Elevated plasma intestinal fatty acid binding protein and aberrant lipid metabolism predict post-stroke depression

Zhong, Jianqiao; Chen, Jianjun; Cao, Maolin; Fang, Liang; Wang, Zhenyu; Liao, Juan; Chen, Dan; Zhang, Xiaoli; Guo, Jiaxun; Zhao, Libo; Zhou, Chanjuan

doi:10.1016/j.heliyon.2022.e11848

Cited by 10 publications

(9 citation statements)

References 51 publications

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“…Although the direct causal relationship between gut permeability and depression has not yet been fully understood, there is some research exploring the role of iFABP in the development of PSD (6,(24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

Prediction of post-stroke depression with combined blood biomarkers IL-6, TNF-a, and fatty acid binding protein: A prospective study

Wang¹,

Chen²,

Zhu³

et al. 2023

J Med Biochemistry

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Background: To investigate the expression levels of blood biomarkers interleukin-6 (IL-6), tumor necrosis factor (TNF-α), and intestinal fatty acid binding protein (iFABP) in patients with post-stroke depression (PSD), and their correlation with PSD occurrence. Methods: Clinical data of stroke patients admitted to the First People’s Hospital of Wenling from December 2017 to December 2022 were retrospectively analyzed. Patients were classified into two groups based on their Hamilton Depression Rating Scale (HAMD) scores: PSD and non-PSD groups. The blood levels of IL-6, TNF-α, and iFABP were compared between the two groups, and their association with PSD occurrence was analyzed. Results: The PSD group had significantly higher levels of IL-6, TNF-α, and iFABP. The combined detection of these biomarkers demonstrated a greater predictive value for PSD occurrence compared to the individual detection of each biomarker. Conclusion: The study indicates that the levels of IL-6, TNF-α, and iFABP in the blood are significantly increased in patients with PSD. The combined detection of these biomarkers can effectively predict the occurrence of PSD, indicating high clinical value.

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Section: Discussionmentioning

confidence: 99%

Prediction of post-stroke depression with combined blood biomarkers IL-6, TNF-a, and fatty acid binding protein: A prospective study

Wang¹,

Chen²,

Zhu³

et al. 2023

J Med Biochemistry

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Section: Acupuncture Regulates Intestinal Microbiota In Psdmentioning

confidence: 99%

“…This result may be related to the increase of the relative abundance of Lactobacillus, thus affecting lipid metabolism. And according to relevant study, the aberrant lipid metabolism is one of the predictive biological indicators of PSD (Zhong et al, 2022). Wang et al (2019) showed that electroacupuncture could regulate lipid metabolism and improve insulin sensitivity and glucose homeostasis by regulating intestinal flora composition (mainly by reducing Firmicutes/Bacteroides ratio and increasing Prevotella_9 abundance).…”

Section: Effect On Metabolites and Metabolic Pathwaysmentioning

confidence: 99%

“…In addition to the combination of neurological and psychiatric symptoms, it is also common for PSD patients to have abnormal digestive tract function ( Jiang, 2022 ). Researchers have found a significant difference between patients with PSD and those without PSD in terms of gut microbial community and metabolites ( Jiang et al, 2021 ; Zhong et al, 2022 ). Therefore, it is possible that reasonable gut microbiome composition may play a significant role in maintaining healthy metabolism, and it is increasingly being recognized that depression can be treated with direct changes in intestinal microbiota composition (such as prebiotic intake and fecal microbiota transplantation) ( Evrensel and Tarhan, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

et al. 2023

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Stroke-induced depression is a common complication and an important risk factor for disability. Besides psychiatric symptoms, depressed patients may also exhibit a variety of gastrointestinal symptoms, and even take gastrointestinal symptoms as the primary reason for medical treatment. It is well documented that stress may disrupt the balance of the gut microbiome in patients suffering from post-stroke depression (PSD), and that disruption of the gut microbiome is closely related to the severity of the condition in depressed patients. Therefore, maintaining the balance of intestinal microbiota can be the focus of research on the mechanism of acupuncture in the treatment of PSD. Furthermore, stroke can be effectively treated with acupuncture at all stages and it may act as a special microecological regulator by regulating intestinal microbiota as well. In this article, we reviewed the studies on changing intestinal microbiota after acupuncture treatment and examined the existing problems and development prospects of acupuncture, microbiome, and poststroke depression, in order to provide new ideas for future acupuncture research.

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“…LCFAs are an important part of cell membranes and signaling molecules [11]. They also have anti‐inflammatory effects [12], and are related to obesity [13], stroke [14], cardiovascular [15], and cerebrovascular diseases [16]. Unsaturated LCFAs can be used as potential drugs for the treatment of obesity and cancer [17].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of fatty acids in serum with dual derivatization by liquid chromatography‐tandem mass spectrometry

Lin

et al. 2023

J of Separation Science

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Fatty acids have multitudinous biological functions and play a crucial role in many biological processes, but due to poor ionization efficiency and lack of appropriate internal standards, the comprehensive quantification of fatty acids by liquid chromatography‐tandem mass spectrometry is still challenging. In this study, a new, accurate, and reliable method for quantifying 30 fatty acids in serum using dual derivatization was proposed. Indole‐3‐acetic acid hydrazide derivants of fatty acids were used as the internal standard and indole‐3‐carboxylic acid hydrazide derivants of them were used to quantify. The derivatization conditions were systematically optimized and the method validation results showed good linearity with R2 > 0.9942, low detection limit (0.03–0.6 nM), precision (1.6%–9.8% for intra‐day and 4.6%–14.1% for inter‐day), recovery (88.2%–107.2% with relative standard deviation < 10.5%), matrix effect (88.3%–105.2% with the relative standard deviation < 9.9%) and stability (3.4%–13.8% for fatty acids derivants in 24 h at 4°C and 4.2%–13.8% for three freeze‐thaw cycles). Finally, this method was successfully applied to quantify fatty acids in serum samples of Alzheimer's patients. In contrast to the healthy control group, nine fatty acids showed a significant increase in the Alzheimer's disease group.

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Elevated plasma intestinal fatty acid binding protein and aberrant lipid metabolism predict post-stroke depression

Cited by 10 publications

References 51 publications

Prediction of post-stroke depression with combined blood biomarkers IL-6, TNF-a, and fatty acid binding protein: A prospective study

Prediction of post-stroke depression with combined blood biomarkers IL-6, TNF-a, and fatty acid binding protein: A prospective study

Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

Simultaneous quantification of fatty acids in serum with dual derivatization by liquid chromatography‐tandem mass spectrometry

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