigen (BTA) and fibrin degradation products (FDP) were chosen because they have been authenticated by the Food and Drug Administratio and used by researchers [38][39][40][41][42][43]. Then, NMP22 (USCN, China), CFHL1 (Sino Biological, China), which is a fragment of complement factor H-related protein [44], and D-dimer (Fitzgerald, USA), which is the final product and only specific marker of fibrinolysis [45], were chosen as the standard proteins corresponding to NMP22, BTA and FDP, respectively. Then, they were diluted to gradient concentration solutions ranging from 0-16 ng ml −1 [46], 0-60 ng ml −1 [47] and 0-32 µg ml −1 [48] with intervals of 4 ng ml −1 , 15 ng ml −1 and 8 µg ml −1 , respectively.…”

Alterações hemostáticas e clínicas em cirurgias de revascularização miocárdica com e sem circulação extracorpórea: estudo prospectivo randomizado

“…No entanto, essa hemostasia preservada pode resultar em atividade pró-coagulante após cirurgias sem CEC 18 . Este estado pró-coagulante é descrito em cirurgias de grande porte [19][20][21] e, também, pode ser esperado após cirurgias cardíacas como a revascularização miocárdica, acarretando um risco aumentado de tromboses. Além disso, na cirurgia sem CEC, existe maior dificuldade técnica em relação à cirurgia que utiliza a parada cardioplégica do coração, o que pode levar a uma revascularização incompleta com maior frequência.…”